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Kelly Banas, Ph.D., To Present Her Latest Discovery at CRISPR Medicine’s First International Conference

Global audience in Copenhagen, Denmark, will learn of Gene Editing Institute research targeting the NRF2 gene in cancer cells Kelly Banas, Ph.D., principal investigator at ChristianaCare’s Gene Editing Institute, will present her latest research discovery related to targeting the NRF2 gene in cancer cells at the first CRISPR Medicine Conference held in Copenhagen, Denmark, April 22 to 25. The Gene Editing Institute’s research has focused on the NRF2 gene and the strong immune response it causes within cancer cells, allowing them to grow resistant to chemotherapy and leading cancer treatments to fail. By disrupting the NRF2 gene in cancer cells while allowing healthy cells to continue producing it, chemotherapy treatment becomes more effective. Gene Editing Institute principal investigators Kelly Banas, Ph.D., and Natalia Rivera-Torres, Ph.D., in the lab. Banas’ latest research delves into the mechanism of DNA repair following the removal of NRF2, ensuring that surrounding DNA in healthy cells is not affected and that the repair does not produce an unexpected outcome. “I’m extremely honored to be invited to this conference to highlight the work that all of our researchers at the Gene Editing Institute have put into this study,” Banas said. “The work we have done to characterize the impact of CRISPR on the NRF2 gene has changed how we approach new cancer targets. “This has influenced how we design experiments and analyze our data,” she said, “so it’s got a big impact on not just our work, but the work of anyone we collaborate with in the future. This community is full of phenomenal voices, and we’re committed to sharing our work in contexts like this to continue building a foundation of CRISPR research that will uplift treatment for some of the deadliest and most resilient cancers and diseases.” Read about Banas’ earlier research here.

NASA selects University of Delaware’s CubeSat spacecraft for upcoming mission

It’s safe to say that not many students expect to lead a NASA-supported mission during their undergraduate studies. But at least a dozen from the University of Delaware will have done that by the time they collect their diplomas in the next few years. All are part of a team creating Delaware’s first orbital spacecraft, which was selected by NASA for launch in 2026 as part of its CubeSat Launch Initiative. The NASA program, which started in 2011, aims to give students an opportunity to be part of real missions and gain extraordinary experience in what it takes to do space research. CubeSats are small, modular, inexpensive satellites that carry experiments for science investigations and/or technology demonstrations. About 160 CubeSats have been launched in the NASA program over the years, many deployed from the International Space Station (ISS). Delaware’s mission — the Delaware Atmospheric Plasma Probe Experiment (DAPPEr) — will launch its CubeSat spacecraft from the ISS and orbit independently through Earth’s upper atmosphere. The CubeSat will be about the size of a loaf of bread, according to the team’s faculty mentor, Bennett Maruca, associate professor of physics and astronomy. It will gather data about the density and temperature of electrons in Earth’s upper atmosphere, recording changes observed at different latitudes and times of day. This data will inform future research on how the sun affects conditions there. Understanding the sun’s interaction with the Earth’s atmosphere is critical to development of satellite communications networks, global positioning systems (GPS) and national security. But the real objective is educational, Maruca said. The students are the “deliverables.” They’ll emerge from this work with an insider’s view of what it’s like to develop and work on a NASA mission. To arrange an interview with Maruca, contact UD's media relations team at mediarelations@udel.edu.

Covering the tensions in the Middle East - our experts are here to help with your stories

Photo credit: Timon Studler With escalating tensions in the Middle East, the situation seems to be changing on a daily basis. Robert Rabil, Ph.D., is an expert in political Islam, terrorism, U.S. foreign policy, and U.S.-Arab relations at Florida Atlantic University, and can speak about the current climate in the region, as well as offer expertise on its deep history. Simply click on Rabil’s icon now to arrange a time to speak to him.

Covering 4/20? Our experts can help you see through the smoke | Media Advisory

As 4/20 approaches, the spotlight once again turns to the evolving landscape of marijuana legalization and its broader societal impacts. This annual observance not only marks a cultural moment for cannabis enthusiasts but also prompts discussions about the legal, economic, and public health implications of marijuana use in the United States. Here are key story angles for journalists to explore: Legalization efforts and state-by-state updates: Tracking the progress of marijuana legalization initiatives across the country and analyzing the legal frameworks governing recreational and medicinal cannabis use. Economic opportunities and challenges: Investigating the economic impact of the cannabis industry, including job creation, tax revenue generation, and business opportunities, as well as regulatory hurdles and market fluctuations. Social justice and equity in cannabis legalization: Examining efforts to address historical inequities in drug enforcement and incarceration through policies such as expungement, social equity programs, and community reinvestment. Public health and safety considerations: Assessing the health effects of marijuana use, the regulation of cannabis products, and efforts to mitigate potential risks such as underage consumption and impaired driving. Cannabis culture and mainstream acceptance: Exploring the evolving perceptions of marijuana in society, including trends in consumption habits, cannabis tourism, and its portrayal in media and popular culture. International perspectives on marijuana policy: Comparing approaches to marijuana legalization and regulation in other countries and evaluating lessons learned for U.S. policymakers and stakeholders. Connect with an Expert about Marijuana in America: For journalists with questions or looking to cover the streaming wars? here is a select list of experts. To search our full list of experts visit www.expertfile.com Robert Mikos Professor of Law · Vanderbilt University Michael Ostrowsky Professor of Sociology · Southern Utah University Jennifer Whitehill Associate Professor of Health Policy and Management · University of Massachusetts Amherst Daniele Piomelli Distinguished Professor · UC Irvine Almut Winterstein Distinguished Professor · University of Florida Photo Credit: Dylan Mullins

New research shines a light on how expert mapmakers at Ordnance Survey see the world differently

OS Remote Sensing Services survey team updating OS MasterMap using the latest aerial imagery (Image credit: OS) Aston University psychologists worked with Ordnance Survey to assess how surveyors use 3D aerial images when making maps Humans naturally assume light comes from above, but experienced surveyors can interpret visual cues to assess topography regardless of the light direction It is the first time it has been shown that experience can radically alter natural human assumptions about lighting and could improve surveyor training. Researchers at Aston University have found differences between experienced Ordnance Survey (OS) mapmakers and novices in the way that they interpret aerial images for mapmaking, which could lead to improved training processes for new recruits. OS is well known for its travel and walking maps, but is also responsible for maintaining Great Britain’s national geographic database. Every time a building is demolished or developed, or a new road and path built, the map must be updated. Aerial photographs are taken of the area that has changed, either from a plane or using drones, and expert mapmakers, known as remote sensing surveyors, will examine the images to identify change and accurately redraw the map of the area. Image pairs are presented stereoscopically, one to each eye, allowing the remote sensing surveyors to see in 3D and correctly assess the topography, such as ditches, hills and hedges. Led by Professor Andrew Schofield, a team from Aston University’s College of Health and Life Sciences, together with Dr Isabel Sargent, previously at OS, carried out a study to understand how remote sensing surveyors interpret the shadows and highlights in images. The researchers asked six trained remote sensing surveyors and six novices to assess 10,000 stereoscopic aerial images of hedges and ditches, which had been heavily masked with image distortions. The stereoscopic images the aerial surveyors use for mapmaking are usually taken on sunny days. The human brain is naturally wired to interpret light as coming from above. However, the light does not come from above in the OS aerial images, it depends on the position of the sun. In the UK, north of the equator, light comes slightly from the south, thus appearing to come from below in images viewed by the surveyors. The researchers wanted to see how manipulating the direction of the light would affect the surveyors. Professor Schofield and the team swapped the image pairs between the eyes in half of the trials, so that hedges might look like ditches, and ditches look like hedges. The images were also flipped vertically on half the trials, changing the direction of the light source. Expert surveyors were found to rely on the stereoscopic cues – the difference in images seen by the two eyes – when performing the task. Novices were more likely to rely on lighting cues – highlights and shadows – to judge the shape and relief of an object, and assumed, as is natural, that the lighting came from above. With the manipulated images, this meant that novices frequently made mistakes. Experts were more accurate, even when the images had been turned upside down, and some had learnt to assume that the light source came from the south, or below. This is the first time anyone has shown that the natural assumption that light comes from above, which is common amongst many animal species, can be changed through long term experience. The researchers say that it could be used to develop new visual training techniques for remote sensing surveyors. For example, intensive exposure to repeated, difficult images can improve performance via a process called perceptual learning. Professor Schofield said: “This is a very exciting result. Others have shown that the light-from-above assumption can be altered by a few degrees, but no one has ever found complete reversals following long term experience. Dr Sargent said: “This result will help Ordnance Survey to understand the expertise of their staff and improve surveyor training and procedures.” Remote sensing surveyor Andy Ormerod, who worked on the study, said: “This research proves that experienced remote sensing surveyors can see the world differently. Whereas non-surveyors are used to seeing the world from one perspective, our brains have learned to view the world as seen from aerial imagery.” Journal of Vision DOI:10.1167/jov.24.4.11

Who’s winning the streaming wars?| Media Advisory

Netflix has it's Q1 results out today and all eyes are on the streaming industry. The battle for dominance in the streaming industry continues to intensify, shaping the way audiences consume entertainment and influencing the future of media consumption. As major players vie for subscribers and content rights, the outcome of the streaming wars has significant implications for consumers, content creators, and the broader entertainment landscape. Here are key story angles for journalists to explore: Market analysis of streaming platforms: Examining the strategies and market performance of leading streaming services in terms of subscriber growth, revenue, and content offerings. Impact on traditional media and broadcasting: Investigating how the rise of streaming platforms is reshaping traditional television and movie distribution models, as well as advertising trends. Content wars and original programming: Delving into the competition among streaming services to produce exclusive and original content, including trends in genres, diversity, and production budgets. User experience and interface innovation: Exploring advancements in streaming technology, user interface design, and personalization features aimed at enhancing the viewer experience. Global expansion and regional competition: Analyzing the expansion efforts of streaming giants into international markets and the challenges they face in competing with local and regional players. Regulatory and antitrust implications: Considering the regulatory scrutiny and antitrust concerns surrounding the dominance of certain streaming platforms and their impact on competition and consumer choice. Connect with an Expert about Streaming: For journalists with questions or looking to cover the streaming wars? here is a select list of experts. To search our full list of experts visit www.expertfile.com Rahul Telang Trustees Professor and Program Chair · Carnegie Mellon University Donghee Yvette Wohn Associate Professor · New Jersey Institute of Technology Michael D. Smith Professor · Carnegie Mellon University Karen Shackleford, Ph.D. Doctoral Faculty - Media Psychology · Fielding Graduate University Stephen J. Andriole, PhD Thomas G. Labrecque Professor of Business Technology | Villanova School of Business · Villanova University Photo Credit: Venti Views

Demystifying Relapse: 2-part series on substance use disorder recurrence and treatment

CARF International Senior Managing Director of Behavioral Health Michael Johnson is a contributor of this terrific two-part series on substance use relapse from the National Council for Mental Wellbeing. NATCON and partnering contributors from CARF International, National Association of Addiction Treatment Providers (NAATP), and the Recovery Research Institute are excited to release the Demystifying Relapse series, which includes two issue briefs that explore the complex dynamics of substance use disorder recurrence and the difficulty of reengaging individuals in the recovery process. “I’m grateful to the National Council for Mental Wellbeing for the opportunity to work with them on these two important documents. The U.S. is facing unprecedented challenges in treating persons with substance use disorders, with access to care continuing to be difficult for many. The field, the payers, and the public at large needs to take time to recalibrate how treatment and return to use are viewed in order to have realistic expectations for care, to destigmatize what it means for a person to return to use, and to ensure there is appropriate types of care available to those who need to re-enter the treatment systems,” said Senior Managing Director of Behavioral Health Michael Johnson. “Only when we recognize that persons who return to use need to have care that is individualized to assist them to stabilize, not start over, can we better ensure that treatment systems are more accessible based on the needs of persons served. The treatment for any chronic illness can be difficult as the path to wellness is often not linear. I hope these two papers can start a dialogue on how to reframe the systems to better meet the needs of those who continue with the recurrence of symptoms.” Michael Johnson is the CARF International Senior Managing Director of Behavioral Health. If you are looking to know more or connect with Michael, view his profile below to arrange an interview today.

MEDIA RELEASE: CAA Manitoba Survey Reveals Alarming Data on Cannabis-Impaired Driving in Manitoba

CAA Manitoba (CAA MB) is encouraging Manitoba drivers to remain vigilant this month by driving responsibly – and sober. In a recent survey conducted by CAA Manitoba, alarming data highlights concerns related to cannabis-impaired driving, particularly involving edibles. Key findings from the 2023 survey found that since legalization, a third of cannabis-impaired drivers (27 per cent) in Manitoba have driven a vehicle after consuming an edible form of cannabis. “The data shows us that there is a significant number of impaired drivers under the influence of edible cannabis, which poses a great risk to road safety,” says Ewald Friesen, community and government relations manager at CAA Manitoba. “Edibles pose a greater risk for impairment and road safety since they can often take up to two hours for the effects to kick in.” According to the survey, 61 per cent of cannabis-impaired drivers in Manitoba wait less than three hours before getting behind the wheel. Due to the prolonged absorption of edible cannabis, the potential for drivers to get behind the wheel before they even realize they are beginning to feel the effects poses a serious risk to road safety. The data shows that 89 per cent of Manitoba drivers agree that driving under the influence of cannabis is a serious risk to road safety. However, 67 per cent of cannabis-impaired drivers feel confident in their ability to drive. “While some believe that cannabis doesn’t impair their driving ability, it has been proven to affect coordination, reaction time, decision-making and the ability to pay attention. We would like to see more public education and awareness on the risks of cannabis-impaired driving,” says Friesen. More than half of Manitoba drivers (64 per cent) believe that cannabis-impaired driving is the most important public education topic related to cannabis – more than education on health risks (63 per cent) and health risks for youth under 25 (59 per cent). Despite the concern for road safety and driving impairment, 21 per cent of Manitoba drivers are not aware of the penalties that could be faced for any type of impaired driving. According to Manitoba Public Insurance, this can include an immediate 24-hour licence suspension with a maximum of 60 days upon further testing, a $400 vehicle impoundment of three days, a mandatory Impaired Driver Assessment at the driver’s expense and potential charges under the Criminal Code of Canada. CAA is encouraging motorists to get informed, know the rules, and make the right choices – don’t get behind the wheel when impaired. Instead, make alternate arrangements, such as utilizing rideshare services, to ensure a safe journey home. Dig Insights conducted an online survey on behalf of CAA Manitoba between June 22 to July 5, 2023, of 500 Manitoba drivers aged 19-75 who had access to a vehicle. Based on the sample size and the confidence level (95 per cent), the margin of error for this study was +/- 3 per cent.