Dr Cathy Slack joined the School of Life & Health Sciences in August 2016 as a Lecturer in Biosciences, after conducting postdoctoral research with Dame Prof. Linda Partridge (Institute of Healthy Ageing, University College London) and Prof. William Chia (MRC Centre for Developmental Neurobiology, Kings College London). Her research background covers ageing biology, cell signalling and Drosophila genetics.
Cathy's current research aims to understand the molecular and cellular mechanisms that govern how an animal ages using the fruit fly, Drosophila melanogaster, as a model system. Current key research topics of interest include: understanding the regulatory networks that control the activity of key proteins within the insulin signalling pathway; exploring the role of energy balance and metabolism in regulating lifespan; and developing pharmacological interventions that extend lifespan and improve life-long health.
Areas of Expertise (5)
Biological Mechanisms of Ageing
Imperial College London: PhD, Genetics 2002
University of Southampton: BSc, Biological Sciences 1998
- Higher Eduation Academy (FHEA) : Fellow
- Biochemical Society : Member
- British Society for Research on Ageing (BSRA) : Member
- Higher Eduation Academy (SFHEA) : Senior Fellow
- British Society for Research on Ageing (BSRA) : Secretary
Media Appearances (1)
Biological vs chronological age: how old are you really?
The Conversation online
Researchers are developing tests to calculate your true biological age. They claim that such tests can measure how well your body is coping with the rigours of life. But how accurate are these tests and could they somehow be used to predict your future health?
Expression and purification of recombinant G protein-coupled receptors: A reviewProtein Expression and Purification
2020 Given their extensive role in cell signalling, GPCRs are significant drug targets; despite this, many of these receptors have limited or no available prophylaxis. Novel drug design and discovery significantly rely on structure determination, of which GPCRs are typically elusive. Progress has been made thus far to produce sufficient quantity and quality of protein for downstream analysis.
Zoledronate extends healthspan and survival via the mevalonate pathway in a FOXO-dependent mannerbioRxiv
2020 Increased longevity has not been paralleled by extended healthspan, resulting in more years spent with multiple diseases in older age. As such, interventions to improve healthspan are urgently required. Zoledronate is a nitrogen containing bisphosphonate, which inhibits the farnesyl pyrophosphate synthase (FPPS) enzyme, central to the mevalonate pathway.
To help aging populations, classify organismal senescenceScience
2019 Globally, citizens exist for sustained periods in states of aging-related disease and multimorbidity. Given the urgent and unmet clinical, health care, workforce, and economic needs of aging populations, we need interventions and programs that regenerate tissues and organs and prevent and reverse aging-related damage, disease, and frailty (1). In response to these challenges, the World Health Organization (WHO) has called for a comprehensive public-health response within an international legal framework based on human rights law.
Signal Transduction Pathways in AgeingBiochemistry and Cell Biology of Ageing: Part I Biomedical Science
2019 It is now widely recognised that ageing and its associated functional decline are regulated by a wide range of molecules that fit into specific cellular pathways. Here, we describe several of the evolutionary conserved cellular signalling pathways that govern organismal ageing and discuss how their identification, and work on the individual molecules that contribute to them, has aided in the design of therapeutic strategies to alleviate the adverse effects of ageing and age-related disease.
Ras signaling in aging and metabolic regulationNutrition and Healthy Aging
2017 Aberrant signal transduction downstream of the Ras GTPase has a well-established role in tumorigenesis. Mutations that result in hyperactivation of Ras are responsible for a third of all human cancers. Hence, small molecule inhibitors of the Ras signal transduction cascade have been under intense focus as potential cancer treatments. In both invertebrate and mammalian models, emerging evidence has also implicated components of the Ras signaling pathway in aging and metabolic regulation.