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Aston University atmospheric chemist praises introduction of Birmingham’s Clean Air Zone

Dr Stephen Worrall has praised the introduction of the Clean Air Zone in Birmingham The expert in atmospheric chemistry said current levels within the city have to drop for the health of all Birmingham’s Clean Air Zone (CAZ) comes into effect on 1 June Dr Stephen Worrall is a lecturer in chemistry at Aston University A leading atmospheric chemist from Aston University has welcomed the introduction of Birmingham’s Clean Air Zone (CAZ) from 1 June 2021 and has said it will be an important step in tackling air pollution. Dr Stephen Worrall, a lecturer in chemistry in the College of Engineering and Physical Sciences, said the long-term effects of the change will be beneficial to people’s health throughout the city. Air pollution particularly affects the most vulnerable in society, including children and older people, and those with heart and lung conditions. The annual health cost to society of the impacts of particulate matter alone in the UK is estimated to be around £16 billion*. Dr Worrall said: “In my opinion the CAZ is undoubtedly a good idea. In many of our cities, but definitely in Birmingham, the levels of many types of pollution and especially nitrogen dioxide (NO2) are high and have been above the guideline levels for a very long time, so it is welcome that these changes are happening.” Dr Worrall said current levels of NO2 in Birmingham in May 2021 have frequently exceeded 45 – 50 micrograms per cubic meter, mainly caused by road traffic emissions. The last reported yearly average for the city centre was as high as 74 micrograms per cubic meter, taken from the measuring site at St Chads Queensway. The primary aim of the CAZ is to reduce the levels of NO2 to 40 micrograms per cubic meter. “What is interesting about 2020 is those levels were still quite high at times despite us being into lockdown, when there were significantly fewer vehicles on the road. The live, daily readings from this year are also often exceeding the recommended levels, both of which are telling,” he said. Dr Worrall has significant experience in the subject, having spent a portion of his post-doctoral research in Beijing where he took live air pollution measurements, monitored problematic levels and discussed with international colleagues’ ways to address these issues. He said: “I was working and living in a very polluted area of the city and it was very noticeable on a daily basis how polluted it was. The levels of NO2 in 2017 while I was there were on average 103 micrograms per cubic meter, which was very high.” Dr Worrall added he believed the CAZ would have a big impact on Birmingham’s overall health but that the situation needed to be closely monitored. “There is significant evidence to suggest that there are serious long term health issues that arise from breathing in high levels of NO2, as well as Particle Matter (PM), an air pollutant which is absorbed into the blood stream through penetrating the lungs. These include asthma, bronchitis, lung cancer, heart disease and strokes. “Whilst there is local concern about the economic impact of the CAZ which must be taken into account, reducing these levels will benefit all of us, particularly those living in areas of deprivation who have been shown to be most significantly harmed by these high levels of pollution, as Birmingham’s biggest cause of pollution is from cars,” he said. Read more about College of Engineering and Physical Sciences at Aston University, here.

Laughing through lockdown: why comedy is important in times of crisis

Author: Lucy Rayfield Most of us have needed a good laugh over the last 12 months. Searches on Netflix for horror dipped at the peak of the first lockdown, while stand-up comedy saw a huge jump in viewers. In the world of social media, accounts poking fun at responses to the virus have also gained enormous followings, with accounts like Quentin Quarantino and the Reddit thread CoronavirusMemes surging in popularity in the past year. We’ve spent a significant amount of time joking about Zoom meetings, hand-washing songs, and home haircuts. But what makes us switch so quickly between panicking at death tolls and chuckling at a video sent by a friend? As a scholar who’s spent much of my career studying laughter and comedy, I often come across surprising functions of humour. I’ve studied Italian comedy and its reception in 16th-century France, the political consequences of laughter in the Wars of Religion, and the historical antecedents to today’s main theories of humour. We can help you make informed decisions with our independent journalism. Much of my research has revealed fascinating things about how humour appeals to us in times of hardship. But the pandemic has really amplified the roles that comedy can play and brought home our reliance on humour. Humour in ancient Rome Our need to laugh in the face of disaster is by no means new. In ancient Rome, gladiators would leave humorous graffiti on barrack walls before going to their deaths. The ancient Greeks also sought new ways to laugh at deadly disease. And during the Black Death pandemic in 1348, the Italian Giovanni Boccaccio wrote the Decameron, a collection of often funny tales told by storytellers isolating from the plague. Comedy scene in a Roman mosaic on display in the National Archaeological Museum in Naples, Italy. Azoor Photo/Alamy The need to avoid offence with humour is just as ancient. In 335 BCE, Aristotle advised against laughing at anything painful or destructive. The Roman educator Quintilian also outlined in 95 CE the very fine line between ridere (laughter) and deridere (derision). It’s still generally accepted a common position that humour shouldn’t hurt, and this is particularly true when the object of laughter is already vulnerable. When the boundary between laughter and derision is respected, comedy can play a key role in helping us to recover from disaster, providing benefits which explain our tendency to seek humour in serious situations, especially in terms of enhancing our sense of physical and mental wellbeing. How humour helps during crises Laughter serves as a great workout (laughing 100 times burns as many calories as 15 minutes on an exercise bike), helping to relax our muscles and promote circulation. Combinations of exercise and laughter — such as the increasingly popular “laughter yoga” — can also provide significant benefits to patients with depression. Laughter also decreases stress hormones and increases endorphins. In tough times, when we have thousands of thoughts a day, a bout of giggling provides our brains with respite we desperately need. Home haircuts were the source of a number of jokes during the first lockdown. Rosanne Tackaberr/Alamy In the same way, we seek humour in a crisis because it is difficult to feel scared and amused at the same time, and most often, the combination of these emotions result in feeling thrill and not terror. Sigmund Freud explored this in 1905 when revising the so-called “relief theory”, suggesting that laughter feels good because it purges our system of pent-up energy. Even in the 1400s, clerics argued that mirth was vital for keeping up spirits, explaining that people are like old barrels which explode if they aren’t uncorked from time to time. As levels of loneliness reached a record high during the winter lockdown (in November, one in four UK adults reported feeling lonely), laughter has also been crucial in bringing people together. Not only is it typically a communal activity – some scientists believe that our human ancestors laughed in groups before they could speak – it’s even more contagious than yawning. Given that we’re far more likely to laugh at topics we find personally relatable, humour has helped people to identify with one another during lockdowns. This in turn creates a sense of unity and solidarity, alleviating our sense of disconnectedness. Literature scholar and author Gina Barreca maintains that “laughing together is as close as you can get without touching”. Laughter can also be a means of easing our worries. Joking around a fear, especially during a pandemic, can make it more manageable, a phenomenon known by comedians as “finding the funny”. This is linked to “superiority theory”, the idea that we laugh because we feel superior to something or someone else (for example, it’s funny when someone slips on a banana because we ourselves haven’t). We laugh because we are superior, unthreatened, and in control. In this way, joking about a virus heightens our sense of power over it and relieves anxiety. Joking can also be useful because it enables us to talk about our problems and to express fears we may otherwise find hard to put into words. Though many of us have felt guilty for seeking humour in the pandemic, let’s not add this to our list of worries. Certainly, our situation may not always be a laughing matter. But laughing itself matters, and when used appropriately, it can be one of our most effective coping mechanisms during a crisis, allowing us to find a healthier balance with others, with ourselves, and even with events beyond our control.

US call to boycott Beijing Olympics: expert available

US House speaker Nancy Pelosi has called for a international boycott of the Beijing Winter Olympics in 2022, in response to reports of human rights abuses by the Chinese government. Professor Shaun Breslin, an expert on China from the University of Warwick (UK), is AVAILBLE FOR INTERVIEW and media-friendly. He comments: "While the messenger can control what message they send, they cannot control the way that it will be understood and parsed by the recipient. This is intended to show to the Chinese leadership the level of global revulsion at what is going on in Xinjiang – and perhaps with the restrictions on individual freedoms more generally in China; including in Hong Kong – this is likely to be perceived differently in Beijing. Or at least, the message will be explained as having a different meaning to the Chinese people. This will be used as further evidence that the US (and its allies) do not want to accommodate China’s rise into the existing international order, and are trying to find ways of checking China’s rise. The Chinese government repeatedly argues that China is being 'smeared' or 'slandered' by the west and this is likely to be the response this time too. "This is, of course, not the first time that the Olympics has become an international relations issue for China. There was a feeling that the country had been slighted in 1993 when the millennial Olympic Games was awarded to Sydney despite a widespread expectation (and not just in China) that Beijing would win, and this would be a validation of China’s re-acceptance into the international community. And when they did win and host the games (in 2008), this was used to showcase a new self confident and increasingly powerful China to the world; a sort of coming out party for China as a putative great power." For interviews, contact: Luke Walton, International Press Manager L.Walton.1@warwick.ac.uk +44 (0) 7823 362 150

UMW Professor Jason Davidson speaks to The Guardian about ‘Costs of War’ in Afghanistan

As America readies to end its military presence in Afghanistan, there’s been much reflection and examining of the role America and its NATO allies played in the war-torn country. A report released just this week shed some light and much-needed perspective on the topic. University of Mary Washington Professor of Political Science and International Affairs Jason Davidson, the study's author, was contacted by The Guardian to lend his expert opinion. “British and Canadian troops were more than twice as likely to get killed in Afghanistan as their US counterparts, according to a study that looks at the scale of the sacrifice made by Nato allies over the course of the 20-year war. The UK also gave more to Afghanistan than the US in the form of economic and humanitarian assistance as a percentage of GDP, the study published on Wednesday by the Costs of War project at Brown University in the US found. Although the US suffered by far the greatest number of fatalities in absolute terms compared with other members of the International Security Assistance Force (ISAF) – 2,316 American troops were killed between 2001 and 2017, the period of the study – Canadians and British soldiers sent to Afghanistan were more likely to die. The Costs of War report looks at fatalities as a percentage of national troop levels at peak deployment in Afghanistan. The US losses were 2.3% of its vast military presence. The UK lost 455 lives, which was 4.7% of its peak deployment level, while the 158 Canadians killed represented 5.4% of their total. The study refers to a grim joke told by American soldiers in Afghanistan that ISAF stood for “I Saw Americans Fight”, but points out in the case of the UK and Canada at least it was grossly unfair. “Americans do not fully understand, do not acknowledge, the sacrifices that allies made in Afghanistan,” said Jason Davidson, the author of the report, and professor of political science and international affairs at the University of Mary Washington. “It’s something that not only doesn’t get attention from those who are critics of the allies. It doesn’t even get the attention that it deserves from those who are generally cheerleaders for allies, like the current administration. I would like to see more American policymaker acknowledgment and discussion with the public of the costs that America’s allies have incurred in these wars.” May 12 - The Guardian There will be a lot of coverage in the lead up to America’s exit from Afghanistan, and if you are a reporter looking to cover that topic or the ‘Costs of War’ project, then let us help. Dr. Jason Davidson is a professor of Political Science and International Affairs and is also an expert in American Foreign and Security Policy, and International Security. If you’re looking to arrange an interview with Dr. Davidson, simply click on his icon now to arrange an interview today.

Queen's Speech: Measures to tackle obesity and food advertising bans

Two University of Warwick experts comment on measures to tackle obesity and food advertising that have been announced in the Queen’s Speech at the State Opening of the UK Parliament today. Dr Paul Coleman (pictured), from Warwick Medical School and the Warwick Obesity Network, said: We welcome the government's intention to tackle rising rates of obesity by restricting the advertising of products high in fat, sugar or salt (HFSS) shown on TV before 9pm and a total online advertising ban However, the government must focus on all forms on online advertising, not simply traditional commercials. This ban must cover online ‘advergames’, which encourage children to win points by placing branded food item in the mouth of children’s characters. These games are notoriously difficult for the government to regulate. While we also welcome the decision to incentivise individuals to both eat better and exercise more, the government must recognise that increased wages, rather than one-off payments, are needed to ensure all families can access healthy food For many families the main barrier in purchasing healthy food is cost, with families regularly limiting the amount of money spent on food to cover the cost of other essentials. All families require the financial means to purchase healthy food. We would like to see new targets to end household food insecurity by the year 2030. Dr Thijs van Rens of the University of Warwick Department of Economics and the Warwick Obesity Network, said: Required calorie labelling for large out-of-home businesses is a welcome start to address the restaurant and take-away sector, where many people get a large and increasing share of their food. A ban on "junk food" advertising on TV and online is long overdue. While we welcome the government renewed commitment to announce a ban on advertising, it is now time to take action. We are still waiting on the government to publish the result of its consultation on this matter, which was announced in November of last year. In the meantime, overweight and obesity are set to overtake smoking as the biggest cause of preventable death in the UK. Overweight is the silent killer that we can do something about, just as deadly as Covid-19 and much more under our control. Advertising is one of the elements of an environment that nudges, forces and tricks parents and children into buying and consuming food that makes them unhealthy, overweight and eventually kills them. Effective action against HFSS food advertising means banning advertising anywhere where children are likely to see it, which means both on telly and online

Thousands of men to trial prostate cancer home testing kit

Thousands of men worldwide are to receive a home test kit for prostate cancer – thanks to pioneering research from the University of East Anglia and the Norfolk and Norwich University Hospital (NNUH). The research team are trialling a new home-testing ‘Prostate Screening Box’ to collect men’s urine samples at-home. The urine samples will be used to analyse the health of the prostate in 2,000 men in the UK, Europe and Canada. This simple urine test is intended to diagnose aggressive prostate cancer and in a pilot study predicted which patients required treatment up to five years earlier than standard clinical methods. Lead researcher Dr Jeremy Clark from the University of East Anglia 'unboxes' the new home testing kit live on Sky News. The Prostate Screening Box has been developed in collaboration with REAL Digital International Limited to create a kit that fits through a standard letterbox. It means that men can provide a urine sample in the comfort of their own home, instead of going into a clinic or having to undergo an uncomfortable rectal examination. The research team hope that it could revolutionise diagnosis of the disease. Lead researcher Dr Jeremy Clark, from UEA’s Norwich Medical School, said: “Prostate cancer is the most common cancer in men in the UK. However it usually develops slowly and the majority of cancers will not require treatment in a man’s lifetime. It is not a simple matter to predict which tumours will become aggressive, making it hard to decide on treatment for many men. “The most commonly used tests for prostate cancer include blood tests, a physical examination known as a digital rectal examination (DRE), an MRI scan or a biopsy. “We have developed the PUR (Prostate Urine Risk) test, which looks at gene expression in urine samples and provides vital information about whether a cancer is aggressive or ‘low risk’. “The Prostate Screening Box part sounds like quite a small innovation, but it means that in future the monitoring of cancer in men could be so much less stressful for them and reduce the number of expensive trips to the hospital. “The prostate lies just below the bladder. It constantly produces secretions which naturally flow into the urethra - the tube through which urine passes from the bladder. The prostatic secretions carry cells and molecules from all over the prostate which are flushed out of the body on urination. We collect these and examine them. It’s a way of sampling the whole prostate in one go. “As the prostate is constantly secreting, the levels of biomarkers in the urethra will build up with time. Collecting from the first wee of the day means that overnight secretions can be collected which makes the analysis more sensitive.” The team have previously trialled the kit with a small group of participants, but in the next phase of the research study are rolling it out to thousands. Men taking part in the trial will receive a home urine-sampling kit and will be asked to provide two urine samples – one to be taken first thing in the morning and the second an hour later. The samples will then be sent back to the lab for analysis. Dr Clark said: “Feedback from early participants showed that the at-home collection was much preferred over sample collection in a hospital. “We hope that using our Prostate Screening Box could in future revolutionise how those on ‘active surveillance’ are monitored for disease progression, with men only having to visit the clinic after a positive urine result. “This is in contrast to the current situation where men are recalled to the clinic every six to 12 months for a range of tests including DRE, PSA tests, painful and expensive biopsies and MRI. We are working to develop the test to help patients in three years’ time. “A negative test could enable men to only be retested every two to three years, relieving stress to the patient and reducing hospital workload,” he added. Robert Mills, Consultant Clinical Director in Urology at NNUH, said: “This simple, non-invasive urine test has the potential to significantly change how we diagnose and manage early prostate cancer for the benefit of patients and health care systems. It may enable us to avoid unnecessary diagnosis of low risk disease as well as managing patients more appropriately with surveillance for those with low risk of progression and early curative treatment for those at high risk of progression.” Paul Villanti, executive director of programs at Movember, said: “The PUR test has great potential to transform the way prostate cancer is managed. Not only can it accurately predict when a man’s disease will become aggressive and require treatment, but it has the added advantage of allowing men to complete it at home. “We are proud to have supported the development of the PUR test from its early stages as part of our Global Action Plan on Biomarkers, through to this trial involving thousands of men across the world. “Through our Global Action Plan on active surveillance, we have been able to identify hundreds of men from the UK, Germany, Italy and Canada who are suitable to take part in this trial. “We hope it will speed up the trial’s progress and get this test included as part of clinical care for men as quickly as possible.” The research has been funded by a Movember and Prostate Cancer UK Innovation award, the Masonic Charitable Foundation, the Bob Champion Cancer Trust, the King family, the Andy Ripley Memorial Fund, the Hargrave Foundation, Norfolk Freemasons and the Tesco Centenary Grant.

Autonomous cars expert: Dr Siddartha Khastgir

For stories on autonomous vehicles, Dr Siddartha Khastgir from WMG at the University of Warwick is one of the leading experts in the UK, and is available for comment.  His recent notable research includes developing the world’s largest public database for testing driverless cars: If you would like to interview him, contact press@warwick.ac.uk or L.Walton.1@warwick.ac.uk

New prostate cancer urine test shows how aggressive disease is and could reduce invasive biopsies

Researchers from the University of East Anglia have developed a new urine test for prostate cancer which also shows how aggressive the disease is. A new study shows how an experimental new test called ‘ExoGrail’ has the potential to revolutionise how patients with suspected prostate cancer are risk-assessed prior to an invasive biopsy. The research team say their new test could reduce the number of unnecessary prostate cancer biopsies by 35 per cent. Prostate cancer is the most common cancer in men in the UK. It usually develops slowly and the majority of cancers will not require treatment in a man’s lifetime. The most commonly used tests for prostate cancer include blood tests, a physical examination known as a digital rectal examination (DRE), an MRI scan or an invasive biopsy. However, doctors struggle to predict which tumours will become aggressive, making it hard to decide on treatment for many men. Lead researcher Dr Dan Brewer, from UEA’s Norwich Medical School, said: “While prostate cancer is responsible for a large proportion of all male cancer deaths, it is more commonly a disease men die with rather than from. “Therefore, there is a desperate need for improvements in diagnosing and predicting outcomes for prostate cancer patients to minimise over-diagnosis and overtreatment whilst appropriately treating men with aggressive disease, especially if this can be done without taking an invasive biopsy. “Invasive biopsies come at considerable economic, psychological and societal cost to patients and healthcare systems alike.” The research team developed the new ExoGrail urine test by combining two biomarker sources - measurements of a protein-marker called EN2 and the levels of gene expression of 10 genes related to prostate cancer risk. It builds on previously developed tests called PUR and ExoMeth. They tested it using urine samples from 207 patients who had been undergone a biopsy for prostate cancer at the Norfolk and Norwich University Hospital (NNUH). When the urine results were compared to biopsy results, the study showed that the test had successfully shown which patients had prostate cancer and which did not. The ExoGrail test also provided risk scores for patients and highlighted those for which an invasive biopsy would have been beneficial. The findings show that using information from multiple, non-invasive biomarker sources has the potential to greatly improve how patients with suspected prostate cancer are risk-assessed prior to an invasive biopsy. Dr Brewer said: “Our new urine test not only shows whether a patient has prostate cancer, but it importantly shows how aggressive the disease is. This allows patients and doctors to select the correct treatment. And it has the potential to reduce the number of unnecessary biopsies by 35 per cent.” The research team was led by Dr Shea Connell, Prof Colin Cooper, Dr Daniel Brewer and Dr Jeremy Clark, all from UEA’s Norwich Medical School, in collaboration with the Norfolk and Norwich University Hospital, the University of Surrey, the University of Bradford, The Earlham Institute, and The Movember GAP1 Urine Biomarker Consortium. The urine biomarker research was funded by the Movember GAP1 Urine Biomarker project, Prostate Cancer UK, The Masonic Charitable Foundation, The Bob Champion Cancer Trust, the King family, The Andy Ripley Memorial Fund, the Hargrave Foundation, Norfolk Freemasons and the Tesco Centenary Grant. Paul Villanti, executive director of programmes at Movember, said: “We are proud to have supported the development of the ExoGrail urine test as part of our Global Action Plan Urine Biomarker project. “Having non-invasive tests which can accurately show how aggressive a man’s prostate cancer is not only reduces the number of men having to undergo painful biopsies, but also ensures that the right course of treatment for the patient is selected more quickly.” ‘Integration of Urinary EN2 Protein & Cell-Free RNA Data in the Development of a Multivariable Risk Model for the Detection of Prostate Cancer Prior to Biopsy’ is published in the journal Cancers on Tuesday, April 27, 2021.

Novel coronavirus discovered in British bats

A coronavirus related to the virus that causes Covid-19 in humans has been found in UK horseshoe bats – according to new collaborative research from the University of East Anglia, ZSL (Zoological Society of London), and Public Health England (PHE). However, there is no evidence that this novel virus has been transmitted to humans, or that it could in future, unless it mutates. UEA researchers collected faecal samples from more than 50 lesser horseshoe bats in Somerset, Gloucestershire and Wales and sent them for viral analysis at Public Health England. Genome sequencing found a novel coronavirus in one of the bat samples, which the team have named ‘RhGB01’. Due to the rapid response nature of this research, it has not yet been peer reviewed. It is the first time that a sarbecovirus (SARS-related coronavirus) has been found in a lesser horseshoe bat and the first to be discovered in the UK. The research team say that these bats will almost certainly have harboured the virus for a very long time. And it has been found now, because this is the first time that they have been tested. Importantly, this novel virus is unlikely to pose a direct risk to humans, unless it mutates. A mutation could happen if a human infected with Covid-19 passes it to an infected bat, so anyone coming into contact with bats or their droppings, for example those engaged in caving or bat protection, should wear appropriate PPE. Prof Diana Bell, an expert in emerging zoonotic diseases from UEA’s School of Biological Sciences, said: “Horseshoe bats are found across Europe, Africa, Asia and Australia and the bats we tested lie at the western extreme of their range. “Similar viruses have been found in other horseshoe bat species in China, South East Asia and Eastern Europe. “Our research extends both the geographic and species ranges of these types of viruses and suggests their more widespread presence across more than 90 species of horseshoe bats. “These bats will almost certainly have harboured this virus for a very long time – probably many thousands of years. We didn’t know about it before because this is the first time that such tests have been carried out in UK bats. “We already know that there are different coronaviruses in many other mammal species too,” she said. “This is a case of ‘seek and you will find’. “Research into the origins of SARS-CoV-2, the virus that causes Covid-19 in humans, has focussed on horseshoe bats - but there are some 1,400 other bat species and they comprise 20 per cent of known mammals. “Our findings highlight the need for robust genotype testing for these types of viruses in bat populations around the world. And it raises an important question about what other animals carry these types of viruses.” Prof Andrew Cunningham, from the Zoological Society of London, said: “Our findings highlight that the natural distribution of sarbecoviruses and opportunities for recombination through intermediate host co-infection have been underestimated. “This UK virus is not a threat to humans because the receptor binding domain (RBD) – the part of the virus that attaches to host cells to infect them - is not compatible with being able to infect human cells. “But the problem is that any bat harbouring a SARS-like coronavirus can act as a melting pot for virus mutation. So if a bat with the RhGB01 infection we found were to become infected with SARS-CoV-2, there is a risk that these viruses would hybridise and a new virus emerge with the RBD of SARS-CoV-2, and so be able to infect people. “Preventing transmission of SARS-CoV-2 from humans to bats, and hence reducing opportunities for virus mutation, is critical with the current global mass vaccination campaign against this virus.” Prof Bell added: “The main risks would be for example a bat rehabilitator looking after a rescued animal and infecting it with SARS-CoV2 - which would provide an opportunity for genetic recombination if it is already carrying another sarbecovirus. “Anyone coming into contact with bats or their droppings, such as bat rescuers or cavers, should wear appropriate PPE – in order to reduce the risk of a mutation occurring. “We need to apply stringent regulations globally for anyone handling bats and other wild animals,” she added. The new virus falls within the subgroup of coronaviruses called sarbecoviruses which contains both SARS-CoV-2 (responsible for the current pandemic) and SARS-CoV (responsible for the initial 2003 SARS outbreak in humans). Further analysis compared the virus with those found in other horseshoe bat species in China, South East Asia and Europe and showed that its closest relative was discovered in a Blasius’s bat from Bulgaria in 2008. Ivana’s story The UK discovery was made by undergraduate ecology student Ivana Murphy, from UEA’s School of Biological Sciences, who collected bat droppings as part of her final year research dissertation. Jack Crook conducted the genetic analyses in partnership with other researchers at PHE. A total of 53 bats were captured, and their faeces collected in sterile bags. The research was conducted under strict Health and Safety protocols. Full PPE was worn and Ivana was regularly tested for Covid-19 to avoid any chance of cross contamination. The bats were released immediately after their droppings had been collected. Ivana said: “I am very fortunate to be surrounded by so many experts in their fields, which has allowed me access to resources that many undergraduates wouldn’t have. I feel extremely lucky to have been able to conduct such an advanced study.” “We weren’t shocked by the results, but I am extremely eager to carry out further research. “I chose to study ecology at UEA as I have a passion for trying to protect and conserve nature. I wanted a better understanding of the global situation and so chose UEA to study ecology and conservation. “The plan after graduation is to do an extended study of viruses in UK bats, very similar to the one I carried out as an undergraduate. There is still a lot more to understand and I am extremely excited to see what else we can find out.” But she says that she doesn’t want her research to turn people against bats. “More than anything, I’m worried that people may suddenly start fearing and persecuting bats, which is the last thing I would want and would be unnecessary. As like all wildlife, if left alone they do not pose any threat.” ‘Metagenomic identification of a new sarbecovirus from horseshoe bats in Europe’ is published on the Research Square pre-print server. Read the full story, including a Q&A with all you need to know.

Smell training, not steroids, best treatment for Covid-19 smell loss

Steroids should not be used to treat smell loss caused by Covid-19 according to an international group of smell experts, including Prof Carl Philpott from the University of East Anglia. Smell loss is a prominent symptom of Covid-19, and the pandemic is leaving many people with long-term smell loss. But a new study published today shows that corticosteroids - a class of drug that lowers inflammation in the body – are not recommended to treat smell loss due to Covid-19. Instead, the team recommend ‘smell training’ – a process that involves sniffing at least four different odours twice a day for several months. Smell loss expert Prof Carl Philpott from UEA’s Norwich Medical School, said: “The huge rise in smell loss caused by Covid-19 has created an unprecedented worldwide demand for treatment. “Around one in five people who experience smell loss as a result of Covid-19 report that their sense of smell has not returned to normal eight weeks after falling ill. “Corticosteroids are a class of drug that lowers inflammation in the body. Doctors often prescribe them to help treat conditions such as asthma, and they have been considered as a therapeutic option for smell loss caused by Covid-19. “But they have well-known potential side effects including fluid retention, high blood pressure, and problems with mood swings and behaviour.” The team carried out a systematic evidence-based review to see whether corticosteroids could help people regain their sense of smell. Prof Philpott said: “What we found that there is very little evidence that corticosteroids will help with smell loss. And because they have well known potential adverse side effects, our advice is that they should not be prescribed as a treatment for post-viral smell loss. "There might be a case for using oral corticosteroids to eliminate the possibility of another cause for smell loss actually being a confounding factor, for example chronic sinusitis – this is obviously more of a diagnostic role than as a treatment for viral smell loss. “Luckily most people who experience smell loss as a result of Covid-19 will regain their sense of smell spontaneously. Research shows that 90 per cent of people will have fully recovered their sense of smell after six months. “But we do know that smell training could be helpful. This involves sniffing at least four different odours twice a day every day for several months. It has emerged as a cheap, simple and side-effect free treatment option for various causes of smell loss, including Covid-19. “It aims to help recovery based on neuroplasticity - the brain’s ability to reorganise itself to compensate for a change or injury,” he added. The research was led by researchers at the Cliniques universitaires Saint-Luc in Brussels (Belgium) in collaboration with the Univeristé catholique de Louvain, Brussels (Belgium), the University of East Anglia (UK), Biruni University, Istanbul (Turkey), Aarhus University (Denmark), Université du Québec à Trois-Rivières (Canada), Geneve University Hospitals (Switzerland), Harvard University (USA), Aristotle University, Thessaloniki (Greece), University of Insubriae (Italy), University of Vienna (Austria), the University of Chicago (USA) and the University of Colorado (USA). ‘Systemic corticosteroids in COVID-19 related smell dysfunction: an international view’ is published in the journal International Forum of Allergy & Rhinology.