Aysegul Gunduz operates the Brain Mapping Laboratory where she studies precursors to behavior and aftereffects of stimulation in neural networks to understand this interaction through electrophysiology and bioimaging. Her lab aims to translate this knowledge into clinical diagnostic and therapeutic systems to improve the quality of life of those suffering from neurological disorders. The lab works with neurosurgical patients with epilepsy and movement disorders (Tourette’s syndrome, Parkinson’s Disease, essential tremor), as well as stroke patients undergoing neurorehabilitation. The integration of behavioral neuroscience, clinical physiology and biosignal processing is prolific to the development of translational medicine applications, and our research agenda sits squarely at their nexus.
Areas of Expertise (8)
Deep Brain Stimulation
Media Appearances (1)
Abie Winner Aysegul Gunduz Promotes Diversity in Education
Anita B. Organization tv
“She is an inspiring mentor and a creative educator who has coached numerous students toward prestigious fellowships.” At the 2017 Grace Hopper Celebration (GHC 17), Dr. Aysegul Gunduz accepts the 2017 Emerging Leader Abie Award in Honor of Denice Denton.
Chronic embedded cortico-thalamic closed-loop deep brain stimulation for the treatment of essential tremorScience Translational Medicine
Deep brain stimulation (DBS) is an approved therapy for the treatment of medically refractory and severe movement disorders. However, most existing neurostimulators can only apply continuous stimulation [open-loop DBS (OL-DBS)], ignoring patient behavior and environmental factors, which consequently leads to an inefficient therapy, thus limiting the therapeutic window.
Pavlovian bias in Parkinson’s disease: an objective marker of impulsivity that modulates with deep brain stimulationNature Scientific Reports
Robert S. Eisinger, et. al
Impulsivity is a common symptom in Parkinson’s disease (PD). Adaptive behavior is influenced by prepotent action-reward and inaction-avoid loss Pavlovian biases. We aimed to assess the hypothesis that impulsivity in PD is associated with Pavlovian bias, and to assess whether dopaminergic medications and deep brain stimulation (DBS) influence Pavlovian bias. A PD DBS cohort (N = 37) completed a reward-based Go/No-Go task and bias measures were calculated.
Differentiating tic electrophysiology from voluntary movement in the human thalamocortical circuitJournal of Neurology, Neurosurgery, and Psychiatry
Jackson N. Cagle, et. al
Tourette syndrome is a neurodevelopmental disorder commonly associated with involuntary movements, or tics. We currently lack an ideal animal model for Tourette syndrome. In humans, clinical manifestation of tics cannot be captured via functional imaging due to motion artefacts and limited temporal resolution, and electrophysiological studies have been limited to the intraoperative environment.