How do you separate home from work when it comes to keeping computers safe?
The best way to keep work materials safe would be to have a separate device that is used only for work, such as a company-supplied laptop. Since most of us will not have devices supplied to us, the next best would be to use a device that has minimal other use:
Try not to use a computer that the rest of the family uses.
If others use the computer, create a new user login and use that for work only.
Keep all your work files in an encrypted folder.
Ensure you have security software installed on the computer you are using for work.