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Janet Robishaw, Ph.D. - Florida Atlantic University. Boca Raton, FL, US

Janet Robishaw, Ph.D. Janet Robishaw, Ph.D.

Senior Associate Dean for Research & Chair | Florida Atlantic University

Boca Raton, FL, UNITED STATES

Janet Robishaw is an expert in biochemical mechanisms and the molecular cloning of the newly discovered the heterotrimeric G-proteins.

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Biography

Janet D. Robishaw received her B.S. degree from Central Michigan University with a Double Major in Chemistry and Biology followed by a Ph.D. in Physiology from Pennsylvania State University College of Medicine. Her doctoral research focused on characterizing the biochemical mechanisms underlying cardiac energy metabolism. Her postdoctoral training was conducted in the laboratory of Alfred G. Gilman at the Southwestern Medical School, University of Texas Health Sciences Center. Robishaw’s post-doctoral research revolved around the structure, function and first molecular cloning of the newly discovered the heterotrimeric G-proteins. Her work contributed to the discovery of heterotrimeric G-proteins and their roles in signal transduction for which Gilman’s team was awarded the 1994 Nobel Prize in Physiology and Medicine. While attaining the rank of full professor at Pennsylvania State University College of Medicine and Associate Director of Translational Research at Geisinger Health System, her research utilized a broad range of molecular, biochemical, physiological, and genetic approaches to decipher how structural heterogeneity of the heterotrimeric G-proteins mediates such diverse functions as cardiovascular and cognitive performance. More recently, her work has delved into understanding their roles in various diseases processes. Altogether, Robishaw's research has been continuously supported for >30 years by the National Institutes of Health and the results have appeared in >100 peer-reviewed papers, reviews, and book chapters. Among multiple honors, she has been named an established investigator of the American Heart Association.

Areas of Expertise (4)

Heterotrimeric G-proteins

Biochemical Mechanisms

Chemistry and Biology

Molecular Cloning

Accomplishments (2)

Ad Hoc Member Vascular Biology

National Institutes of Health

Glue Grant

National Institutes of Health

Education (2)

Pennsylvania State University: Ph.D. 1983

Central Michigan University: B.S.

Affiliations (3)

  • American Society for Biochemistry and Molecular Biology, Member
  • American Association for Advancement of Science, Member
  • International Society for Heart Research, Member

Selected Media Appearances (5)

Wearable technology could play key role in COVID-19 diagnosis, contact tracing

UPI  

2020-06-19

"The best analogy [to describe the potential benefits of wearable technology] is the difference between a video recording and a snapshot," Janet Robishaw, senior associate dean for research at Florida Atlantic University's Schmidt College of Medicine, one of the sites of the Oura study, told UPI.

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Real-Time Data Ring May Predict COVID-19 in Healthcare Workers

Health IT Analytics  

2020-05-28

“We were very interested in the Oura ring because it provides continuous information that is very instructive in helping people understand that they might be getting sick without even realizing it,” said Janet Robishaw, PhD, principal investigator, senior associate dean for research and chair of the Department of Biomedical Sciences in FAU’s Schmidt College of Medicine.

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Genes study seeks to identify patients susceptible to opioid addiction

Wink News  

2018-11-07

"Janet Robishaw, PhD, Senior Associate Dean for Research & Chair of Biomedical Sciences at Charles E Schmidt College of Medicine from Florida Atlantic University says the overprescribing of painkillers like Vicodin and oxycontin has led to a condition called opioid use disorder."

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Predicting those at risk for opioid abuse

WNDU  

2018-11-01

"Dr. Janet Robishaw says the overprescribing of painkillers like Vicodin and OxyContin has led to a condition called opioid use disorder."

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University researchers step up to tackle opioid crisis

Sun Sentinel  

2018-02-02

"Janet Robishaw’s research, also in the Charles E. Schmidt College of Medicine, focuses on why some people get addicted and some don’t. Robishaw is studying opioids prescribed for pain, such as Vicodin, morphine and OxyContin."

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Selected Articles (3)

Sarcomeric Variants in an Imaging-Based, Cardiovascular Phenotype From the Discovehr Cohort CirculationF

Janet Robishaw et al.

2018 We sought to assess and compare the correlation of genetic and clinical risk to outcomes in an imaging cohort.

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Geranylgeranylation signals to the Hippo pathway for breast cancer cell proliferation and migration OncogeneF

Janet Robishaw et al.

2015 Protein geranylgeranylation (GGylation) is an important biochemical process for many cellular signaling molecules. Previous studies have shown that GGylation is essential for cell survival in many types of cancer. However, the molecular mechanism mediating the cell survival effect remains elusive. In this report, we show that the Hippo pathway mediates GGylation-dependent cell proliferation and migration in breast cancer cells. Blockade of GGylation enhanced phosphorylation of Mst1/2 and Lats1, and inhibited YAP and TAZ activity and the Hippo-YAP/TAZ pathway-dependent transcription. The effect of GGylation blockade on inhibition of breast cancer cell proliferation and migration is dependent on the Hippo-YAP/TAZ signaling, in which YAP appears to regulate cell proliferation and TAZ to regulate cell migration. Furthermore, GGylation-dependent cell proliferation is correlated with the activity of YAP/TAZ in breast cancer cells. Finally, Gγ and RhoA are the GGylated proteins that may transduce GGylation signals to the Hippo-YAP/TAZ pathway. Taken together, our studies have demonstrated that the Hippo-YAP/TAZ pathway is essential for GGylation-dependent cancer cell proliferation and migration.

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Synergistic roles for G-protein γ3 and γ7 subtypes in seizure susceptibility as revealed in double knock-out mice Journal of Biological ChemistryF

Janet Robishaw et al.

2012 The functions of different G-protein αβγ subunit combinations are traditionally ascribed to their various α components. However, the discovery of similarly diverse γ subtypes raises the possibility that they may also contribute to specificity. To test this possibility, we used a gene targeting approach to determine whether the closely related γ3 and γ7 subunits can perform functionally interchangeable roles in mice. In contrast to single knock-out mice that show normal survival, Gng3−/−Gng7−/− double knock-out mice display a progressive seizure disorder that dramatically reduces their median life span to only 75 days. Biochemical analyses reveal that the severe phenotype is not due to redundant roles for the two γ subunits in the same signaling pathway but rather is attributed to their unique actions in different signaling pathways. The results suggest that the γ3 subunit is a component of a Gi/o protein that is required for γ-aminobutyric acid, type B, receptor-regulated neuronal excitability, whereas the γ7 subunit is a component of a Golf protein that is responsible for A2A adenosine or D1 dopamine receptor-induced neuro-protective response. The development of this mouse model offers a novel experimental framework for exploring how signaling pathways integrate to produce normal brain function and how their combined dysfunction leads to spontaneous seizures and premature death. The results underscore the critical role of the γ subunit in this process.

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