Michael P. Shakarjian, Ph.D.
Assistant Professor | New York Medical College
Valhalla, NY, UNITED STATES
Dr. Shakarjian is an assistant professor and program director of environmental health science in the School of Health Sciences and Practice.
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Biography
Michael P. Shakarjian, Ph.D., is assistant professor of environmental health science and program director of M.P.H. environmental health science studies in the School of Health Sciences and Practice. Prior to his academic career, Dr. Shakarjian spent ten years in the pharmaceutical and small biotechnology industries where he was involved in several areas of small molecule and protein-based therapeutics R&D, including target identification and validation, assay development, candidate screening, and GLP/GCP bioanalytical studies. He also holds an adjunct appointment at the Rutgers/Robert Wood Johnson Medical School Department of Medicine where he maintains a collaborative relationship with that institution’s CounterACT Center of Excellence.
Industry Expertise (3)
Biotechnology
Pharmaceuticals
Education/Learning
Areas of Expertise (6)
Countermeasures Against Dermatological and Neurological Poisons
Effects of a Seizure-Inducing Rodenticide (TMDT)
Countermeasures Against Chemical Threats (CounterACT)
Bioterrorism
Therapeutic Medical Countermeasures
Diagnostic Technologies Against Chemical Threat Agents
Education (3)
Virginia Commonwealth University: Ph.D., Pharmacology & Toxicology 1989
SUNY at Buffalo: M.S., Pharmacology & Therapeutics 1980
SUNY at Buffalo: B.A., Biochemical Pharmacology 1977
Affiliations (3)
- Lawrence Brook Watershed Partnership : President
- Association for Women in Science
- Environmental Commission Milltown NJ : Chair
Articles (selected) (4)
Combined Treatment with Diazepam and Mk-801 Provide Enhanced Protection from Tetramethylenedisulfotetramine-Induced Seizures and Lethality
FASEB Journal
2014 ABSTRACT: We sought to characterize the TMDT syndrome in C57BL/6 mice and explore the best modalities for treatment.
Modulation of keratinocyte expression of antioxidants by 4-hydroxynonenal, a lipid peroxidation end product
Toxicology and Applied Pharmacology
2014 ABSTRACT: In these studies, we characterized 4-HNE-induced changes in antioxidant expression in mouse keratinocytes. Treatment of primary mouse keratinocytes and PAM 212 keratinocytes with 4-HNE increased mRNA expression for heme oxygenase-1 (HO-1), catalase, NADPH:quinone oxidoreductase (NQO1) and glutathione S-transferase (GST) A1-2, GSTA3 and GSTA4.
Acceleration of cutaneous wound healing by brassinosteroids
Wound Repair and Regeneration
2013 ABSTRACT: Brassinosteroids are plant growth hormones involved in cell growth, division, and differentiation. Their effects in animals are largely unknown, although recent studies showed that the anabolic properties of brassinosteroids are possibly mediated through the phosphoinositide 3-kinase/protein kinase B signaling pathway. Here, we examined biological activity of homobrassinolide (HB) and its synthetic analogues in in vitro proliferation and migration assays in murine fibroblast and primary keratinocyte cell culture.
Mechanisms of oxidant generation by catalase
Annals of the New York Academy of Sciences
2010 ABSTRACT: In this study, we report that several bacterial catalases (hydroperoxidases, HP), including Escherichia coli HP-I and HP-II also generate reactive oxidants in response to ultraviolet B light (UVB). HP-I and HP-II are identical except for the presence of NADPH.
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