Dalen Agnew
Department Chair, Pathology and Diagnostic Investigation Michigan State University
- East Lansing MI
Dalen Agnew studies reproductive pathology of free-ranging and captive wildlife, zoo animal health, international collaboration in medicine
Biography
The purpose of his lab's research is to understand and document the reproductive pathology of free-ranging and captive wildlife, particularly when contracepted pharmacologically, hormonally, or by husbandry and management. Particular species of interest include: Elephants, polar bears, large carnivores, and amphibians. The lab also seeks to develop pathology tools and protocols that can be used throughout the world, particularly in the developing world to enhance conservation and food safety.
His lab’s recent investigations include reproductive lesions of captive suids, ovarian carcinoma in jaguars, and reproductive lesions in polar bears.
Industry Expertise
Areas of Expertise
Accomplishments
2021 Distinguished Partnership Award for Community-Engaged Research
2021-02-24
Agnew and his collaborator team at Potter Park Zoo were presented with the 2021 Distinguished Partnership Award for Community-Engaged Research for their project “A Half-Century of Collaboration in Animal Health Education, Research, and Outreach.”
Education
University of California, Davis
PhD
2006
Michigan State University
DVM
1990
Journal Articles
Endocrine Diagnostics: Principles and Applications
Veterinary Clinics: Exotic Animal PracticeBrian K. Petroff, Ronan Eustace, Kimberly A. Thompson, Corinne Kozlowski, Dalen Agnew
2024-10-15
Endocrine testing depends on the technical ability to measure low and high diagnostic hormone concentrations.
Integrins mediate placental extracellular vesicle trafficking to lung and liver in vivo
Scientific ReportsSean L. Nguyen, Soo Hyun Ahn, Jacob W. Greenberg, Benjamin W. Collaer, Dalen W. Agnew, Ripla Arora & Margaret G. Petroff
2021-02-18
Membrane-bound extracellular vesicles (EVs) mediate intercellular communication in all organisms, and those produced by placental mammals have become increasingly recognized as significant mediators of fetal-maternal communication. Here, we aimed to identify maternal cells targeted by placental EVs and elucidate the mechanisms by which they traffic to these cells. Exogenously administered pregnancy-associated EVs traffic specifically to the lung; further, placental EVs associate with lung interstitial macrophages and liver Kupffer cells in an integrin-dependent manner. Localization of EV to maternal lungs was confirmed in unmanipulated pregnancy using a transgenic reporter mouse model, which also provided in situ and in vitro evidence that fetally-derived EVs, rarely, may cause genetic alteration of maternal cells. These results provide for the first time direct in vivo evidence that placental EVs target maternal immune cells, and further, that EVs can alter cellular phenotype.
Super-resolution and segmentation deep learning for breast cancer histopathology image analysis
Biomedical Optics ExpressAniwat Juhong, Bo Li, Cheng-You Yao, Chia-Wei Yang, Dalen W. Agnew, Yu Leo Lei, Xuefei Huang, Wibool Piyawattanametha, and Zhen Qiu
2022-12-05
Traditionally, a high-performance microscope with a large numerical aperture is required to acquire high-resolution images. However, the images’ size is typically tremendous. Therefore, they are not conveniently managed and transferred across a computer network or stored in a limited computer storage system. As a result, image compression is commonly used to reduce image size resulting in poor image resolution.
