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Jennifer S.  Wayne, Ph.D. - VCU College of Engineering. Engineering East Hall, Room E2238, Richmond, VA, US

Jennifer S. Wayne, Ph.D. Jennifer S.  Wayne, Ph.D.

Professor, Department of Biomedical Engineering | VCU College of Engineering

Engineering East Hall, Room E2238, Richmond, VA, UNITED STATES

Professor of Biomedical Engineering and Orthopaedic Surgery & Director, Orthopaedic Research Laboratory






Orthopaedic Research Lab




Dr. Wayne's research focuses on experimental and computational modeling of diarthrodial joint function,
structural stability of fixation constructs and articular cartilage: normal function, reparative techniques.

Her current projects include computational modeling of diarthrodial joint function, corrective procedures for flatfoot deformity, acetabular cup fit, finite element analyses of articular cartilage behavior and reparative approaches for damaged articular surfaces.

Industry Expertise (3)



Program Development

Areas of Expertise (4)

Experimental and computational modeling of diarthrodial joint function

Structural stability of fixation constructs

Articular cartilage: normal function reparative techniques

Reparative Techniques

Accomplishments (8)

H.R. Lissner Medal, ASME (professional)

2019 The H.R. Lissner Medal recognizes outstanding achievements in the field of bioengineering.

ABET Program Evaluator (professional)

2013 - Present

Executive Committee, Orthopaedic Research Society (professional)

2009 - 2013

Executive Committee, Bioengineering Division of ASME (professional)

2006 - 2010

Engineer of the Year, Richmond Joint Engineer's Council (professional)


Fellow, American Society of Mechanical Engineers (professional)


Fellow, American Institute for Medical and Biological Engineering (professional)


AOFAS Roger Mann Award – coauthor on awarded manuscript (professional)


Education (3)

University of California at San Diego: Ph.D., Bioengineering

Tulane University: M.S., Biomedical Engineering

Virginia Polytechnic Institute and State University: B.S., Engineering Science and Mechanics

Affiliations (7)

  • American Society of Mechanical Engineers
  • Orthopaedic Research Society
  • Biomedical Engineering Society
  • International Cartilage Repair Society
  • Tau Beta Pi National Honor Engineering Society
  • Phi Kappa Phi National Honor Society
  • Alpha Phi Omega National Service Fraternity Life Member

Research Focus (3)

Computational modeling of diarthrodial joint function

Foot/ankle, Wrist/hand, Elbow, Shoulder, Corrective procedures for flatfoot deformity

Structural performance of:

Growth & remodeling constructs; Repaired fractures, fusions, joint arthroplasties

Finite element analyses of biological tissues and medical devices

Poroelastic approach to soft biological tissue behavior, Design of medical devices & structures

Patents (2)

Medial Column (MECO) Fixation Device, Method, and System



An orthopedic implant device and system support the fusion of bones in the medial column of the human foot. An exemplary implant uses an improved lag screw and supplemental components, including a washer plate and transverse screws which penetrate transverse through holes in the shaft of the lag screw. Additionally, a surgical procedure is described which may employ such an implant. The improved lag screw may be inserted at the plantar surface of the first metatarsal and support the fusion of, for example, the transverse tarsal joint, the cuneonavicular joint, and the tarsometatarsal joint.

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Tibiotalar Arthrodesis Guide



A Tibiotalar Arthrodesis Guide (TAG) used for fusion of the talus to the tibia is comprised of several basic components. The main component is a straight guide post upon which other components can slide. A curved arm is featured at the end of the straight guide post, featuring points at the ends which serve as indicators of the pins' exit sites based upon the lines of action of the parallel pins. The parallel guide cylinders are positioned on a movable arm which translates superiorly and inferiorly on the guide post of the handle, allowing a surgeon to adjust the device for varying ankle sizes. A “home-run” pin guide cylinder for a home-run guide pin is oriented superiorly and at an angle to the parallel guide cylinders. Using a similar concept as the parallel guide cylinders, the “home-run” guide is also attached to a movable arm that can translate inferiorly and superiorly along the main guide post. A medial guide cylinder for a medial guide pin passes through one of a plurality of holes in a vertical guide arm. The surgeon has the flexibility to utilize either the “home-run” or medial pins, depending on the needs of the patient and preference of the surgeon and, in either case, the “home-run” and medial pin pass between the two parallel pins.

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Courses (3)


* Application of solid mechanics to the development and transmission of loads/stresses in biomechanical structures * Mechanical behavior of biological tissues and the importance of the structure/function relationship * Increased complexity of material properties of biological tissues, including such issues as anisotropy, nonlinearity, viscoelasticity, poroelasticity * Comparative mechanical behavior of biological tissues to engineered/natural materials * Experimental techniques for characterizing material behavior with materials testing equipment and digital control/acquisition

Finite element analysis

Theoretical basis and practical application of this numerical approach to solving field problems governed by differential or integral equations.

Continuum mechanics

Use of indicial notation; development of vector bases and tensors; conservation laws in global, local and point forms; development of multiple classes of constitutive equations; material symmetry; nonlinear theories

Selected Articles (13)

Automated femoral version estimation without the distal femur

Journal of Orthopaedic Research, 2018

Femoral version impacts the long-term functioning of the femoroacetabular joint. Accurate measurements of version are thus required for success in total hip arthroplasties and hip reconstructive surgeries. These are impossible to obtain without visualization of the distal femur, which is often unavailable preoperatively as the majority of imaging scans are isolated to the pelvis and proximal femur. We developed an automated algorithm for identifying the major landmarks of the femur. These landmarks were then used to identify proximal axes and create a statistical shape model of the proximal femur across 144 asymptomatic femora. With six proximal axes selected, and 200 parameters (distances and angles between points) from the shape model measured, the best-fitting linear correlation was found. The difference between true version and version predicted by this model was 0.00 ± 5.13° with a maximum overestimation and underestimation of 11.80 and 15.35°, respectively. The mean absolute difference was 4.14°. This model and its prediction of femoral version are a substantial improvement over pre-operative 2D or intra-operative visual estimation measures.

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Neural network prediction of ligament stiffnesses for the enhanced predictive ability of a patient-specific, computational foot/ankle model

Journal of Biomechanical Engineering, 2017

Computational models of diarthrodial joints serve to inform the biomechanical function of these structures, and as such, must be supplied appropriate inputs for performance that is representative of actual joint function. Inputs for these models are sourced from both imaging modalities as well as literature. The latter is often the source of mechanical properties for soft tissues, like ligament stiffnesses; however, such data are not always available for all the soft tissues nor is it known for patient-specific work. In the current research, a method to improve the ligament stiffness definition for a computational foot/ankle model was sought with the greater goal of improving the predictive ability of the computational model. Specifically, the stiffness values were optimized using artificial neural networks (ANNs); both feedforward and radial basis function networks (RBFNs) were considered. Optimal networks of each type were determined and subsequently used to predict stiffnesses for the foot/ankle model. Ultimately, the predicted stiffnesses were considered reasonable and resulted in enhanced performance of the computational model, suggesting that artificial neural networks can be used to optimize stiffness inputs.

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Patient specific computational models to optimize surgical correction for flatfoot deformity.

Journal of Orthopaedic Research, 2017

Several surgically corrective procedures are considered to treat Adult Acquired Flatfoot Deformity (AAFD) patients, relieve pain, and restore function. Procedure selection is based on best practices and surgeon preference. Recent research created patient-specific models of AAFD to explore their predictive capabilities and examine effectiveness of the surgical procedure used to treat the deformity.

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Novel potential marker for native anteversion of the proximal femur.

Journal of Orthopaedic Research, 2016

Identifying native femoral version from proximal femoral landmarks would be of benefit both for preoperative assessment as well as intraoperatively. To identify potential markers for femoral anteversion, an empirical framework was developed for orientation-independent analysis of the proximal femur from pelvic CT to allow for segmentation of the proximal femur into five constituent regions: Femoral head, femoral neck, greater trochanter, lesser trochanter and femoral shaft.

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High Risk of Surgical Glove Perforation From Surgical Rotatory Instruments.

Clinical Orthopaedics & Related Research, 2016

Surgical gloves can be damaged during the course of a procedure, which can place the surgeon and patient at risk. Glove perforation may not always be readily apparent, and determining the risk factors for glove perforation can aid the surgeon in deciding when a glove change is advisable. Time of wear and needle sticks have been well studied; however, other mechanisms including mechanical stress from surgical equipment have had limited evaluation to date.

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Application of a three-dimensional computational wrist model to proximal row carpectomy.

Journal of Biomechanical Engineering, 2015

A three-dimensional (3D) computational model of the wrist examined the biomechanical effects of the proximal row carpectomy (PRC), a surgical treatment of certain wrist degenerative conditions but with functional consequences. Model simulations, replicating the 3D bony anatomy, soft tissue restraints, muscle loading, and applied perturbations, demonstrated quantitatively accurate responses for the decreased motions subsequent to the surgical procedure. It also yielded some knowledge of alterations in radiocarpal contact force which likely increase contact pressure as well as additional insight into the importance of the triangular fibrocartilage complex and retinacular/capsular structures for stabilizing the deficient wrist. As better understanding of the wrist joint is achieved, this model could serve as a useful clinical tool.

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Effects of Degree of Surgical Correction for Flatfoot Deformity in Patient-Specific Computational Models.

Annals of Biomedical Engineering, 2015

A cohort of adult acquired flatfoot deformity rigid-body models was developed to investigate the effects of isolated tendon transfer with successive levels of medializing calcaneal osteotomy (MCO). Following IRB approval, six diagnosed flatfoot sufferers were subjected to magnetic resonance imaging (MRI) and their scans used to derive patient-specific models. Single-leg stance was modeled, constrained solely through physiologic joint contact, passive soft-tissue tension, extrinsic muscle force, body weight, and without assumptions of idealized mechanical joints. Surgical effect was quantified using simulated mediolateral (ML) and anteroposterior (AP) X-rays, pedobarography, soft-tissue strains, and joint contact force.

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A novel approach for determining three-dimensional acetabular orientation: results from two hundred subjects.

Journal of Bone & Joint Surgery (Am), 2014

The inherently complex three-dimensional morphology of both the pelvis and acetabulum create difficulties in accurately determining acetabular orientation. Our objectives were to develop a reliable and accurate methodology for determining three-dimensional acetabular orientation and to utilize it to describe relevant characteristics of a large population of subjects without apparent hip pathology.

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Plantar measurements to determine success of surgical correction of Stage IIb adult acquired flatfoot deformity.

Journal of Foot & Ankle Surgery, 2014

Adult acquired flatfoot deformity is a degenerative disease causing medial arch dysfunction. Surgical correction has typically involved tendon reconstruction with calcaneal osteotomy; however, the postoperative changes have not been fully characterized. The present study assessed the success of surgical correction of Stage IIb adult acquired flatfoot deformity through changes in plantar pressures and patient-generated outcome scores.

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Plantar forces in flexor hallucis longus versus flexor digitorum longus transfer in adult acquired flatfoot deformity.

Foot & Ankle International, 2013

Flexor hallucis longus (FHL) and flexor digitorum longus (FDL) tendon transfers are frequently used to restore the function of a deficient tibialis posterior tendon in stage II adult acquired flatfoot deformity (AAFD). Either transfer causes some loss in toe flexion force, although the decision to tenodese the cut tendon to restore associated function remains controversial. This study quantified changes in plantar force before and after tendon transfer and with or without distal tenodesis in a cadaveric model.

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Effects of surgical correction for the treatment of adult acquired flatfoot deformity: A computational investigation

Journal of Orthopaedic Research, 2011

Computational models of the foot/ankle complex were developed to predict the biomechanical consequences of surgical procedures that correct for Stage II adult acquired flatfoot deformity. Cadaveric leg and foot bony anatomy was captured by CT imaging in neutral flexion and imported to the modeling software.

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Computational Model of the Human Elbow and Forearm: Application to Complex Varus Instability

Annals of Biomedical Engineering, 2011

Computational modeling is an effective way to predict the response of complex systems to perturbations that are difficult or impossible to measure experimentally. A computational model of the human elbow was developed wherein joint function was dictated by three-dimensional osteoarticular interactions, soft tissue constraints, muscle action, and external loading. The model was validated against two cadaveric experiments that examined the significance of coronoid process (CP) fractures, lateral ulnar collateral ligament (LUCL) ruptures, and radial head (RH) resection in varus stability.

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Biomechanical Evaluation of a Locking and Nonlocking Reconstruction Plate in an Osteoporotic Calcaneal Fracture Model

Foot and Ankle International, 2011

This study evaluated the effects of locking vs nonlocking configuration on the biomechanical performance of a calcaneal reconstruction plate in an osteoporotic cadaveric model.

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