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Anna-Lisa Paul

Director | Professor University of Florida

  • Gainesville FL

Anna-Lisa Paul’s research focuses on molecular genetic responses of plants to spaceflight and planetary exploration-relevant environments.

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Biography

Anna-Lisa Paul is the Director of the Interdisciplinary Center for Biotechnology Research and a research Professor of Horticultural Sciences in the program of Plant Molecular and Cellular Biology. She is part of the UF-Research senior executive group and is chair of the Astraeus Space Institute Administrators council. Anna Lisa’s research focuses on plant gene expression in response to environmental change relevant to space exploration. Anna-Lisa uses orbital and suborbital environments to study the molecular genetic/epigenetic responses of plants to spaceflight and the transition to space, worked in extreme terrestrial environments, and worked with true lunar regolith from the Apollo era. Paul serves on two National Academies Committees associated with space exploration research.

Areas of Expertise

Astrobotany
Moon habitats
Luna regolith
Exploration science
Space molecular genetics
Space plant biology
Space transcriptome
Planetary analogs
Mars habitats
Planetary greenhouse

Media Appearances

Seeding Exploration

Florida Trend  online

2025-05-07

UF scientists Rob Ferl and Anna-Lisa Paul preach teamwork. That approach helped them take a giant leap for interplanetary exploration.

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Humans are explorers — go boldly

TED  online

2019-04-01

Humans are explorers, and space is what is next. Plants allows us to explore past the limits of a picnic basket to destinations beyond Earth’s orbit. In this talk, Research Professor Dr. Anna-Lisa Paul plants the seeds to a future of agriculture in space.

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Space Plants

Shorthand Social  online

2017-03-03

Anna-Lisa Paul's hands are steady. The pressure to plant 20 to 30 seeds in a tiny petri dish using a water dropper in under 10 minutes doesn’t faze her. Granted, the University of Florida plant molecular biologist has been doing this for "20 odd years."

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Articles

Plants grown in Apollo lunar regolith present stress-associated transcriptomes that inform prospects for lunar exploration

Nature Communications Biology

Paul, et al.

2022-05-12

The extent to which plants can enhance human life support on other worlds depends on the ability of plants to thrive in extraterrestrial environments using in-situ resources. Using samples from Apollo 11, 12, and 17, we show that the terrestrial plant Arabidopsis thaliana germinates and grows in diverse lunar regoliths. However, our results show that growth is challenging; the lunar regolith plants were slow to develop and many showed severe stress morphologies.

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Transcriptomic dynamics in the transition from ground to space are revealed by Virgin Galactic human-tended suborbital spaceflight

Nature npj Microgravity

Ferl, et al.

2023-12-20

The Virgin Galactic Unity 22 mission conducted the first astronaut-manipulated suborbital spaceflight experiment. The experiment examined the operationalization of Kennedy Space Center Fixation Tubes (KFTs) as a generalizable approach to preserving biology at various phases of suborbital flight.

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Light has a principal role in the Arabidopsis transcriptomic response to the spaceflight environment

Nature npj Microgravity

Zhou, et al.

2024-08-06

The Characterizing Arabidopsis Root Attractions (CARA) spaceflight experiment provides comparative transcriptome analyses of plants grown in both light and dark conditions within the same spaceflight. CARA compared three genotypes of Arabidopsis grown in ambient light and in the dark on board the International Space Station (ISS); Col-0, Ws, and phyD, a phytochrome D mutant in the Col-0 background.

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Media

Spotlight

3 min

One year after his pioneering flight aboard Blue Origin’s New Shepard rocket, University of Florida space biologist Rob Ferl, Ph.D., is still processing what it meant — not just for his career, but for science itself. “What stands out the most is just the overwhelming gratitude,” Ferl said. “It was such an amazing opportunity for a scientist to go to space and actually do science.” Ferl, a professor in UF’s Horticultural Sciences Department, Director of the Astraeus Space Institute, and Assistant Vice President of Research, became one of the first space biologists to fly alongside his own experiment — a moment that marked a new era in researcher-led missions. His suborbital journey provided a rare opportunity to study how terrestrial biology responds to the very first moments of spaceflight. “For decades, space biology has relied on professional astronauts to carry out experiments designed by scientists on Earth,” Ferl explained. “But to truly understand how biology works in space, I believe you as the scientist have to be there. You have to feel the environment.” This September, Ferl and longtime collaborator Anna-Lisa Paul, Ph.D., will be back at Blue Origin’s West Texas launch site, continuing their work with a new series of plant experiments. Ferl and Paul, who directs UF’s Interdisciplinary Center for Biotechnology Research and is a professor in Horticultural Sciences, are tracking fluorescently tagged genes in Arabidopsis plants to study how gene expression changes during the rapid shift from Earth’s gravity to the microgravity of spaceflight and back again. It’s a full-circle moment for Ferl, who remains deeply engaged in the same questions that sent him to space a year ago. Unpacking the Transition from Earth to Space Ferl’s experiment focused on the early metabolic responses of plants during the critical transition from Earth’s gravity to the weightlessness of space. “The scientific community has accumulated plenty of data comparing biology in orbit with that on Earth,” he said. “But we’ve known almost nothing about what happens in those first few minutes as organisms enter space and are exposed to microgravity.” Initial results from the flight reveal intense metabolic changes in the early moments of spaceflight. These changes are distinct from, but connected to, the long-term adaptations seen in orbit. Early Findings, Future Impact While the data from Ferl’s experiment are still on the way to being published, the findings are already shaping the direction of ongoing research. The work contributes to a growing understanding of how terrestrial life, from plants to humans, shares fundamental pathways in responding to the space environment. “This has real implications for the future of space missions,” Ferl noted. “As we send more people and more biology into space in support of exploration, we need a comprehensive understanding of how living systems adapt — right from the start.” Ferl and his team will return to Blue Origin’s launch site in Texas in September to continue their research, sending an uncrewed payload of plants into suborbital space. The flight carries no humans—but it does carry an automated experiment designed to advance their understanding of plant biology in space. It’s part of a broader effort to refine what Ferl calls “researcher-tended missions.” A New Course for UF Space Science The mission has not only shaped the trajectory of Ferl’s research, it has also energized Astraeus and the university’s space biology efforts. “This is about building a new kind of science culture,” Ferl said. “One where the scientists are embedded in every part of the mission, from experiment design to the moment of launch.” As the one-year anniversary of his flight approaches, Ferl remains focused on pushing the boundaries of what science in space can be. But he hasn’t forgotten the magnitude of the moment. “Even a year later,” he said, “the most powerful thing I feel is just: thank you. Thank you for the chance to go, to see it for myself, and to bring that knowledge back to Earth.”

Anna-Lisa PaulRob Ferl