Nikolay Gerasimchuk
Professor, Chemistry | Missouri State University
Springfield, MO, UNITED STATES
Dr. Gerasimchuk's research is focused on the biological properties of cyanoximes, a new class of low molecular weight organic molecules.
Media
Publications:
Documents:
Videos:
Audio/Podcasts:
Biography
The main focus of Dr. Nikolay Gerasimchuk's scientific curiosity is chemistry and applications of oxime-bearing ligands and their metal complexes. Specifically he is interested in a new class of low molecular weight organic molecules - cyanoximes. Many cyanoximes and their metal derivatives have shown significant biological activity ranging from antimicrobial and cytotic, to growth regulation in plants and organophosphorous pesticides detoxifying agents (antidots).
The biological properties of these compounds is reflected in many of Gerasimchuk's patents, presentations and publications. One of the research projects his group is dedicated to is synthesis, characterization and in-vitro biological studies of antimicrobial activity (Ag complexes) and cytotoxicity (Pd, Pt; organotin(IV)) of a large group of previously unknown metallocyanoximates. This work is carried out in collaboration with Prof. Paul Durham from MSU Biology Department. Another project is dealing with preparation of coordination polymers with metal ions such as Tl(I) or Pt(II) in close special proximity to each other, often almost as close as distance in these metallic elements.
Industry Expertise (3)
Research
Chemicals
Pharmaceuticals
Areas of Expertise (7)
Cyanoximes
Chemistry
Science
Inorganic Chemistry
Crystallography
Biologically Active Compounds
Chemical Synthesis and Purification
Accomplishments (10)
The Atwood Research and Teaching Award (professional)
2016 Missouri State University
College of Natural and Applied Sciences Research Award (professional)
2015 Missouri State University
College of Natural and Applied Sciences Service Award (professional)
2014 Missouri State University
Missouri State University Foundation Award for Research (professional)
2014 Missouri State University
Certificate of Recognition from Program Chair for Extraordinary Contribution to the Success of 2013 Midwest Regional Meeting (professional)
2013 American Chemical Society
College of Natural and Applied Sciences Research Award (professional)
2012 Missouri State University
Best Undergraduate Research Student Mentor Award - 2nd Place Student Presentation (professional)
2011 Missouri State University
College of Natural and Applied Sciences Service Award (professional)
2006 Missouri State University
College of Natural and Applied Sciences Teaching Award (professional)
2005 Missouri State University
College of Natural and Applied Sciences Research Award (professional)
2004 Southwest Missouri State University
Education (4)
University of Kansas: Ph.D., Bioinorganic Chemistry 1996
Thesis: "Synthesis, Spectroscopic and Structural Studies of a new Family of Dipyrromethane Ligands and Their Manganese Complexes as Catalase Models.”
Kiev State University (Ukraine): Ph.D., Coordination Chemistry 1985
Kiev State University (Ukraine): M.S., Chemistry 1981
Kiev State University (Ukraine): B.S., Chemistry 1981
Affiliations (3)
- American Chemical Society (ACS)
- American Crystallographic Association (ACA)
- Midsouth Inorganic Chemists Association (MICA)
Links (6)
Languages (6)
- English
- Russian (mother tongue)
- Ukrainian (native)
- Spanish
- German
- Hungarian
Media Appearances (2)
Metals move front and center to target cancer
Missouri State Magazine
2016-06-01
As a child growing up in Ukraine, Dr. Nikolay Gerasimchuk, professor of chemistry, learned about science sitting at the kitchen table ...
Beakers, flasks and test tubes: the science of blowing glass
Missouri State University News online
2016-03-17
“Glass was made by fire,” said Dr. Nikolay Gerasimchuck, professor of chemistry at Missouri State University. “So, it can be treated and cut by fire.”...
Minds-Eye (1)
Metals move front and center to target cancer
The antimicrobial property of silver is one key to a current research project Dr. Gerasimchuk is conducting. He is developing a set of compounds that, when added in a small amount to light-curable polymeric medical adhesives, could be used to properly set medical indwelling devices and prevent infections at those sites.
Articles (6)
Anticancer, biophysical and computational investigations of half-sandwich ruthenium(II) thiosemicarbazone complexes: The effect of arene versus thiacrown face-cap
Interdisciplinary Journal of Chemistry
2016 A series of half-sandwich ruthenium complexes, two containing an arene face-cap and the other a thiacrown ether face-cap were synthesized to investigate the necessity of the arene for anticancer activity in this class of compounds.
New non-aggregating bivalent cis-ML 2 (M= Pd, Pt; L= pivaloylcyanoxime)
Inorganica Chimica Acta
2016 The 1-oximino-1-cyano-3-t-butyl-ketone (pivaloyl-cyanoxime), HPiCO, and its two new bivalent Pd, Pt complexes of the M(PiCO)2 composition were synthesized and characterized using UV–Vis, IR spectroscopic methods, TG/DSC and X-ray analysis...
1-D coordination polymer route to catalytically active Co@ C nanoparticles
RSC Advances
2016 Pyrolysis of a 1-D polymeric cobalt(II) coordination complex ([Co(BDC)(Mim)2]n, H2BDC = benzenedicarboxylic acid; Mim = N-methylimidazole) results in the formation of carbon embedded fcc cobalt nanoparticle composites, Co@C...
Temperature-dependent shape-responsive fluorescent nanospheres for image-guided drug delivery
Journal of Materials Chemistry C
2016 Temperature-responsive nanoparticles used in conjunction with hyperthermia promise to provide synergistic effects for increasing drug efficacy. We propose a near-infrared (NIR) fluorescent system based on a upper critical solution temperature (UCST) polymer, ISP2, integrated with a NIR fluorescent dye HITC for in vivo tracking...
First π-linker featuring mercapto and isocyano anchoring groups within the same molecule: synthesis, heterobimetallic complexation and self-assembly on Au (111)
Chemical Science
2016 Mercapto (–SH) and isocyano (–N[triple bond, length as m-dash]C) terminated conducting π-linkers are often employed in the ever-growing quest for organoelectronic materials...
[Fe–Fe] hydrogenase models: Iron(I)-carbonyl clusters coupled to alpha- and para-toluenethiolate ligands
Polyhedron
2016 Two linkage isomers composing of diironhexacarbonyl clusters coupled to α and p-toluenethiolate ligands have been usefully prepared in moderate yields. The composition of both compounds, [(μ2-(p-toluenethiolato))2Fe2(CO)6] (1) and [(μ2-(α-toluenethiolato))2Fe2(CO)6] (2), have been determined by elemental analysis and NMR spectroscopy. A tetrairondodecacarbonyl complex, [μ4-S(μ2-(α-toluenethiolato)Fe2(CO)6)2] (3), was isolated from the reaction mixture of 2. The molecular structures of 2 and 3 determined by X-ray diffraction are discussed.
Social