David B. Peden, MD, MS is Professor of Pediatrics, Medicine and Microbiology/Immunology and Toxicology; Chief, Division of Pediatric Allergy, Immunology, Rheumatology and Infectious Diseases in the Department of Pediatrics and an expert in air pollution and asthma, airway inflammation, allergic diseases.
Areas of Expertise (8)
Pediatric Allergy and Immunology
Allergy and Immunology
West Virginia University: MD, Medicine 1984
West Virginia University: Residency, Pediatrics 1987
National Institutes of Health: Fellowship, Allergy/Immunology 1992
- Professor, Department of Microbiology and Immunology
- Division Chief, Pediatric Allergy, Immunology and Rheumatology
- Director, Center for Environmental Medicine, Asthma and Lung Biology
The role of oxidative stress and innate immunity in O3 and endotoxin‐induced human allergic airway diseaseImmunological Reviews
David B. Peden
Ozone (O3) and endotoxin are common environmental contaminants that cause asthma exacerbation. These pollutants have similar phenotype response characteristics, including induction of neutrophilic inflammation, changes in airway macrophage immunophenotypes, and ability to enhance response to inhaled allergen. Evoked phenotyping studies of volunteers exposed to O3 and endotoxin were used to identify the response characteristics of volunteers to these pollutants. New studies support the hypotheses that similar innate immune and oxidant processes modulate response to these agents. These include TLR4 and inflammasome‐mediated signaling and cytokine production. Innate immune responses are also impacted by oxidative stress. It is likely that continued discovery of common molecular processes which modulate response to these pollutants will occur. Understanding the pathways that modulate response to pollutants will also allow for discovery of genetic and epigenetic factors that regulate response to these pollutants and determine risk of disease exacerbation. Additionally, defining the mechanisms of response will allow rational selection of interventions to examine. Interventions focused on inhibition of Toll‐like receptor 4 and inflammasome represent promising new approaches to preventing pollutant‐induced asthma exacerbations. Such interventions include specific inhibitors of innate immunity and antioxidant therapies designed to counter the effects of pollutants on cell signaling.