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Dr. Mojgan Hodaie - University Health Network. Toronto, ON, CA

Dr. Mojgan Hodaie Dr. Mojgan Hodaie

Staff Neurosurgeon at the Toronto Western Hospital | University Health Network

Toronto, ON, CANADA

Dr. Mojgan Hodaie is an associate professor of surgery at the University of Toronto and a scientist at Krembil Research Institute (Krembil).

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An Inside Look: Gamma Knife Treatment for Brain Tumours

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Biography

Dr. Hodaie completed her Neurosurgery residency and fellowship in Stereotactic and Functional Neurosurgery at the University of Toronto. Her field of clinical expertise and research interest include neuromodulation for the treatment of movement disorders and pain, surgical treatment of trigeminal neuralgia and Gamma Knife radiosurgery. She is currently an Associate Professor of Surgery, surgical co-director of the Joey and Toby Tanenbaum Gamma Knife Radiosurgery unit at the Toronto Western Hospital and associate member, Institute of Medical Science, Faculty of Medicine.

She has an active research lab focusing on the role of structural MRI techniques such as cortical thickness analysis and diffusion tensor imaging/tractography. Current lab projects explore methods in which these imaging techniques can pinpoint key neuroanatomical signatures in different pain syndromes, and their utility as imaging adjuncts in surgical diagnosis and treatment. Dr. Hodaie also has a strong interest in international neuroscience and neurosurgical education. She has pioneered and enlisted international collaboration in the application of new educational tools in the field of neurosurgical education in the developing world, focusing on structured online course modules in neurosurgery.

Industry Expertise (5)

Education/Learning Health Care - Providers Research Writing and Editing Health and Wellness

Areas of Expertise (7)

Neuroscience Neurosurgery Medicine Surgery Neuroimaging MRI Pain Management

Accomplishments (1)

Bernard Langer Surgeon Scientist (2013) (professional)

Dr. Hodaie was granted the Bernard Langer Surgeon Scientist award by the Faculty of Medicine at the University of Toronto and the Division of Neurosurgery Alan Hudson Faculty teaching award for 2013.

Education (2)

University of Toronto: Residency and Fellowship, Stereotactic and Functional Neurosurgery

Queen’s University: Ph.D., Medicine

Affiliations (2)

  • The Gamma Knife Radiosurgery Unit at the Toronto Western Hospital : Surgical Co-Director
  • Hodaie Lab : Principal Investigator

Media Appearances (3)

The UpBeat: Comedy Night for Parkinson's among things behind a grandfather's 'miracle'

Ottawa Citizen  online

2015-01-09

"After recent brain stimulation surgery, Herb Durand received the best Christmas present ever — being able to hold his grandson, Warren."

Dr. Hodaie is featured in this article by the Ottawa Citizen.

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Stroke patient to run in Scotiabank Toronto Waterfront Marathon

The Toronto Star  online

2013-10-17

"Dina Pestonji, 29, to run half marathon this weekend after suffering a stroke 10 months ago."

Dr. Hodaie is featured in this article by the Toronto Star.

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A 'Star Trekky' procedure nobody knows about

The Globe and Mail  online

Dr. Hodaie is featured in this article about the Gamma Knife.

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Event Appearances (1)

Neuroimaging: Pain and Psychiatry

American Society for Stereotactic and Functional Neurosurgery 2016 Biennial Meeting  Chicago, IL

2016-06-20

Articles (3)

Sequence of electrode implantation and outcome of deep brain stimulation for Parkinson's disease Pain

9 September 2015

Introduction: The effect of the variability of electrode placement on outcomes after bilateral deep brain stimulation of subthalamic nucleus has not been sufficiently studied, especially with respect to the sequence of hemisphere implantation.

Methodology: We retrospectively analysed the clinical and radiographic data of all the consecutive patients with Parkinson's disease who underwent surgery at our centre and completed at least 1 year follow-up. The dispersion in electrode location was calculated by the square of deviation from population mean, and the direction of deviation was analysed by comparing the intended and final implantation coordinates. Linear regression analysis was performed to analyse the predictors of postoperative improvement of the motor condition, also controlling for the sequence of implanted hemisphere.

Results: 76 patients (mean age 58±7.2 years) were studied. Compared with the first side, the second side electrode tip had significantly higher dispersion as an overall effect (5.6±21.6 vs 2.2±4.9 mm2, p=0.04), or along the X-axis (4.1±15.6 vs 1.4±2.4 mm2, p=0.03) and Z-axis (4.9±11.5 vs 2.9±3.6 mm2, p=0.02); the second side stimulation was also associated with a lower threshold for side effects (contact 0, p

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Long-term neuropsychiatric outcomes after pallidal stimulation in primary and secondary dystonia Neurology

4 August 2015

Objective: To evaluate changes in the diagnosis of Axis I psychiatric disorders in patients with primary and secondary dystonia after deep brain stimulation (DBS) of the globus pallidus internus (GPi).

Methods: Structured Clinical Interviews for the DSM-IV, Axis I psychiatric disorders, were prospectively performed before and after surgery. Diagnoses were made based on DSM-IV criteria. Psychiatric disorders were grouped into 5 categories: mood, anxiety, addiction, obsessive-compulsive disorders, and psychosis. Patients could be stratified to more than one category. Rates for unchanged diagnoses, diagnoses in remission, and new-onset diagnoses after surgery for each category were calculated.

Results: Fifty-seven patients with primary and secondary dystonia were included. Mean ± SD age at surgery and dystonia duration at time of surgery was 50.6 ± 13.8 and 19.0 ± 13.2 years, respectively. Preoperatively, 37 Axis I diagnoses were made in 25 patients, 43.8% of those presenting with at least 1 Axis I diagnosis (mostly mood and anxiety disorders). Mean ± SD duration of psychiatric follow-up was 24.4 ± 19.6 months. Overall, after surgery no significant changes (p = 0.16) were found in Axis I diagnoses (23 patients, 40.3%): 27 (73%) unchanged, 10 (27%) in complete remission, and 4 (12.9%) new-onset diagnoses.

Conclusions: Our results support the overall psychiatric stability of patients with primary and secondary dystonia treated with GPi DBS. However, considering the high psychiatric morbidity in the dystonia population, psychiatric assessments before and after surgery are strongly recommended.

Classification of evidence: This study provides Class IV evidence that GPi DBS does not change Axis I psychiatric diagnoses in patients with primary and secondary dystonia.

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Subcallosal Cingulate Connectivity in Anorexia Nervosa Patients Differs From Healthy Controls: A Multi-tensor Tractography Study Brain Stimulation

20 May 2015

Background: Anorexia nervosa is characterized by extreme low body weight and alterations in affective processing. The subcallosal cingulate regulates affect through wide-spread white matter connections and is implicated in the pathophysiology of anorexia nervosa.

Objectives: We examined whether those with treatment refractory anorexia nervosa undergoing deep brain stimulation (DBS) of the subcallosal white matter (SCC) show: 1) altered anatomical SCC connectivity compared to healthy controls, 2) white matter microstructural changes, and 3) microstructural changes associated with clinically-measured affect.

Methods: Diffusion magnetic resonance imaging (dMRI) and deterministic multi-tensor tractography were used to compare anatomical connectivity and microstructure in SCC-associated white matter tracts. Eight women with treatment-refractory anorexia nervosa were compared to 8 age- and sex-matched healthy controls. Anorexia nervosa patients also completed affect-related clinical assessments presurgically and 12 months post-surgery.

Results: 1) Higher (e.g. left parieto-occipital cortices) and lower (e.g. thalamus) connectivity in those with anorexia nervosa compared to controls. 2) Decreases in fractional anisotropy, and alterations in axial and radial diffusivities, in the left fornix crus, anterior limb of the internal capsule (ALIC), right anterior cingulum and left inferior fronto-occipital fasciculus. 3) Correlations between dMRI metrics and clinical assessments, such as low pre-surgical left fornix and right ALIC fractional anisotropy being related to post-DBS improvements in quality-of-life and depressive symptoms, respectively.

Conclusions: We identified widely-distributed differences in SCC connectivity in anorexia nervosa patients consistent with heterogenous clinical disruptions, although these results should be considered with caution given the low number of subjects. Future studies should further explore the use of affect-related connectivity and behavioral assessments to assist with DBS target selection and treatment outcome.

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