Bikash Sahay

Research Associate Professor University of Florida

Gainesville FL

Bikash Sahay's research focuses on gut microbiology and immunology.

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Biography

Bikash Sahay, a research associate professor at the University of Florida's College of Veterinary Medicine, specializes in gut microbiology, disease resistance mechanisms, and vaccine development. His extensive research portfolio includes significant contributions to understanding host-pathogen interactions, particularly with Borrelia burgdorferi, and the application of RNA interference in controlling viral infections. Sahay has developed innovative oral vaccines and explored the therapeutic potential of gut microbiota in treating inflammatory diseases. His work has been widely recognized, with numerous publications in high-impact journals and patents for novel therapeutic agents. Sahay's research is driven by a commitment to advancing veterinary and human medicine through innovative disease prevention and treatment approaches.

Areas of Expertise

Cancer

Infectious Diseases

Probiotic-Engineering and Application

Lyme Disease

Gut-Microbiota

Immunology

Social

Articles

A tryptophan-deficient diet induces gut microbiota dysbiosis and increases systemic inflammation in aged mice

International Journal of Molecular Sciences

Ibrahim Yusufu, et. al

2021-05-08

The gut microflora is a vital component of the gastrointestinal (GI) system that regulates local and systemic immunity, inflammatory response, the digestive system and overall health. Older people commonly suffer from inadequate nutrition or poor diets, which could potentially alter the gut microbiota. The essential amino acid (AA) tryptophan (TRP) is a vital diet component that plays a critical role in physiological stress responses, neuropsychiatric health, oxidative systems, inflammatory responses and GI health.

Canine osteosarcoma checkpoint expression correlates with metastasis and T-cell infiltrate.

Veterinary Immunology and Immunopathology

Matthew J Cascio, et. al

2020-12-15

Immune-targeted therapies are being successfully implemented into cancer clinical practice. In particular checkpoint inhibitors are employed to modulate the immune microenvironment of solid tumors. We sought to determine the expression of PD-L1, HVEM and B7H3 in human and canine osteosarcoma, and correlate expression with clinical features and tumor infiltrating lymphocytes in naturally-occurring canine osteosarcoma.

Analysis of canine myeloid-derived suppressor cells (MDSCs) utilizing fluorescence-activated cell sorting, RNA protection mediums to yield quality RNA for single-cell RNA sequencing.

Veterinary Immunology and Immunopathology

K Jackson, et. al

2020-11-07

Fluorescence-activated cell sorting (FACS) is a branch of flow cytometry that allows for the isolation of specific cell populations that can then be further analyzed by single-cell RNA sequencing (scRNA-seq). When utilizing FACS for population isolation prior to sequencing, it is essential to consider the protection of RNA from RNase activity, environmental conditions and the sorting efficiency to ensure optimum sample quality.