Angela Crawley

Scientist, Chronic Disease Program Ottawa Hospital Research Institute, Chronic Disease Program

Ottawa ON

Angela Crawley's lab studies the immunopathogenesis of HIV and hepatitis C (HCV) infection.

Social

Biography

Dr. Crawley has been with the Chronic Diseases Program at the Ottawa Hospital Research Institute since April 2012. In addition to being a Scientist with the OHRI, she is also an Assistant Professor at the University of Ottawa and Carleton University, where she teaches immunology at the undergraduate, graduate and medical school levels. She teaches these courses in both English and French. Dr. Crawley has earned 2 salary awards: a CIHR New Investigator Award and an Ontario HIV Treatment Network (OHTN) Junior Investigator Development Award. Her research is funded by the OHTN, Canadian Foundation of AIDS Research,, the J.P. Bickell Medical Research Foundation and the Natural Sciences and Engineering Research Council.

Dr. Crawley received a B.Sc. in Microbiology and Immunology from McGill University in Montreal, Quebec (Canada) in 1999. In 2004 she completed a Ph.D. in Immunology with Dr. Bruce N. Wilkie in the Dept. of Pathobiology at the University of Guelph’s Ontario Veterinary College (Guelph, Ontario, Canada). Dr. Crawley then trained as a postdoctoral fellow in Dr. Jonathan B. Angel’s laboratory at the Ottawa Hospital Research Institute, and published 10 peer-reviewed scientific research and review articles on the immunopathogenesis of HIV infection. Dr. Crawley was funded by an Ontario HIV Treatment Network (OHTN) Fellowship award and awarded a University of Ottawa Faculty of Medicine Postdoctoral Award of Excellence (2007).

Industry Expertise

Research

Education/Learning

Areas of Expertise

Biomedical Research

Immunology

Chronic Disease

T-cell biology

Hepatitis C Virus Infection (Hcv)

HIV-HCV co-infection

Liver disease

Hepatocellular Carcinoma (HCC)

Medical Research

Immunotherapy

Microbiology

University Teaching

Accomplishments

New Investigator Award

Canadian Institutes of Health Research
Salary award (2013-2018)

Research Funding (2011-present)

- Natural Sciences and Engineering Research Council
- Ontario HIV Treatment Network
- Canadian Foundation of AIDS Research
- J.P. Bickell Foundation
- Canadian Hepatitis C Network (student scholarships)

Junior Investigator Development Award

2011-01-01

Ontario HIV Treatment Network
Salary award and Research funding (2011-2015)

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Education

McGill University

B.S.

Microbiology and Immunology

1999

University of Guelph

Ph.D.

Immunology

2004

Affiliations

Assistant Professor University of Ottawa Dept. Biochem. Microbiol. Immunol.
Adjunct Professor Carleton University Dept. Biol.

Languages

English
French

Media Appearances

Ottawa student wins national science contest

Ottawa Citizen

2015-05-26

One lab after another turned him down until Angela Crawley of the Ottawa Hospital Research Institute took him in. She does HIV work ...

Articles

The influence of HIV on CD127 expression and its potential implications for IL-7 therapy

Seminars in Immunology

2012

Interleukin-7 (IL-7) is critical for early T-cell development and plays an important role in T-cell homeostasis, differentiation and function. Signalling via the IL-7 receptor is dependent on the expression of its components, IL-7Rα (CD127) and IL-2Rγ (CD132) and is mediated in part by alterations in CD127 expression levels in different cell subsets.

Jak/STAT and PI3K signaling pathways have both common and distinct roles in IL-7-mediated activities in human CD8+ T cells

Journal of Leukocyte Biology

2014

IL-7 plays an important role in T cell survival, function, and memory cell development, yet the role of cytokine signaling pathways in these processes has not been fully elucidated. Moreover, the underlying mechanisms for the observed impairment of IL-7 activity in diseases, such as HIV infection, breast cancer, and autoimmunity, are not well understood.

Complexed soluble IL-7 receptor α and IL-7 increase IL-7-mediated proliferation and viability of CD8⁺ T-cells in vitro

Cellular Immunology

2015

Many soluble cytokine receptors inhibit cytokine bioactivity, while others prolong ligand activity. The biological role of an endogenous soluble form of IL-7Rα, or its therapeutic effects on CD8+ T-cells are unknown. We demonstrate that recombinant IL-7Rα-Fc, when pre-incubated with IL-7, enhances IL-7-induced CD8+ T-cell proliferation and viability of human or murine CD8+ T-cells.