David Fuller directs a research laboratory in the McKnight Brain Institute. David's laboratory is focused on developing new treatments for conditions such as Pompe disease and spinal cord injury.
Areas of Expertise (7)
Spinal Cord Injury
Locomotor-respiratory coupling in ambulatory adults with incomplete spinal cord injury.Spinal cord series and cases
Tommy W. Sutor
After incomplete spinal cord injury (iSCI), propriospinal pathways may remain intact enabling coupling between respiration and locomotion. This locomotor-respiratory coupling (LRC) may enable coordination between these two important behaviors and have implications for rehabilitation after iSCI. However, coordination between these behaviors is not well understood and it is unknown if iSCI disrupts LRC.
Feasibility of transcutaneous spinal direct current stimulation combined with locomotor training after spinal cord injury.Spinal cord
Kelly A. Hawkins, et. al
To investigate the feasibility of a novel combinatorial approach with simultaneous delivery of transcutaneous spinal direct current stimulation (tsDCS) and locomotor training (tsDCS + LT) after spinal cord injury, compared to sham stimulation and locomotor training (sham + LT) and examine preliminary effects on walking function. Eight individuals with chronic incomplete spinal cord injury (ISCI) completed the two-part protocol.
Hyperbaric Oxygen Therapy after Mid-Cervical Spinal Contusion Injury.Journal of neurotrauma
Sara M.F. Turner, et. al
Hyperbaric oxygen (HBO) therapy is frequently used to treat peripheral wounds or decompression sickness. Evidence suggests that HBO therapy can provide neuroprotection and has an anti-inflammatory impact after neurological injury, including spinal cord injury (SCI). Our primary purpose was to conduct a genome-wide screening of mRNA expression changes in the injured spinal cord after HBO therapy.
Enhancing Locomotor Learning With Transcutaneous Spinal Electrical Stimulation and Somatosensory Augmentation: A Pilot Randomized Controlled Trial in Older Adults.Frontiers in aging neuroscience
David J. Clark, et. al
This study investigated locomotor learning of a complex terrain walking task in older adults, when combined with two adjuvant interventions: transcutaneous spinal direct current stimulation (tsDCS) to increase lumbar spinal cord excitability and textured shoe insoles to increase somatosensory feedback to the spinal cord. The spinal cord has a crucial contribution to control of walking, and is a novel therapeutic target for rehabilitation of older adults.