Barry Setlow
Professor | University of Florida
Gainesville, FL, UNITED STATES
Barry Setlow focuses on understanding the neural and behavioral mechanisms of substance use disorders and aging.
Biography
Barry Setlow is a professor in the Department of Psychiatry in the College of Medicine, where he works with other UF investigators to conduct research on the neural and behavioral mechanisms of cognition, motivation and decision-making in the context of substance use disorders and aging.
Areas of Expertise (10)
Aging
Neuroscience
Impulsivity
Memory
Animal Models
Substance use
Addiction
Decision Making
Risk Taking
Cognition
Articles (3)
Pharmacokinetics of delta-9-tetrahydrocannabinol following acute cannabis smoke exposure in mice; effects of sex, age, and strain
Frontiers in PharmacologyEmely A. Gazarov, et. al
2023-08-28
Increased use of cannabis and cannabinoids for recreational and medical purposes has led to a growth in research on their effects in animal models. The majority of this work has employed cannabinoid injections; however, smoking remains the most common route of cannabis consumption. To better model real-world cannabis use, we exposed mice to cannabis smoke to establish the pharmacokinetics of Δ9THC and its metabolites in plasma and brain.
Age-Related Changes in Risky Decision Making and Associated Neural Circuitry in a Rat Model
eNeuroCaitlin A. Orsini, et. al
2023-01-01
Altered decision making at advanced ages can have a significant impact on an individual's quality of life and the ability to maintain personal independence. Relative to young adults, older adults make less impulsive and less risky choices; although these changes in decision making could be considered beneficial, they can also lead to choices with potentially negative consequences (e.g., avoidance of medical procedures).
Regulation of risky decision making by gonadal hormones in males and females
NeuropsychopharmacologyCaitlin A. Orsini, et. al
2020-09-12
Psychiatric diseases characterized by dysregulated risky decision making are differentially represented in males and females. The factors that govern such sex differences, however, remain poorly understood. Using a task in which rats make discrete trial choices between a small, "safe" food reward and a large food reward accompanied by varying probabilities of footshock punishment, we recently showed that females are more risk averse than males.
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