Dr. Gilmore’s research focuses on pre- and early postnatal brain development and how it contributes to risk for schizophrenia. It has been known for years that early brain development is abnormal in people who go on to develop schizophrenia, though few have attempted to study this in a systematic way. Dr. Gilmore and colleagues have developed MR imaging and image analysis methodologies to study very early human brain in children at high risk for schizophrenia. They also study normal brain development from birth to age 6, as little is known about how the normal brain develops in this time period of risk for schizophrenia and other neurodevelopmental disorders. They apply structural MRI, diffusion tensor imaging to study white matter development, and resting state fMRI to study functional network development. Current longitudinal studies include: 1) early brain development in children at risk for schizophrenia and bipolar illness, 2) a twin study to determine genetic and environmental contributions to early brain development, and 3) a study of structural brain development in normal children and its relationship to cognitive development.
Areas of Expertise (7)
Community Mental Health
Pre- and Early Post-Natal Brain Development
University of North Carolina at Chapel Hill Medical School: MD, Psychiatry and Neurology
University of North Carolina at Chapel Hill Medical School: Research Fellow, Psychiatry
Graduate Hospital: Intern, Department of Surgery
New York Hospital-Cornell Medical Center: Resident, Department of Surgery
University of Virginia: BA
Media Appearances (1)
WRAL Documentary: A Call for Help
A Call for Help" examines the increasing frequency of interactions between law enforcement officers and the mentally ill and features an interview with John Gilmore, MD.
Development of amygdala functional connectivity during infancy and its relationship with 4-year behavioral outcomesBiological Psychiatry: Cognitive Neuroscience and Neuroimaging
Andrew Paul Salzwedel, Rebecca Stephens, Barbara D. Goldman, Weili Lin, John H. Gilmore, and Wei Gao
Abstract Background The amygdala represents a core node in the human brain’s emotional signal processing circuitry. Given its critical role, both the typical and atypical functional connectivity patterns of the amygdala have been extensively studied in adults. However, the development of amygdala functional connectivity during infancy is less well studied; thus, our understanding of the normal growth trajectory of key emotion-related brain circuits during a critical period is limited.