Isaac Bogoch - University Health Network. Toronto, ON, CA

Isaac Bogoch Isaac Bogoch

Clinical Researcher, Toronto General Research Institute | University Health Network

Toronto, ON, CA
Dr. Bogoch's clinical and research interests are in Infectious Diseases, Global Health, Tropical Diseases and HIV

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Biography

Dr. Bogoch completed medical school and internal medicine training at the University of Toronto. He then pursued an infectious diseases fellowship through the Harvard Partners program, and an HIV fellowship at the Massachusetts General Hospital. He holds a Masters degree in clinical epidemiology from the Harvard School of Public Health, and a Diploma in Tropical Medicine and Hygiene from the Gorgas Memorial Institute and the Instituto de Medicina Tropical in Lima, Peru.

Dr. Bogoch's clinical and research interests are in Tropical Diseases and HIV. He works with an international and interdisciplinary team that develops and implements innovative diagnostic tools for neglected tropical diseases in resource-constrained settings. He is also a clinician-investigator in the HIV Prevention Unit, with a focus on developing non-occupational Post-Exposure Prophylaxis and Pre-Exposure Prophylaxis delivery models.

Industry Expertise (5)

Health and Wellness Health Care - Facilities Health Care - Services Education/Learning Research

Areas of Expertise (10)

Zika Virus Hiv / Aids Clinical Epidemiology Infectious Diseases Tropical Diseases Ebola Global Health Emerging Infectious Diseases Medical Education Clinical Medicine

Education (7)

University of Calgary: BSc, - 2000

University of Toronto: Doctor of Medicine (MD), Medicine 2005

University of Toronto: Residency Program, Internal Medicine 2009

Toronto General Hospital and Toronto Western Hospital: Chief Medical Resident, Medicine 2009

Harvard University: Infectious Diseases Fellowship, Infectious Diseases 2011

Universidad Peruana Cayetano Heredia: Gorgas Memorial Course in Tropical Medicine, Tropical Medicine

Harvard School of Public Health: Master of Science (SM), Clinical Epidemiology 2013

Media Appearances (14)

Travelling? Here’s what you need to know about the Zika risk

Toronto Star  online

2016-05-15

Dr. Isaac Bogoch, infectious diseases specialist at Toronto General Hospital, discusses some of the common misconceptions he hears about Zika virus from his patients.

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Zika’s frustration: After you travel, you won’t know if you don’t have it

Toronto Star  online

2016-05-15

“If you really want a zero per cent risk of having a complication from Zika virus, the only way to do that is to not go (to a Zika-affected country),” advises Dr. Isaac Bogoch, infectious disease specialist at Toronto General Hospital.

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Zika virus and the Olympics

Daily Mail  online

2016-05-11

Dr. Isaac Bogoch, an infectious diseases specialist at Toronto General Hospital who has studied the anticipated path of the virus, said while it is 'very likely' the Olympics could speed up the spread of Zika around the world, most people wouldn't be affected.

'The spread of Zika to other countries is already happening,' he said. 'Canceling the Olympics is not going to prevent that.'

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First case of Zika Virus transmitted sexually in Canada confirmed

Global News  tv

2016-04-25

A woman from Ontario is the first person in Canada to contract Zika virus from a sexual partner who had recently returned from a Zika virus-infected area. Dr. Isaac Bogoch, infectious disease specialist at Toronto General Hospital, discusses how to prevent transmission.

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Epidemic potential of infections

Vox  online

2016-04-19

How contagious is a disease? Dr. Isaac Bogoch helps to answer that question when it comes to Zika.

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Zika virus and neurologic disease

CTV  tv

2016-04-13

Dr. Isaac Bogoch, infectious disease specialist at UHN, confirmed the research on the causal relationship between Zika and birth defects.

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Zika virus in the USA and Canada

CBC  tv

2016-04-12

Dr. Isaac Bogoch, infectious disease specialist at UHN, confirmed the research on the causal relationship between Zika and birth defects.

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​Macacos em Uganda, surto na Polinésia e Copa no Brasil: como o zika chegou aqui

Vice (Brazil)  online

2016-03-24

Dr. Isaac Bogoch spoke with Vice (Brazil) about the spread of Zika through the Americas.

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HIV Prevention with PrEP in Canada

CBC Metro Morning  radio

2016-03-02

Dr. Isaac Bogoch spoke with Matt Galloway about Truvada, an HIV treatment that Health Canada recently approved for preventative use. Dr. Bogoch is an infectious disease specialist at Toronto General Hospital.

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'I'm still going': Olympian Sarah Walker commits to Rio despite Zika fears

Sinema Blaze  online

2016-02-03

"It is the flawless set-up for proliferation", said Isaac Bogoch, a tropical infectious disease specialist at Toronto General Hospital, who published a scientific paper predicting Zika's rapid spread.

In Brazil, where the virus is believed to have arrived in the hemisphere before spreading via mosquitoes, it has been linked to a brain defect in almost 4 000 newborns. There has also been an increase in reported cases of Guillain-Barre muscle weakness syndrome...

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Zika virus outbreak 'spreading explosively': WHO

CBC News  online

2016-01-28

"If Canadians are interested in going to Central America or South America, Mexico, the Caribbean, and they're not pregnant and they're not considering becoming pregnant in the next little bit, they should just be as concerned as they normally are when they travel to those areas, which is not very concerned at all," said Dr. Isaac Bogoch, a tropical infectious disease expert at Toronto's University Health Network...

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Rapid spread of Zika virus in the Americas raises alarm

Science News  online

2016-01-22

In the United States, that could leave millions of people at risk for infection, Isaac Bogoch and colleagues reported January 14 in the Lancet. Bogoch’s team made a global map of places Zika virus could readily spread. The researchers factored in climate, flight patterns out of Brazil, and mosquito species that can carry Zika virus, Aedes aegypti and Aedes albopictus. (Both species hug the U.S. Gulf Coast, and A. albopictus fans out across the southeast and up along the coast, ranging as far north as Connecticut.)

As many as 60 percent of U.S. residents live in areas threatened by Zika virus (at least during warm seasons), the team found. For southern states, especially, “there’s a potential for ongoing transmission,” says Bogoch, a tropical infectious diseases physician at Toronto General Hospital...

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Zika Warning Spotlights Latin America’s Fight Against Mosquito-Borne Diseases

The New York Times  online

2016-01-17

Dr. Isaac I. Bogoch, a tropical infectious disease specialist at the University of Toronto who is part of a team modeling the potential for Zika to spread, warned that the Olympics could serve as a catalyst for the virus, which some researchers believe may have arrived in Brazil during another sports mega-event, the 2014 World Cup.

“There will be people traveling to Brazil from all over the world,” Dr. Bogoch said in an email.

“The concern is that infected individuals will travel back to their home country and introduce the virus to new regions.”

Dr. Bogoch and other researchers determined that Zika had the potential to rapidly spread to other parts of the world, according to findings published last week in the British medical journal The Lancet...

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Olympics in Brazil could spark spread of Zika virus abroad, Canadian docs warn

Global News  online

2016-01-14

“People might go to Brazil, get the infection and bring it home to their home country and if they’re living in an area conducive for seasonal or year-round transmission, the infection will be present in a new area. We don’t even need to wait for the Olympics to happen, it’s happening now,” warned Dr. Isaac Bogoch, a tropical infectious disease specialist at Toronto General Hospital and the University of Toronto.

“[The Olympics] has the potential to amplify spread. It’s something we have to be aware of and certainly have an understanding of,” he told Global News...

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Articles (12)

Feasibility of HIV Pre-Exposure Prophylaxis
PubMed

2016

As part of routine care in Toronto, Canada

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Zika virus infection
PubMed

2016

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Anticipating the international spread of Zika virus from Brazil
PubMed

2016

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Assessment of the potential for international dissemination of Ebola virus via commercial air travel during the 2014 west African outbreak
PubMed

2015

The WHO declared the 2014 west African Ebola epidemic a public health emergency of international concern in view of its potential for further international spread. Decision makers worldwide are in need of empirical data to inform and implement emergency response measures. Our aim was to assess the potential for Ebola virus to spread across international borders via commercial air travel and assess the relative efficiency of exit versus entry screening of travellers at commercial airports.

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Comparison of community-wide, integrated mass drug administration strategies for schistosomiasis and soil-transmitted helminthiasis: a cost-effectiveness modelling study
PubMed

2015

More than 1·5 billion people are affected by schistosomiasis or soil-transmitted helminthiasis. WHO's recommendations for mass drug administration (MDA) against these parasitic infections emphasise treatment of school-aged children, using separate treatment guidelines for these two helminthiases groups. We aimed to evaluate the cost-effectiveness of expanding integrated MDA to the entire community in four settings in Côte d'Ivoire.

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Patient attrition between the emergency department and clinic among individuals presenting for HIV nonoccupational postexposure prophylaxis
PubMed

2014

Nonoccupational postexposure prophylaxis (nPEP) is recommended after a sexual or parenteral exposure to human immunodeficiency virus (HIV). Patients frequently seek care in an emergency department (ED) after an exposure and are usually referred to an HIV clinic for further management. There have been few data on determinants of attrition after presentation to EDs for nPEP.

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Mapping the zoonotic niche of Ebola virus disease in Africa
Elife

2014

Ebola virus disease (EVD) is a complex zoonosis that is highly virulent in humans. The largest recorded outbreak of EVD is ongoing in West Africa, outside of its previously reported and predicted niche. We assembled location data on all recorded zoonotic transmission to humans and Ebola virus infection in bats and primates (1976–2014). Using species distribution models, these occurrence data were paired with environmental covariates to predict a zoonotic transmission niche covering 22 countries across Central ...

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Mobile phone microscopy for the diagnosis of soil-transmitted helminth infections: a proof-of-concept study
PubMed

2013

We created a mobile phone microscope and assessed its accuracy for the diagnosis of soil-transmitted helminths compared with conventional microscopy. Mobile phone microscopy has a sensitivity of 69.4% for detecting any helminth egg and sensitivities of 81.0%, 54.4%, and 14.3% for the diagnosis of Ascaris lumbricoides, Trichuris trichiura and hookworm respectively.

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Delirium in the postoperative cardiac patient: a review
Journal of Cardiac Surgery

2005

Background and aim of review: Cardiac surgery is increasingly common and relatively safe, but there are frequent reports of neuropsychiatric sequelae occurring in the postoperative period. One of the most common neuropsychiatric presentations of cardiac surgery is delirium, also called postcardiotomy delirium (PCD). Despite the vast numbers of cardiac surgeries performed today, there is a paucity of data on risk factors and management options of PCD available to the clinician. This review aims to summarize ...

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Perceptions about hearing protection and noise-induced hearing loss of attendees of rock concerts
Canadian Journal of Public Health

2005

This study examines perceptions of rock concert attendees about risk of noise-induced hearing loss (NIHL) and use of hearing protection at a busy Toronto rock concert venue. Methods: Two hundred and four questionnaires were completed and returned (75% response rate) by attendees at four rock concerts. Results: The respondents had an average age of 20.6 years and 55.4% were male. Thirty-four point three percent (34.3%) thought that it was somewhat likely and 39.8% thought it was very likely that noise levels at music ...

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Efficacy and side effects of praziquantel against Schistosoma mansoni in a community of western Côte d'Ivoire
Transactions of the Royal Society of Tropical Medicine and Hygiene

2004

Praziquantel is efficacious against the adult stages of all human schistosome parasites, and has become the drug of choice for morbidity control of schistosomiasis. There is concern that resistance to praziquantel might develop or already exists, and could be further facilitated through new control initiatives relying on large-scale administration of praziquantel. Therefore, monitoring praziquantel efficacy in different epidemiological settings is required. We assessed the efficacy and side effects of praziquantel against ...

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Enhanced epileptogenesis in S100B knockout mice
Molecular Brain Research

2002

S100B is a small calcium-and zinc-binding protein expressed by astrocytes in the central nervous system. Here, we examined the role of S100B in epileptogenesis using an amygdala kindling paradigm comparing S100B knockout mice with their wild-type counterparts. Astrocyte activation following kindling, assessed by glial fibrillary acidic protein expression in the hippocampus and amygdala, was similar in wild-type and knockout mice. In addition, wild-type and knockout mice did not have substantially different afterdischarge ...

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