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Michael Thomashow - Michigan State University. East Lansing, MI, US

Michael Thomashow Michael Thomashow

University Distinguished Professor | Michigan State University

East Lansing, MI, UNITED STATES

Is an expert on the regulation of abiotic & biotic stress tolerance pathways in plants with an emphasis on plant freezing tolerance

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Biography

Dr. Thomashow received his A.B and Ph.D. degrees from UCLA majoring in microbiology and then conducted postdoctoral research as a Damon Runyon-Walter Cancer Fund Research Fellow at the University of Washington. His first faculty position was at Washington State University followed by his moving to MSU where he has been since 1986.

Prior to Thomashow moving to MSU, he worked on the plant pathogen Agrobacterium tumefacians, which causes crown gall disease. As a postdoctoral fellow and assistant professor, he and his colleagues discovered that crown gall disease involves the transfer of DNA from the bacterium to the plant where it becomes integrated into the plant nuclear genome and is expressed resulting in the biosynthesis of nutrients that the bacteria use for growth. These studies demonstrated that Agrobacterium is a natural genetic engineer of plants. Subsequent work by others converted Agrobacterium into the primary system to produce GMO crops.

Upon arrival at MSU, Thomashow initiated a new line of investigation: determining the molecular basis for plant freezing tolerance. His research led to the discovery of the first freezing tolerance pathway in plants—the CBF Pathway—and the identification of multiple transcription factors that regulate expression of the pathway in response to low temperature, the circadian clock and photoperiod. Current research focuses on determining how plants sense low temperature and activate the CBF and other regulatory pathways that promote cold tolerance and increase immunity against bacterial pathogens. Thomashow’s goal is to further basic understanding of abiotic and biotic stress response pathways providing information that can be used to improve plant resilience.

Dr. Thomashow has served as President of the American Society for Plant Biologists, Director of the MSU-DOE Plant Research Laboratory, and Founding Director of the Plant Resilience Institute.

Industry Expertise (3)

Education/Learning Writing and Editing Research

Areas of Expertise (5)

Biochemistry Soil and Microbial Sciences Plant Biology Molecular Biology Plants

Education (1)

University of California - Los Angeles: Ph.D.

Affiliations (3)

  • American Academy of Microbiology : Fellow
  • American Society of Plant Biologists : Fellow
  • American Association for the Advancement of Science : Fellow

News (5)

HOW PLANTS ‘MUSCLE UP’ AGAINST BACTERIA IN THE COLD

MSU Today  online

2018-01-26

In the cold, plants generally build up high levels of salicylic acid, or SA, a compound that protects them against bacteria.

“At warm temperatures CAMTA proteins, specifically the N-terminus (the start of the proteins), block the system that produces SA,” said Yong Sig Kim, a post-doctoral student in the lab of University Distinguished Professor and MSU Foundation Professor Michael Thomashow...

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Circadian rhythms spark plants' ability to survive freezing weather, says AgBioResearch scientist

MSU Today  online

2011-04-14

All living things – humans, animals, plants, microbes – are influenced by circadian rhythms, which are physical, mental and behavioral changes that follow a 24-hour cycle. In the current issue of the Proceedings of the National Academy of Sciences, AgBioResearch scientist Michael Thomashow, along with Michigan State University (MSU) colleagues Malia Dong and Eva Farré, explains that the circadian clock provides key input required for plants to attain maximum freezing tolerance.

“The integration of cold-signaling pathways with the circadian clock may have been an important evolutionary event that has contributed to plant adaptation to cold environments,” Thomashow said.

Thomashow, who is also an MSU university distinguished professor of molecular genetics and an elected member of the National Academy of Sciences for his contributions to the field of plant biology, has focused his research on the identification of stress response pathways involved in freezing and drought tolerance. Stresses, including extreme temperatures and water deficit, are major factors that limit the geographical locations where food and potential bioenergy crops can be grown.

His research led to the identification of the C-repeat binding factor, or CBF response pathway, a stress pathway that can be found in many plants and plays a major role in freezing and drought tolerance. Reducing abiotic stresses, such as extremes in temperature and drought, can help expand where crops can be grown and increase annual yields, Thomashow said.

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Benning named director of MSU/DOE Plant Research Laboratory

MSU Today  online

2015-07-23

He succeeds Michael Thomashow, University Distinguished Professor of plant, soil and microbial sciences, and microbiology and molecular genetics. Thomashow has led the lab for the past nine years.

“Professor Benning is a distinguished plant biochemist with a strong record of disciplinary contributions,” said R. James Kirkpatrick, College of Natural Science (NatSci) dean. “I am looking forward to working with him to continue to build on the extraordinary legacy of the PRL and the plant sciences at MSU. I also want to thank Professor Thomashow for his outstanding leadership of the PRL. The laboratory continues to thrive in large measure due to his leadership in hiring outstanding faculty and redirecting the lab’s research as the scientific focus of the DOE changed.”

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Studying plant resilience in the face of climate change

MSU Today  online

2016-11-07

Michael Thomashow, a University Distinguished Professor in the Department of Plant, Soil and Microbial Sciences, saw this as an opportunity. He solicited the assistance of fellow MSU plant science experts Gregg Howe, Brad Day and Sheng Yang He to develop a project that addresses the growing world population’s need for more food produced with fewer resources under increasingly difficult conditions.

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Plants unpack winter coats when days get shorter, says MSU AgBioResearch scientist

MSU Today  online

2012-08-27

The CBF cold response pathway was discovered by Thomashow’s team, and it has been shown to be active in crop species as they ready themselves for cold weather.

“We knew that when plants are exposed to cold, nonfreezing temperatures, they can better survive below-freezing temperatures,” said Thomashow, university distinguished professor of molecular genetics and study co-author with Chin-Mei Lee, MSU plant biologist. “What this new research demonstrates, though, is that plants’ defense mechanisms are also triggered by shortening daylight.”

It’s widely known that waning daylight triggers trees’ defenses against freezing, but this has never been demonstrated in crops and other annual plants. The study not only shows that such plants use shorter days as a cue for the impending winter, but that the mechanism also is turned off during the warm growing season.

“The CBF pathway is actively turned off during the summer to prevent the allocation of precious resources toward unneeded frost protection,” Thomashow said.

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Journal Articles (5)

Regulation of the Arabidopsis CBF regulon by a complex low‐temperature regulatory network The Plant Journal

2015
Exposure of Arabidopsis thaliana plants to low non‐freezing temperatures results in an increase in freezing tolerance that involves action of the C‐repeat binding factor (CBF) regulatory pathway. CBF1, CBF2 and CBF3, which are rapidly induced in response to low temperature, encode closely related AP2/ERF DNA‐binding proteins that recognize the C‐repeat (CRT)/dehydration‐responsive element (DRE) DNA regulatory element present in the promoters of CBF‐regulated genes.

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Natural variation in the C‐repeat binding factor cold response pathway correlates with local adaptation of Arabidopsis ecotypes The Plant Journal

2015
The natural range of Arabidopsis thaliana (Arabidopsis) encompasses geographical regions that have greatly differing local climates, including harshness of winter temperatures. A question thus raised is whether differences in freezing tolerance might contribute to local adaptation in Arabidopsis.

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CIRCADIAN CLOCK-ASSOCIATED 1 and LATE ELONGATED HYPOCOTYL regulate expression of the C-REPEAT BINDING FACTOR (CBF) pathway in Arabidopsis Proceedings of the National Academy of Sciences

2011
The C-REPEAT BINDING FACTOR (CBF) cold-response pathway has a prominent role in cold acclimation, the process whereby certain plants increase tolerance to freezing in response to low nonfreezing temperatures. In Arabidopsis, the CBF pathway is characterized by rapid induction of the C-REPEAT BINDING FACTOR 1 (CBF1), CBF2, and CBF3 genes, which encode transcriptional activators, followed by induction of the CBF-targeted genes known as the “CBF regulon.” Expression of the CBF regulon results in an increase in freezing tolerance.

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Cis-regulatory code of stress-responsive transcription in Arabidopsis thaliana Proceedings of the National Academy of Sciences

2011
Environmental stress leads to dramatic transcriptional reprogramming, which is central to plant survival. Although substantial knowledge has accumulated on how a few plant cis-regulatory elements (CREs) function in stress regulation, many more CREs remain to be discovered. In addition, the plant stress cis-regulatory code, i.e., how CREs work independently and/or in concert to specify stress-responsive transcription, is mostly unknown.

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The Genome Sequence of Psychrobacter arcticus 273-4, a Psychroactive Siberian Permafrost Bacterium, Reveals Mechanisms for Adaptation to Low-Temperature Growth Applied and Environmental Microbiology

2010
Psychrobacter arcticus strain 273-4, which grows at temperatures as low as −10°C, is the first cold-adapted bacterium from a terrestrial environment whose genome was sequenced. Analysis of the 2.65-Mb genome suggested that some of the strategies employed by P. arcticus 273-4 for survival under cold and stress conditions are changes in membrane composition, synthesis of cold shock proteins, and the use of acetate as an energy source.

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