Juliet Daniel

Professor of Biology McMaster University

  • Hamilton ON

Dr. Daniel is a Cancer Biologist with expertise in breast cancer, racial disparities in cancer, and diversity issues in higher education.

Contact

Media

Social

Biography

Dr. Juliet Daniel is a Professor in the Department of Biology at McMaster University. Dr. Daniel received her B.Sc. from Queen’s University (Kingston), her Ph.D. from UBC (Vancouver) and completed postdoctoral fellowships at St. Jude Children’s Research Hospital and Vanderbilt University in Tennessee. At McMaster, Dr. Daniel’s research team focuses on understanding how disruptions in cell-cell adhesion and signaling contribute to cancer initiation and progression. Dr. Daniel is most interested in the aggressive triple negative breast cancer (TNBC) subtype that is associated with poor prognosis due to an absence of specific therapies. Intriguingly, young pre-menopausal women of African ancestry have a higher TNBC prevalence and mortality compared to other ethnicities despite a lower incidence and lifetime risk of breast cancer. Since socio-economic status does not fully explain the racial disparity in TNBC prevalence and mortality, Dr. Daniel's research team seeks to identify unique biomarkers or gene mutations that may explain this racial disparity. Her team will utilize genetic, genomic, molecular and cell biology techniques to analyze TNBC tissues from populations of shared African ancestry (Caribbean and West Africa) to identify genetic risk factors that can be used as biomarkers to diagnose or develop therapies for TNBC patients worldwide.

Areas of Expertise

Breast Cancer Research
Colon Cancer Research
Cadherin-mediated cell adhesion
Cell & Molecular Biology
Developmental Biology
Kaiso and transcription factors
Women in Science and Engineering

Accomplishments

Black Arts and Innovation Expo Trailblazer Award 2016

Excelovate and First Book Canada, Toronto, ON

Gordon and Jean Southam Fellowship 2014

Association of Commonwealth Universities (ACU) Titular Fellowship, UK

YWCA Hamilton – Woman of Distinction Award 2014

Hamilton, ON

Show All +

Education

Queen's University

B.Sc. Hons

Life Sciences

1987

University of British Columbia

Ph.D.

Microbiology

1993

Affiliations

  • Associate Member, Dept. of Oncology, McMaster University
  • Associate Member, Farncombe Family Digestive Health Research Institute, McMaster University
  • Member, American Association for Cancer Research (AACR)
  • Member, Canadian Society for Molecular Biosciences
  • Member, American Society for Cell Biology (ASCB)
Show All +

Languages

  • English

Media Appearances

Breast Cancer Researchers Are Zeroing in On Inventive Solutions To Breast Cancer

Personal Health News  

2015

View More

IDENTIFICATION OF UNIQUE TRIPLE NEGATIVE BREAST CANCER (TNBC) BIOMARKERS IN WOMEN OF AFRICAN ANCESTRY (WAA

CBCF  

2015

View More

Targeted Research Helps Change the Breast Cancer Landscape

Market Wired  

2015

View More

Event Appearances

Think Beyond Love Pink Breast Cancer Awareness

Think Beyond Love Pink Breast Cancer Awareness Campaign  G98.7 FM, The Way We Groove

2016-10-30

Think Beyond Love Pink Breast Cancer Awareness

Think Beyond Love Pink Breast Cancer Awareness Interview  ROGERS TV Daytime, Durham, Ontario

2016-11-01

Research Grants

Identification of unique triple negative breast cancer (TNBC) biomarkers in Women of African Ancestry (WAA)

CBCF

2015-2018

POZ-ZF transcription factors in signaling and development.

NSERC (Operating)

2015-2020

Identification of a TNBC Signature in a Unique Cohort of Women of African Ancestry (WAA)

JHCCF (Operating)

2014-2015

Show All +

Articles

Kaiso depletion attenuates transforming growth factor-β signaling and metastatic activity of triple negative breast cancer cells.

Oncogenesis

2016-03-21

Bassey-Archibong BI, Kwacien JM, Milosavljevic S, Hallett RM, Rayner LGA, Erb MJ, Crawford-Brown CJ*, Stephenson KB, Bedard P-A, Hassell JA and Daniel JM. Kaiso depletion attenuates transforming growth factor-β signaling and metastatic activity of triple negative breast cancer cells. (2016) NPG-Oncogenesis 5, e208 Published online 21st March 2016

Kaiso, a transcriptional repressor, promotes cell migration and invasion of prostate cancer cells through regulation of miR-31 expression.

Oncotarget

Wang H, Liu W, Black S, Turner O, Daniel JM, Dean-Colomb W, He QP, Davis M and Yates C. 
Kaiso, a transcriptional repressor, promotes cell migration and invasion of prostate cancer cells through regulation of miR-31 expression. (2016) Oncotarget, 7(5): 5677-5689

Methylation-dependent regulation of hypoxia inducible factor-1 alpha gene expression by the transcription factor Kaiso.

BBA- Gene Regulatory Mechanisms

Pierre CC, Longo J*, Hallett RM, Milosavljevic S, Bassey BI, Beatty L*, Hassell JA and Daniel JM. Methylation-dependent regulation of hypoxia inducible factor-1 alpha gene expression by the transcription factor Kaiso. (2015) BBA- Gene Regulatory Mechanisms 1849(12):1432-1441

Show All +