Brent Reynolds
Professor | University of Florida
Gainesville, FL, UNITED STATES
Brent Reynolds has been working with regenerative medicine for more than 30 years, with a focus on neural and cancer stem cells.
Biography
Brent Reynolds helped discover the existence of a stem cell in the adult central nervous system, challenging a century-old dogma that the adult brain was unable to produce new neurons. Brent holds 16 U.S. patents related to neural stem cells and his lab is currently focused on the development of stem cell-specific assays, in situ manipulation of neural stem cells and understanding the role that solid tissue cancer stem cells play in tumor initiation and metastasis.
Areas of Expertise (5)
Cell Replacement Strategies
Neural Stem Cells
Cancer Stem Cells
Cannabinoids
Traditional Chinese Medicine
Articles (3)
Slow-Cycling Cells in Glioblastoma: A Specific Population in the Cellular Mosaic of Cancer Stem Cells
CancersBrent A. Reynolds, et al.
2022-02-23
Glioblastoma exhibits populations of cells that drive tumorigenesis, treatment resistance and disease progression. Cells like this have been described to express specific surface and intracellular markers. In glioblastoma, each of these cellular fractions was shown to harbor cardinal features of cancer stem cells. The researchers focus on the comparison of these cells and present evidence of great phenotypic and functional heterogeneity in brain cancer cell populations with stemness properties.
Method for Isolating Extracellular Vesicles from Human Neural Stem Cells Expanded Under Neurosphere Culture
Neural Progenitor CellsBrent A. Reynolds, et al.
2021-09-24
Neural stem cells transplantation enhances plasticity and restores functions in neurological diseases. Therapeutic benefits of neural stem cells are due to their ability to replace the lost neurons and glial cells and also secreting a wide array of free and membrane-bound bioactive molecules that can reduce the hostility of diseased microenvironment, resolve inflammation and rescue damaged neural cells.
Eco-oncology: Applying ecological principles to understand and manage cancer
Ecology and EvolutionBrent A. Reynolds, et al.
2020-07-29
The similarities between initiation and growth of tumors and dynamics of biological populations and between invasion and community dynamics suggest oncology can benefit from an ecological perspective to improve understanding of cancer biology. Researchers argue an eco-evolutionary perspective is essential to this understanding by ecologically informed therapeutic approaches by combining standard of care treatments with strategies aimed at decreasing the evolutionary potential and fitness of neoplastic cells.
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