Areas of Expertise (8)
Epidemiology of Cadiovascular Disease
World Hypertension League Recognition of Excellence Award in Dietary Salt Reduction
40th Anniversary Gold Medal of the Lithuanian Society of Cardiology
2005 40th Anniversary Gold Medal of the Lithuanian Society of Cardiology
RCGP and Boots The Chemists Research Paper of the Year Award
2003 2002 RCGP and Boots The Chemists Research Paper of the Year Award (Royal College of General Practitioners)
I.S.H.I.B. Distinguished Researcher Award for 2003
2003 I.S.H.I.B. Distinguished Researcher Award for 2003 (International Society of Hypertension in Blacks)
University of Warwick: DSc, Medicine 2012
University of London: M.Sc., Epidemiology 1993
University of Naples: M.D. 1984
University Naples: B.S. 1981
- Association of Physicians of Great Britain & Ireland
- British and Irish Hypertension Society
- British Sleep Society
- National Heart Forum NHF
- European Society of Hypertension
- World Health Organization
- European Society of Cardiology
- American Heart Association
- Immediate Past President of the BIHS (2017-19)
Selected Media Appearances (5)
Revised NICE advice on hypertension a 'missed opportunity'
GP Online online
BIHS president Professor Francesco P Cappuccio, professor of cardiovascular medicine at the University of Warwick, said: 'The new NICE guideline is directed to the management of adults with hypertension, with or without diabetes, but excludes patients with established CVD (like prior myocardial infarction, stroke and heart failure).
Failure of industry-led salt reduction policy led to increase CVD deaths, study claims
However, a number of experts highlighted the limitations of the research. Francesco Cappuccio, Cephalon professor of cardiovascular medicine & epidemiology at the University of Warwick said, "The data cannot imply causality as they are not prospective recordings in the same individuals and not all potential confounders could be considered"...
Falls are more likely when you've had a bad night sleep
Science Daily online
Prof Francesco Cappuccio, Head of the Sleep, Health & Society programme at the University of Warwick's medical school, explains:
"The results obtained in healthy normal volunteers are surprising, given the ability at younger ages to compensate for such acute and short-lived sleep disruptions. We would expect more dramatic effects when these experiments be replicated in older people, whose vulnerability to sleep disruption, postural hypotension and risk of falls is much greater"...
Is a low-salt diet as unhealthy as having too much?
BBC Future online
Long-term, randomised trials comparing people who eat a lot versus a little salt could establish cause and effect. But very few such studies exist because of the funding requirements and ethical implications. “Randomised trials showing salt’s effect on the body are almost impossible to carry out,” says Francesco Cappuccio, professor of cardiovascular medicine and epidemiology at the University of Warwick’s medical school and author of the eight-year review...
Sleep deprivation: Late nights can lead to higher risk of strokes and heart attacks, study finds
Science Daily online
Professor Francesco Cappuccio from the University of Warwick Medical School, explained: "If you sleep less than six hours per night and have disturbed sleep you stand a 48 per cent greater chance of developing or dying from heart disease and a 15 per cent greater chance of developing or dying of a stroke.
"The trend for late nights and early mornings is actually a ticking time bomb for our health so you need to act now to reduce your risk of developing these life-threatening conditions."
Professor Cappuccio and co-author Dr Michelle Miller, from the University of Warwick, conducted the research programme which followed up evidence from seven to 25 years from more than 470,000 participants from eight countries including Japan, USA, Sweden and UK.
Professor Cappuccio explained: "There is an expectation in today's society to fit more into our lives. The whole work/life balance struggle is causing too many of us to trade in precious sleeping time to ensure we complete all the jobs we believe are expected of us"...
Selected Articles (6)
Improved and durable control of hypertension is a global priority for healthcare providers and policymakers. There are several lifestyle measures that are proven to result in improved blood pressure (BP) control. Moreover, there is incontrovertible evidence from large scale randomised controlled trials (RCTs) that antihypertensive drugs lower BP safely and effectively in the long-term resulting in substantial reduction in cardiovascular morbidity and mortality. Importantly, however, evidence is accumulating to suggest that patients neither sustain long-term healthy behaviours nor adhere to lifelong drug treatment regimens and thus alternative measures to control hypertension warrant further investigation. Endovascular renal denervation (RDN) appears to hold some promise as a non-pharmacological approach to lowering BP and achieves renal sympathectomy using either radiofrequency energy or ultrasound-based approaches. This treatment modality has been evaluated in clinical trials in humans since 2009 but initial studies were compromised by being non-randomised, without sham control and small in size. Subsequently, clinical trial design and rigour of execution has been greatly improved resulting in recent sham-controlled RCTs that demonstrate short-term reduction in ambulatory BP without any significant safety concerns in both medication-naïve and medication-treated hypertensive patients. Despite this, the joint UK societies still feel that further evaluation of this therapy is warranted and that RDN should not be offered to patients outside of the context of clinical trials. This document reviews the updated evidence since our last consensus statement from 2014 and provides a research agenda for future clinical studies.
The International Consortium for Quality Research on Dietary Sodium/Salt (TRUE) is a coalition of intentional and national health and scientific organizations formed because of concerns low‐quality research methods were creating controversy regarding dietary salt reduction. One of the main sources of controversy is believed related to errors in estimating sodium intake with urine studies. The recommendations and positions in this manuscript were generated following a series of systematic reviews and analyses by experts in hypertension, nutrition, statistics, and dietary sodium. To assess the population's current 24‐hour dietary sodium ingestion, single complete 24‐hour urine samples, collected over a series of days from a representative population sample, were recommended. To accurately estimate usual dietary sodium at the individual level, at least 3 non‐consecutive complete 24‐hour urine collections obtained over a series of days that reflect the usual short‐term variations in dietary pattern were recommended. Multiple 24‐hour urine collections over several years were recommended to estimate an individual's usual long‐term sodium intake. The role of single spot or short duration timed urine collections in assessing population average sodium intake requires more research. Single or multiple spot or short duration timed urine collections are not recommended for assessing an individual's sodium intake especially in relationship to health outcomes. The recommendations should be applied by scientific review committees, granting agencies, editors and journal reviewers, investigators, policymakers, and those developing and creating dietary sodium recommendations. Low‐quality research on dietary sodium/salt should not be funded, conducted, or published.
Dysfunction in 24-h circadian rhythms is a common occurrence in ageing adults; however, circadian rhythm disruptions are more severe in people with age-related neurodegenerative diseases, including Alzheimer's disease and related dementias, and Parkinson's disease. Manifestations of circadian rhythm disruptions differ according to the type and severity of neurodegenerative disease and, for some patients, occur before the onset of typical clinical symptoms of neurodegeneration. Evidence from preliminary studies suggest that circadian rhythm disruptions, in addition to being a symptom of neurodegeneration, might also be a potential risk factor for developing Alzheimer's disease and related dementias, and Parkinson's disease, although large, longitudinal studies are needed to confirm this relationship. The mechanistic link between circadian rhythms and neurodegeneration is still not fully understood, although proposed underlying pathways include alterations of protein homoeostasis and immune and inflammatory function. While preliminary clinical studies are promising, more studies of circadian rhythm disruptions and its mechanisms are required. Furthermore, clinical trials are needed to determine whether circadian interventions could prevent or delay the onset of neurodegenerative diseases.
The publication in the last few years of a number of prospective observational studies suggesting a J-shaped association between levels of salt (sodium) consumption and cardiovascular outcomes has opened a debate on the pertinence of population-wide salt reduction policies to reduce cardiovascular disease burden, and some have even questioned the global World Health Organization guidelines, that recommend a 30% reduction in salt consumption by 2025, aiming at an ideal target of no more than 5 g of salt consumption per day.
Acute sleep deprivation is known to affect human balance and posture control. However, the effects of variations in sleep quality and pattern over consecutive days have received less attention. This study investigated the associations between day-to-day variations in sleep quality and standing balance in healthy subjects. Twenty volunteers (12 females and 8 males; age: 28.8±5.7 years, body mass index: 23.4±3.4 kg/m 2, resting heart rate: 63.1±8.7 bpm) with no history of sleep disorders or balance impairments participated in the study. Sleep and balance were assessed over two consecutive days. Sleep quality variations were assessed using sleep diary, actigraphy and heart rate variability (HRV) measures. Sleep was monitored at home, using an unobtrusive wearable device. Balance was assessed in a gait lab using foot centre of pressure (COP) displacement during quiet standing.
To assess the prospective relationship between sleep and obesity in a paediatric population.