Bikash Sahay
Research Associate Professor | University of Florida
Gainesville, FL, UNITED STATES
Bikash Sahay works on the interaction of Borreliella burgdorferi with its host and the beneficial use of gut microbes-derived products.
Biography
Bikash Sahay's research focuses on identifying and using microbes or their products to treat human ailments, including those with infectious origins. Although it is largely unexplored and under appreciated, gut microbiota plays a critical role in health and disease states. The human gastrointestinal (G.I.) tract harbors a complex consortium of trillions of microbes, thousands of bacterial phylotypes, methanogenic archaea and fungi colonizing the entire gut length, collectively referred to as the microbiota, which produces 100-fold many gene products as the host. Lyme disease is caused by a spirochete and could cause long-lasting inflammation in the host. Bikash's research attempts to identify the molecular mechanism of the persistence of its ever-lasting symptoms.
Areas of Expertise (3)
Gut-Microbiota
Lyme Disease
Probiotic-Engineering and Application
Articles (3)
A tryptophan-deficient diet induces gut microbiota dysbiosis and increases systemic inflammation in aged mice
International Journal of Molecular SciencesIbrahim Yusufu, et. al
2021-05-08
The gut microflora is a vital component of the gastrointestinal (GI) system that regulates local and systemic immunity, inflammatory response, the digestive system and overall health. Older people commonly suffer from inadequate nutrition or poor diets, which could potentially alter the gut microbiota. The essential amino acid (AA) tryptophan (TRP) is a vital diet component that plays a critical role in physiological stress responses, neuropsychiatric health, oxidative systems, inflammatory responses and GI health.
Canine osteosarcoma checkpoint expression correlates with metastasis and T-cell infiltrate.
Veterinary Immunology and ImmunopathologyMatthew J Cascio, et. al
2020-12-15
Immune-targeted therapies are being successfully implemented into cancer clinical practice. In particular checkpoint inhibitors are employed to modulate the immune microenvironment of solid tumors. We sought to determine the expression of PD-L1, HVEM and B7H3 in human and canine osteosarcoma, and correlate expression with clinical features and tumor infiltrating lymphocytes in naturally-occurring canine osteosarcoma.
Analysis of canine myeloid-derived suppressor cells (MDSCs) utilizing fluorescence-activated cell sorting, RNA protection mediums to yield quality RNA for single-cell RNA sequencing.
Veterinary Immunology and ImmunopathologyK Jackson, et. al
2020-11-07
Fluorescence-activated cell sorting (FACS) is a branch of flow cytometry that allows for the isolation of specific cell populations that can then be further analyzed by single-cell RNA sequencing (scRNA-seq). When utilizing FACS for population isolation prior to sequencing, it is essential to consider the protection of RNA from RNase activity, environmental conditions and the sorting efficiency to ensure optimum sample quality.
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