Zvi Schwartz, D.M.D., Ph.D.

Professor, Department of Biomedical Engineering

  • Engineering West Hall, Room 397, Richmond VA UNITED STATES

Doctor of dental medicine and periodontal expert; skilled program developer



Industry Expertise

Program Development
Public Policy

Areas of Expertise

Bone Cartilage and mineralization and their relation to Vitamin D sex hormones and local factors.
Implant and bone substitute mechanism of action and clinical use
Steroid hormone
Periodontal diseases etiology and treatment
The Effect of Vitamin D on Cartilage Cells in Vitro
The Effect of Sex Hormones on Endochondral Bone Formation


Fellow, American Institute for Medical and Biological Engineering


First Prichard Competition, Southwestern Society for Periodontology Annual Meeting in Dallas


Excellence in Teaching Hebrew University


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The Hebrew University, Hadassah Faculty of Dental Medicine


Experimental Pathology


The Hebrew University, Hadassah Faculty of Dental Medicine

Graduate training



The Hebrew University, Hadassah Faculty of Dental Medicine





  • Professor Emeritus : Hebrew University
  • Professor of Periodontics : UTHCSA
  • Organization for the Study of Sex Differences
  • International Association of Dental Research
  • The Israel Dental Association
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Selected Articles

Substrate Stiffness Controls Osteoblastic and Chondrocytic Differentiation of Mesenchymal Stem Cells without Exogenous Stimuli



Stem cell fate has been linked to the mechanical properties of their underlying substrate, affecting mechanoreceptors and ultimately leading to downstream biological response. Studies have used polymers to mimic the stiffness of extracellular matrix as well as of individual tissues and shown mesenchymal stem cells (MSCs) could be directed along specific lineages. In this study, we examined the role of stiffness in MSC differentiation to two closely related cell phenotypes: osteoblast and chondrocyte.

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Characterization of osteoarthritic human knees indicates potential sex differences

Biology of Sex Differences


The prevalence of osteoarthritis is higher in women than in men in every age group, and overall prevalence increases with advancing age. Sex-specific differences in the properties of osteoarthritic joint tissues may permit the development of sex-specific therapies. Sex hormones regulate cartilage and bone development and homeostasis in a sex-dependent manner. Recent in vitro studies show that the vitamin D3 metabolite 1α,25-dihydroxyvitamin D3 [1α,25(OH)2D3] also has sex-specific effects on musculoskeletal cells, suggesting that vitamin D3 metabolites may play a role in osteoarthritis-related sex-specific differences. The purpose of this study was to determine if sex-specific differences exist in synovial fluid and knee tissues isolated from male and female patients with severe knee osteoarthritis.

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Effects of low‐frequency ultrasound treatment of titanium surface roughness on osteoblast phenotype and maturation

Clinical Oral Implants Research


Low-frequency ultrasound is widely used in the treatment of chronically infected wounds. To investigate its feasibility as a method for in situ restoration of metal implant surfaces in cases of peri-implantitis, we evaluated how low-frequency ultrasound affected surface properties of and response of human osteoblast-like MG63 cells to titanium (Ti). Material and methods: Three Ti surfaces [hydrophobic/smooth (pretreatment, PT); hydrophobic/rough (sandblasted/acid-etched, SLA); and hydrophilic/rough (SLA processed and stored hydrophilicity, mSLA)] were subjected to 25 kHz ultrasound for 10 min/cm(2) . Substrate roughness, chemical composition, and wettability were analyzed before and after ultrasound application. Osteoblastic maturation of cells on sonicated disks was compared to cells on untreated disks.

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