Dr. John Granton
Respirologist | University Health Network
Toronto, ON, CANADA
Dr. Granton is an eminent respirologist with Toronto's University Health Network
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Biography
After graduating from the University of Western Ontario in pharmacology / toxicology, Dr. John Granton completed medical school at McMaster University. He pursued training in internal medicine, respiratory medicine, and critical care at the University of Toronto and completed research training at the University of British Columbia. He is currently an intensivist at the Toronto General Hospital and Associate Professor of Medicine at the University of Toronto. He is the head of respirology at University Health Network, Mount Sinai Hospital and Women’s College Hospital. His research interests are in pulmonary hypertension and critical illness.
Industry Expertise (4)
Research
Health Care - Services
Health Care - Providers
Health and Wellness
Areas of Expertise (7)
Treatment and Prognostic Studies in Pulmonary Hypertension
Neurohormonal Activation in Pulmonary Hypertension
Eisenmenger Syndrome
Exercise Physiology
Heart-Lung Interactions
Sepsis
Acute Lung Injury
Affiliations (7)
- Chair, Clinical Research Audit Committee UHN
- Chair, Pharmacy and Therapeutics Committee UHN
- Division Head, Respirology, UHN, MSH and WCH
- Past Chair of the Canadian Critical Care Society
- Past Chair of the Ontario Thoracic Society
- Professor, University of Toronto
- Chair, Ontario Lung Association
Media Appearances (2)
Pulmonary hypertension a rare disease that causes high blood pressure in the lungs
Pulmonary Hypertension Association of Canada Toronto Chapter online
2012-01-02
“I don’t look sick, but you don’t know what goes on inside my body,” says Carol Doyle. The 42 year-old Georgetown, Ont., mom knew something was not right when, in 2004, just after her son was born, she retained fluid and occasionally blacked out. “I could just pass out,” she says, recalling how doctors found nothing significant – even after another pregnancy during which she had similar symptoms, including serious fluid retention. “After my daughter was born, they again said it would go away. But it didn’t and I could barely walk. If you pressed your finger into my leg it was like a kind of memory foam,” Doyle explains. Fortunately, her family doctor, realizing her symptoms had nothing to do with pregnancy, sent her to an internist. Results of further tests confirmed pulmonary hypertension or PH, a condition rare enough to be termed an “orphan” disease. “Like many uncommon diseases, we struggle with awareness,” says Dr. John Granton, director of the Pulmonary Hypertension Program at the University Health Network’s Toronto General Hospital. “We find that nobody has heard of PH and the people who have it often look very well.”
Hassan Rasouli to move out of Sunnybrook after long end-of-life court battle
The Star online
2013-12-31
A patient at the centre of a controversial Supreme Court decision on end-of-life care is on a waiting list to be transferred out of hospital to another health-care facility, where he will be expected to pay part of the tab. The move is both good and bad news for Hassan Rasouli and his family. When he is transferred out of Sunnybrook Health Sciences Centre, he will no longer be under the care of doctors who had wanted to remove him from life support. But when he becomes a resident of Toronto’s West Park Healthcare Centre, he will have to pay a monthly basic accommodation fee of $1,707, an amount his family says they cannot afford.
Articles (5)
Utility of the physical examination in detecting pulmonary hypertension. A mixed methods study
PubMed.gov
2014-10-01
Patients with pulmonary hypertension (PH) often present with a variety of physical findings reflecting a volume or pressure overloaded right ventricle (RV). However, there is no consensus regarding the diagnostic utility of the physical examination in PH.
De novo synthesize of bile acids in pulmonary arterial hypertension lung
PubMed.gov
2014-01-01
Although multiple, complex molecular studies have been done for understanding the development and progression of pulmonary hypertension (PAH), little is known about the metabolic heterogeneity of PAH. Using a combination of high-throughput liquid-and-gas-chromatography-based mass spectrometry, we found bile acid metabolites, which are normally product derivatives of the liver and gallbladder, were highly increased in the PAH lung. Microarray showed that the gene encoding cytochrome P450 7B1 (CYP7B1), an isozyme for bile acid synthesis, was highly expressed in the PAH lung compared with the control. CYP7B1 protein was found to be primarily localized on pulmonary vascular endothelial cells suggesting de novo bile acid synthesis may be involved in the development of PAH. Here, by profiling the metabolomic heterogeneity of the PAH lung, we reveal a newly discovered pathogenesis mechanism of PAH.
Recovery of respiratory gas exchange after exercise in adults with congenital heart disease
PubMed.gov
2014-09-01
Delayed gas exchange kinetics in the early recovery period after exercise testing has been reported in children and adults with congenital heart disease (ACHD). Our objective was to compare early and late phase recovery kinetics in three groups of ACHD-patients.
Oxygenation response to positive end-expiratory pressure predicts mortality in acute respiratory distress syndrome. A secondary analysis of the LOVS and ExPress trials
PubMed.gov
2014-07-01
Previous trials of higher positive end-expiratory pressure (PEEP) for acute respiratory distress syndrome (ARDS) failed to demonstrate mortality benefit, possibly because of differences in lung recruitability among patients with ARDS.
Critical care trainees' career goals and needs: A Canadian survey
PubMed.gov
2014-03-01
For training programs to meet the needs of trainees, an understanding of their career goals and expectations is required.