Dr. Jones is an internationally recognized expert in the development and examination of both behavioral and pharmacologic treatments for pregnant women and their children in risky life situations. Dr. Jones has received continuous funding from the United States National Institutes of Health since 1994 and has published over 175 publications, two books on treating substance use disorders (one for pregnant and parenting women and the other for a more general population of patients), numerous book and textbook chapters. She is a consultant for SAMHSA, the United Nations and the World Health Organization. Dr. Jones leads or is involved in projects in Afghanistan, the Southern Cone, the Republic of Georgia, South Africa, and the United States which are focused on improving the lives of children, women and families.
Dr. Jones is a professor in the Department of Obstetrics and Gynecology at the School of Medicine, University of North Carolina in Chapel Hill. She is also the executive director of UNC Horizons, a comprehensive drug treatment program for pregnant and parenting women and their drug-exposed children. She is also an Adjunct Professor in the Department of Psychology at UNC-Chapel Hill and an Adjunct Professor in the Psychiatry and Behavioral Sciences and in the Department of Obstetrics and Gynecology, School of Medicine at Johns Hopkins University.
Areas of Expertise (10)
Substance Use Disorders
Johns Hopkins Medicine: PhD, Psychology
Virginia Commonwealth University: BS, Psychology
- Executive Director of UNC Horizons
- Professor of Obstetrics and Gynecology
Wiegand SL, Stringer EM, Stuebe AM, Jones H, Seashore C, Thorp J.
To compare neonatal abstinence syndrome prevalence and characteristics among neonates born to women prescribed buprenorphine and naloxone compared with methadone during pregnancy.
Retrospective cohort analysis of mother-neonate dyads treated with either buprenorphine and naloxone or methadone during pregnancy. Primary neonatal outcomes included diagnosis of neonatal abstinence syndrome, neonatal abstinence syndrome peak scores, total amount of morphine used to treat neonatal abstinence syndrome (mg), and duration of treatment for neonatal abstinence syndrome (days). Secondary outcomes included head circumference, birth weight, length, preterm birth, neonatal intensive care unit admission, Apgar scores, and overall length of hospitalization.
From January 1, 2011, to November 30, 2013, we identified 62 mother-neonate dyads, 31 treated with methadone and 31 treated with buprenorphine and naloxone. Sixteen neonates (51.6%) in the methadone group were diagnosed with neonatal abstinence syndrome compared with eight (25.1%) in the buprenorphine and naloxone group (adjusted odds ratio 2.55, 95% confidence interval [CI] 1.31-4.98, P = .01). The buprenorphine and naloxone-exposed neonates had lower peak neonatal abstinence syndrome scores (9.0 ± 4.4 compared with 10.7 ± 3.7, multivariate-adjusted mean difference = -2.77, 95% CI -4.99 to -0.56, P = .02) and shorter overall hospitalization (5.6 ± 5.0 compared with 9.8 ± 7.4 days, multivariate-adjusted mean difference = -3.90, 95% CI, -7.13 to -0.67, P = .02). We found no other differences in primary or secondary outcomes.
In a cohort of pregnant patients treated with either methadone or buprenorphine and naloxone in pregnancy, newborns exposed to maternal buprenorphine and naloxone had less frequent neonatal abstinence syndrome. Additionally, neonates exposed to buprenorphine and naloxone had shorter overall hospitalization lengths.
Babies born to women addicted to opioids fare better when their mothers are treated with either
the addiction medication buprenorphine or methadone than babies whose mothers are not treated
at all. In this comparative effectiveness trial, buprenorphine was found to be superior to
methadone in reducing withdrawal symptoms in the newborns, according to a recent study
funded by the National Institute on Drug Abuse (NIDA), a component of the National Institutes
of Health. The study, conducted by a multi-disciplinary team of researchers from North America
and Europe, was published today in the New England Journal of Medicine.