Jay Sanguinetti, PhD
Research Assistant Professor | Vielight
Albuquerque, NM, UNITED STATES
Dr. Sanguinetti is a neurocognition expert, specializing in therapeutic applications of noninvasive brain stimulation
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Industry Expertise (9)
Mental Health Care
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Areas of Expertise (3)
Transcranial Electrical Stimulation
Transcranial Magnetic Stimulation
Transcranial Ultrasound
Education (2)
University of Arizona: PhD 2015
University of North Carolina at Wilmington: BA, Psychology and Philosophy 2007
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Media Appearances (1)
Your Brain ‘Sees’ Things Even When You Don’t
Psychological Science online
"The research, led by Jay Sanguinetti of the University of Arizona, challenges currently accepted models about how the brain processes visual information..."
Articles (2)
Increased alpha indexes inhibitory competition across a border
Vision Research
2016 Figure–ground assignment is thought to entail inhibitory competition between potential objects on opposite sides of a shared border; the winner is perceived as the figure, and the loser as the shapeless ground. Computational models and response time measures support this understanding but to date no online measure of inhibitory competition during figure–ground assignment has been reported. The current study assays electroencephalogram (EEG) alpha power as a measure of inhibitory competition during figure–ground assignment. Activity in the EEG alpha band has been linked to functional inhibition in the brain, and it has been proposed that increased alpha power reflects increased inhibition. In 2 experiments participants viewed silhouettes designed so that the insides would be perceived as figures. Real-world silhouettes depicted namable objects. Novel silhouettes depicted novel objects on the insides of their borders, but varied in the amount of hypothesized cross-border competition for figural status: In “Low-Competition” silhouettes, the borders suggested novel objects on the outside as well as on the inside. In “High-Competition” silhouettes the borders suggested portions of real-world objects on the outside; these compete with the figural properties favoring the inside as figure. Participants accurately categorized both types of novel silhouettes as “novel” objects and were unaware of the real world objects suggested on the outside of the High-Competition silhouettes. In both experiments, we observed more alpha power while participants viewed High- rather than Low-Competition novel silhouettes. These are the first results to show via an online index of neural activity that figure assignment entails inhibitory competition.
Topographic deficits in alpha-range resting EEG activity and steady state visual evoked responses in schizophrenia
Schizophrenia Research
2015 Deficits in both resting alpha-range (8-12Hz) electroencephalogram (EEG) activity and steady state evoked potential (SSVEP) responses have been reported in schizophrenia. However, the topographic specificity of these effects, the relationship between resting EEG and SSVEP, as well as the impact of antipsychotic medication on these effects, have not been clearly delineated. The present study sought to address these questions with 256 channel high-density EEG recordings in a group of 13 schizophrenia patients, 13 healthy controls, and 10 non-schizophrenia patients with psychiatric diagnoses currently taking antipsychotic medication. At rest, the schizophrenia group demonstrated decreased alpha EEG power in frontal and occipital areas relative to healthy controls. With SSVEP stimulation centered in the alpha band (10Hz), but not with stimulation above (15Hz) or below (7Hz) this range, the occipital deficit in alpha power was partially reverted. However, the frontal deficit persisted and contributed to a significantly reduced topographic relationship between occipital and frontal alpha activity for resting EEG and 10Hz SSVEP alpha power in schizophrenia patients. No significant differences were observed between healthy and medicated controls or between medicated controls and schizophrenia. These findings suggest a potential intrinsic deficit in frontal eyes-closed EEG alpha oscillations in schizophrenia, whereby potent visual stimulation centered in that frequency range results in an increase in the occipital alpha power of these patients, which however does not extend to frontal regions. Future research to evaluate the cortical and subcortical mechanisms of these effects is warranted.