Dr. David Weiner is a professor in the Division of Nephrology, Hypertension & Renal Transplantation. He directs a pre-clinical research program that is working to understand the fundamental mechanisms through which the kidneys maintain the correct acid-base balance in the body. His major clinical interests involve refractory hypertension, including specific expertise in primary hyperaldosteronism and renovascular hypertension, genetic causes of hypertension, such as Liddle's Syndrome, electrolyte disorders, such as Gitelman's and Bartters's syndrome, autosomal polycystic kidney disease, and chronic kidney disease associated with solid-organ transplantation (non-renal transplants, only). He also maintains an active practice in management of patients with chronic kidney disease of other etiologies.
Areas of Expertise (5)
Autosomal Dominant Polycystic Kidney Disease
Renal Tubular Acidosis
Role of the renal androgen receptor in sex differences in ammonia metabolismAmerican Journal of Physiology, Renal Physiology
Autumn N. Harris, et al.
There are sex differences in renal ammonia metabolism and structure, many of which are mediated by testosterone. The goal of the present study was to determine the role of renal expression of testosterone's canonical receptor, androgen receptor (AR), in these sexual dimorphisms.
Regulation of Rhcg, an ammonia transporter, by aldosterone in the kidneyThe Journal of Endocrinology
Koji Eguchi, et al.
Rhesus C glycoprotein (Rhcg), an ammonia transporter, is a key molecule in urinary acid excretion and is expressed mainly in the intercalated cells (ICs) of the renal collecting duct. In the present study we investigated the role of aldosterone in the regulation of Rhcg expression.
Prevalence and correlates of sleep apnea among US Veterans with chronic kidney diseaseJournal of Sleep Research
Muna T. Canales, et al.
The prevalence and correlates of sleep apnea (SA) among Veterans with chronic kidney disease (CKD), a population at high risk of both SA and CKD, are unknown. We performed a cross-sectional analysis of 248 Veterans (18–89 years) selected only for presence of moderate to severe CKD. All participants underwent full, unattended polysomnography, measurement of renal function and a sleepiness questionnaire.