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Jason Pitts, Ph.D.

Director of the Biology of Global Health 4+1 Program | Associate Professor Baylor University

  • Waco TX

Investigates the sensory neuronal basis for behaviors in arthropod disease vectors such as mosquitoes carrying Dengue or Zika viruses.

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Summer means mosquitoes, and with more of the pesky insects buzzing around, more people are grappling with mosquito bites and their consequences, ranging from an itchy inconvenience to serious health risks from vector-borne diseases. If it seems like mosquitoes bite you more than others, you may be right, according to Baylor University mosquito expert Jason Pitts, Ph.D. It simply may come down to how you smell. An associate professor of biology and director of Baylor’s Biology of Global Health 4+1 Program, Pitts focuses his research on mosquitoes and their complex odor-receptors, or sense of smell, to better understand how they locate food sources crucial to survival and reproduction. His impactful work is helping develop new mosquito control methods, which ultimately could lead to a decrease in vector-borne disease transmission around the world. “Many insects find their way around the world through their sense of smell, even more than vision,” Pitts said. “Mosquitoes and other insects really are adept at finding places to lay their eggs, finding flowers on which to feed or finding people on which to blood feed just by the sense of smell.” A mosquito’s strong sense of smell is critical to its survival. While all mosquitoes feed from nectar, only females bite humans and other mammals. They need the blood to support egg development in reproduction, and they rely heavily on scent to locate a host, Pitts said. “As we sweat, we emit volatile odors – or strong smells – which can be very attractive to mosquitoes,” Pitts said, adding that these odors include carboxylic acids, a key component in human sweat, which vary from person to person and can determine how appealing someone is to mosquitoes. Mosquitoes detect these chemicals in a similar way to how humans process smells. Humans have nerves in their nasal passages that, if tuned, will send signal receptors to the brain – the same process for mosquitoes, guiding them toward a potential meal, Pitts said. Because of their efficiency in locating human hosts, mosquitoes are considered to be the deadliest creatures in the world, responsible for more than 700,000 deaths each year from vector-borne diseases they transmit, including yellow fever, Zika, dengue, malaria and West Nile virus. Four D’s of mosquito prevention Whether you are a favorite meal among mosquitoes or not, Pitts recommends following the “Four D’s” of preventing mosquito breeding and bites – Dress, Drain, DEET and Dusk/Dawn. Dress Mosquitoes are attracted to darker colors, so wear light-colored, loose-fitting, long-sleeved shirts and long pants to protect yourself from potential bites. Drain The most important thing anyone can do is to reduce breeding sources for mosquitoes by draining stagnant water. If you have standing water in any kind of container in your yard, get in the habit of emptying those containers, including children’s swimming pools, which should be emptied at least once a week. Defend with DEET The most effective repellent is EPA-approved DEET (N-Diethyl-meta-toluamide). “Once a mosquito lands on the skin, they taste the skin to decide whether this is a good host or not,” Pitts said. “They can actually taste DEET, which is a long-range repellent. They can smell it and avoid it. When they taste it, they will also fly away.” Dusk / Dawn Mosquitoes are more active at dusk and at dawn, when the sun is rising or setting. Avoiding these times will help you avoid bites. If you like to take a morning run or walk at dusk, make sure to apply DEET repellent and wear light-colored clothing. Looking to know more or arrange an interview? Simply click on the icon below and connect with the expert.

Jason Pitts, Ph.D.

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Biography

Jason Pitts is an Associate Professor in the Department of Biology at Baylor University. His laboratory investigates the sensory neuronal basis for behaviors in arthropod disease vectors, especially mosquitoes that transmit Zika, Dengue and other arboviruses.

Areas of Expertise

Zika Virus
Mosquito Life Cycle
Arthropod Disease Vectors
Mosquito-borne Diseases
Dengue Fever

Education

Vanderbilt University

Ph.D.

Indiana University

M.A.

Ball State University

B.S.

Media Appearances

World Mosquito Day: How Baylor Biologists Battle Mosquito Vector Diseases

Baylor University  online

2024-08-20

Mosquitoes are global agents of the spread of diseases – like malaria, dengue, Zika and West Nile virus – which lead to more than a million human deaths per year. To fight this persistent global health threat, Baylor University biology researchers Tamar Carter, Ph.D., Jason Pitts, Ph.D., and Cheolo Sim, Ph.D., and their respective labs are working to understand mosquito biology, behavior and ecology leading to breakthroughs in disease prevention and control strategies, ultimately saving millions of lives worldwide.

“While most people assume that we are not at risk of these diseases in the U.S., events are showing up here with transmitted cases of malaria in 2023 in Florida, Texas and Maryland,” Pitts said. “This was highly unusual and speaks to the ongoing need for vector research, surveillance and control.”

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New Research on Mosquito Odorant Receptors Advances Understanding of Feeding Behaviors

Baylor University  online

2024-08-05

Baylor University mosquito researchers, led by Jason Pitts, Ph.D., who specializes in vector biology and global health, have researched the complex odor-receptors – or sense of smell – of mosquitoes to help understand how they find meals. Their latest research – “Odorant receptors for floral- and plant-derived volatiles in the yellow fever mosquito, Aedes aegypti” – is published in the journal, PLOS ONE.

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Dr. Tamar Carter and Dr. Jason Pitts

Baylor Connections  online

2019-06-14

Dr. Tamar Carter and Dr. Jason Pitts are Baylor biologists who study mosquitoes and use their findings to fight disease. In this Baylor Connections, they share information about one of the ubiquitous and unwelcome guests, both close to home and abroad. Learn tips to diminish the impact of mosquitoes on summer plans and discover how, more broadly, mosquito research can stop the spread of disease in impoverished communities around the world.

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Articles

The conserved IR75 subfamily mediates carboxylic acid detection in insects of public health and agricultural importance

Journal of Insect Science

2025

Insects perceive and respond to carboxylic acids (CAs), amines, and aldehydes primarily via conserved ionotropic receptors (IRs). These receptors form the basis for a second olfactory system distinct from the well-characterized odorant receptors. Neurons expressing IRs are housed in dedicated sensilla and innervate glomeruli, separate from those innervated by odorant receptor neurons. The IR8a co-receptor is highly conserved across insect orders and, together with ionotropic receptor tuning receptors, primarily detects CAs. The conservation of genes and the anatomical separation of neural pathways underscore the importance of these compound classes and CAs, specifically in insect chemical ecology. We provide a summary of carboxylic acid detection in insects, focusing on dipteran and lepidopteran species of significance to public health and agriculture.

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Functional Characterization of a Female-Biased Chemoreceptor of the Codling Moth (Cydia pomonella) Responding to Aldehydes and Other Volatile Compounds

Journal of Chemical Ecology

2025

With the advent of semiochemical-based control strategies used to mitigate damage of agricultural pest moths, many studies have focused on the function of male-specific putative pheromone receptors (PRs). In this investigation, we instead isolated, heterologously expressed, and functionally characterized a female-biased candidate PR, CpomOR22, from the codling moth, Cydia pomonella. Using transgenic Drosophila melanogaster for single sensillum recording (SSR) and gas-chromatographic SSR, we tested both synthetic ligands and various apple headspace extracts, identifying saturated and unsaturated aldehydes (nonanal, decanal, undecanal, dodecanal; (Z)-4-undecenal and (Z)-6-undecenal) among the most active ligands.

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The Dysregulation of Tuning Receptors and Transcription Factors in the Antennae of Orco and Ir8a Mutants in Aedes aegypti Suggests a Chemoreceptor …

Insects

2025

Olfaction has been extensively studied in the yellow fever mosquito, Aedes aegypti. This species uses its sense of smell to find blood hosts and other resources, contributing to its impact as a vector for human pathogens. Two major families of protein-coding genes, the odorant receptors (Ors) and the ionotropic receptors (Irs), provide the mosquito with sensitivities to distinct classes of volatile compounds in the antennae. Individual tuning receptors in both families require co-receptors for functionality: Orco for all Ors, and Ir8a for many Irs, especially ones that are involved in carboxylic acid detection. In Drosophila melanogaster, disruptions of Orco or Ir8a impair receptor function, tuning receptor expression, and membrane localization, leading to general anosmia.

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