hero image
Genane Loheswaran, Msc, PhD - VieLight. Toronto, ON, CA

Genane Loheswaran, Msc, PhD Genane Loheswaran, Msc, PhD

Research Manager | VieLight

Toronto, ON, CANADA

Dr. Loheswaran has 10 years of experience in research including, protocol design, trial management, and statistics/data analysis

Social

Areas of Expertise (6)

Experimental Design Data Analysis Neuroscience Research Immunohistochemistry Molecular Biology

Accomplishments (5)

School of Graduate Studies Research Travel Grant

2014

Pharmacology Book Fund Travel Award

2014

University of Toronto Graduate Fellowship

2012 - 2013

Ontario Graduate Scholarship

2011 - 2012

Canadian Institute of Health Research Strategic Training Grant in Public Health Policy

2010 - 2011

Education (3)

University of Toronto: Ph.D., Pharmacology 2016

McMaster University: M.Sc., Neuroscience 2010

University of Toronto: B.Sc., Neuroscience 2008

Articles (5)

Alcohol Impairs N100 Response to Dorsolateral Prefrontal Cortex Stimulation. Scientific Reports

Loheswaran, G., Barr, M.S., Rajji, T.K., Zomorrodi, R., Le Foll, B., Daskalakis, Z.J.

2017

Impairment of Neuroplasticity in the Dorsolateral Prefrontal Cortex by Alcohol Scientific Reports

Loheswaran, G., Barr, M.S., Rajji, T.K., Zomorrodi, R., Le Foll, B., Daskalakis, Z.J.

2017

Previous studies have demonstrated that alcohol consumption impairs neuroplasticity in the motor cortex. However, it is unknown whether alcohol produces a similar impairment of neuroplasticity in the dorsolateral prefrontal cortex (DLPFC), a brain region that plays an important role in cognitive functioning. The aim of the current study was to evaluate the effect of alcohol intoxication on neuroplasticity in the DLPFC. Paired associative stimulation (PAS) combined with electroencephalography (EEG) was used for the induction and measurement of associative LTP-like neuroplasticity in the DLPFC. Fifteen healthy subjects were administered PAS to the DLPFC following consumption of an alcohol (1.5 g/l of body water) or placebo beverage in a within-subject cross-over design. PAS induced neuroplasticity was indexed up to 60 minutes following PAS. Additionally, the effect of alcohol on PAS-induced potentiation of theta-gamma coupling (an index associated with learning and memory) was examined prior to and following PAS. Alcohol consumption resulted in a significant impairment of mean (t = 2.456, df = 13, p = 0.029) and maximum potentiation (t = -2.945, df = 13, p = 0.011) compared to the placebo beverage in the DLPFC and globally. Alcohol also suppressed the potentiation of theta-gamma coupling by PAS. Findings from the present study provide a potential neurophysiological mechanism for impairment of cognitive functioning by alcohol.

view more

Brain Stimulation in Alcohol Use Disorders: Investigational and Therapeutic Tools. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

Loheswaran, G., Barr, M.S., Rajji, T.K., Zomorrodi, R., Le Foll, B., Daskalakis, Z.J.

2016

Alcohol use disorders (AUDs) are a major health and social problem worldwide. Brain stimulation holds great promise as an investigational tool to help us understand the pathophysiology of alcohol dependence and as a therapeutic tool to treat AUDs. Numerous studies suggest that glutamatergic, gamma-aminobutyric acidergic, and dopaminergic neurotransmission are altered by alcohol consumption and among patients with AUDs. Alcohol’s disruption of neurotransmission is likely to play an important role in its detrimental effects on neuroplasticity, which, in turn, may contribute to the pathophysiology of alcohol dependence. Specifically, aberrant neuroplasticity in the brain reward circuitry is a potential mechanism underlying the pathophysiology of alcohol dependence. The dorsolateral prefrontal cortex (DLPFC), a part of the brain’s reward circuitry, is directly accessible to noninvasive brain stimulation and may represent a potential target for the treatment of AUDs. While the literature suggests that impairments in neuroplasticity are likely to be present in the DLPFC and brain reward circuitry in alcohol-dependent patients, this is yet to be directly evaluated in humans. Findings from numerous neuromodulatory brain stimulation studies demonstrate that altering neuroplasticity in the DLPFC in alcohol-dependent patients holds promise as a treatment for alcohol dependence, but the optimal neuromodulatory parameters are yet to be identified. Gaining a better understanding of alcohol dependence vis à vis neuroplasticity in the DLPFC and brain reward circuitry can help us optimize the treatment of alcohol dependence using neuromodulatory brain stimulation in the DLPFC.

view more

Alcohol Intoxication by Binge Drinking Impairs Neuroplasticity Brain Stimulation

Loheswaran, G., Barr, M.S., Rajji, T.K., Blumberger, B., Le Foll, B., Daskalakis, Z.J.

2016

Binge drinking, resulting in acute alcohol intoxication, is considered an initial step in developing alcohol use disorders (AUDs). It has been suggested that alcohol intoxication may act on mechanisms of neuroplasticity to produce brain changes that contribute to the pathophysiology of AUDs. However, the effect of binge drinking on neuroplasticity has not been evaluated in humans.

view more

(2014). Screening and Treatment for Alcohol, Tobacco and Opioid Use Disorders: A Survey of Family Physicians across Ontario PLoS One

Loheswaran, G., Soklaridis, S., Selby, P., Le Foll, B.

2014

An online survey consisting of a series of 38 primarily close-ended questions was circulated to family physicians in Ontario. Rates of screening for alcohol, opioid and tobacco dependence, use of validated tools for screening, providing treatment for dependent individuals and the current barriers to the prescription of pharmacotherapies for these drug dependences were assessed.

view more

Contact