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Amanda Burkhardt, PhD - USC School of Pharmacy. Los Angeles, CA, US

Amanda Burkhardt, PhD Amanda Burkhardt, PhD

Assistant Professor of Clinical Pharmacy | USC School of Pharmacy

Los Angeles, CA, UNITED STATES

An immunology researcher and educator with experience working in both basic and translational science.

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Biography

Prior to joining the USC School of Pharmacy faculty, Dr. Amanda M. Burkhardt was an Adjunct Assistant Professor at the University of California, Irvine in the School of Medicine, Department of Physiology & Biophysics; and Lecturer in the Department of Biological Sciences at California State University, Long Beach. Dr. Burkhardt holds a B.S. in Microbiology from the University of California, San Diego, and a Ph.D. in Immunology from the University of California, Irvine.

Her research career has focused on the development of novel vaccines and adjuvants, discovery of cytokines and chemokines, and tuning immune responses to vaccine formulations using adjuvants based on Toll-Like Receptors and nanoparticles.

Dr. Burkhardt has lectured and mentored doctoral, undergraduate and medical students, developed engaging course curriculum, and authored multiple patents and journal articles based on her findings.

Areas of Expertise (5)

Chemokines

Vaccine Immunology

Immunology

Vaccines

Cytokines

Education (2)

University of California, Irvine: PhD, Immunology

University of California, San Diego: BS, Microbiology

Affiliations (2)

  • Member, The American Association of Immunologists: 2012 to present
  • Member, Federation of Clinical Immunologists: 2012 to present

Selected Articles (7)

Tuning Subunit Vaccines with Novel TLR Triagonist Adjuvants to Generate Protective Immune Responses against Coxiella burnetii The Journal of Immunology

2019

Coxiella burnetii is an obligate intracellular bacterium and the causative agent of Q fever. C. burnetii is considered a potential bioterrorism agent because of its low infectious dose; resistance to heat, drying, and common disinfectants; and lack of prophylactic therapies. Q-Vax, a formalin-inactivated whole-bacteria vaccine, is currently the only prophylactic measure that is protective against C. burnetii infections but is not U.S. Food and Drug Administration approved.

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CCL28 Is Involved in Mucosal IgA Responses, Olfaction, and Resistance to Enteric Infections Journal of Interferon & Cytokine Research

2019

CCL28 is a mucosal chemokine that has been involved in various responses, including IgA production. We have analyzed its production in human tissues using a comprehensive microarray database. Its highest expression is in the salivary gland, indicating that it is an important component of saliva. It is also expressed in the trachea, bronchus, and in the mammary gland upon onset of lactation.

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Linked Toll-Like Receptor Triagonists Stimulate Distinct, Combination-Dependent Innate Immune Responses American Chemical Society

2019

Traditional vaccination strategies have failed to generate effective vaccines for many infections like tuberculosis and HIV. New approaches are needed for each type of disease. The protective immunity and distinct responses of many successful vaccines come from activating multiple Toll-like receptors (TLRs).

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Identification of IL-40, a Novel B Cell–Associated Cytokine The Journal of Immunology

2017

We describe a novel B cell-associated cytokine, encoded by an uncharacterized gene (C17orf99; chromosome 17 open reading frame 99), that is expressed in bone marrow and fetal liver and whose expression is also induced in peripheral B cells upon activation. C17orf99 is only present in mammalian genomes, and it encodes a small (∼27-kDa) secreted protein unrelated to other cytokine families, suggesting a function in mammalian immune responses.

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Cutting Edge: GPR35/CXCR8 Is the Receptor of the Mucosal Chemokine CXCL17 The Journal of Immunology

2015

Chemokines are chemotactic cytokines that direct the traffic of leukocytes and other cells in the body. Chemokines bind to G protein–coupled receptors expressed on target cells to initiate signaling cascades and induce chemotaxis. Although the cognate receptors of most chemokines have been identified, the receptor for the mucosal chemokine CXCL17 is undefined. In this article, we show that GPR35 is the receptor of CXCL17.

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METEORIN-LIKE is a cytokine associated with barrier tissues and alternatively activated macrophages Clinical Immunology

2014

Cytokines are involved in many functions of the immune system including initiating, amplifying and resolving immune responses. Through bioinformatics analyses of a comprehensive database of gene expression (BIGE: Body Index of Gene Expression) we observed that a small secreted protein encoded by a poorly characterized gene called meteorin-like (METRNL), is highly expressed in mucosal tissues, skin and activated macrophages.

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Homeostatic chemokine receptors and organ-specific metastasis Nature Reviews Immunology

2011

Evidence that homeostatic chemokines determine metastatic destinations has come from mouse models, in which blocking certain homeostatic chemokine receptors blocks metastasis, and from retrospective human studies, in which the expression of a chemokine receptor is associated with metastasis to a given organ and/or poor prognosis.

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