Deepa Dabir

Professor of Biology

  • Los Angeles CA UNITED STATES

Seaver College of Science and Engineering

Contact

Media

Biography

Contact
Phone: 310.338.4200
Email: Deepa.Dabir@lmu.edu
Office: Life Sciences Building 283

Deepa Dabir is a Professor of Biology at Loyola Marymount University.

Education

University of Pennsylvania

Ph.D.

Biology

2006

University of Pune, India

M.S.

Biotechnology

2000

St. Xavier's College, Mumbai

B.Sc.

Life Sciences/Biochemistry

1998

Areas of Expertise

Yeast Genetics
Neuroscience
Cell Biology
Molecular Biology
Neurodegenerative Disease
Mitochondria
Disease
Disease Mechanisms

Industry Expertise

Research
Education/Learning

Articles

Mia40 serves as an electron sink in the Mia40-Erv1 import pathway

Journal of Biological Chemistry

2015-06-01

A redox-regulated import pathway consisting of Mia40 and Erv1 mediates the import of cysteine-rich proteins into the mitochondrial intermembrane space. Mia40 is the oxidoreductase that inserts two disulfide bonds into the substrate simultaneously. However, Mia40 has one redox-active cysteine pair, resulting in ambiguity about how Mia40 accepts numerous electrons during substrate oxidation.

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A Small Molecule Inhibitor of Redox-Regulated Protein Translocation into Mitochondria

Developmental Cell

2013-04-01

The mitochondrial disulfide relay system of Mia40 and Erv1/ALR facilitates import of the small translocase of the inner membrane (Tim) proteins and cysteine-rich proteins. A chemical screen identified small molecules that inhibit Erv1 oxidase activity, thereby facilitating dissection of the disulfide relay system in yeast and vertebrate mitochondria.

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Meiosis I Arrest Abnormalities Lead to Severe Oligozoospermia in Meiosis 1 Arresting Protein (M1ap)-Deficient Mice

Biology of Reproduction

2012-12-01

Meiosis 1 arresting protein (M1ap) is a novel vertebrate gene expressed exclusively in germ cells of the embryonic ovary and the adult testis. In male mice, M1ap expression, which is present from spermatogonia to secondary spermatocytes, is evolutionarily conserved and has a specific spatial and temporal pattern suggestive of a role during germ cell development. To test its function mice deficient in M1ap were created.

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