Juliet Daniel

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Biography

Dr. Juliet Daniel is a Professor in the Department of Biology at McMaster University. Dr. Daniel received her B.Sc. from Queen’s University (Kingston), her Ph.D. from UBC (Vancouver) and completed postdoctoral fellowships at St. Jude Children’s Research Hospital and Vanderbilt University in Tennessee. At McMaster, Dr. Daniel’s research team focuses on understanding how disruptions in cell-cell adhesion and signaling contribute to cancer initiation and progression. Dr. Daniel is most interested in the aggressive triple negative breast cancer (TNBC) subtype that is associated with poor prognosis due to an absence of specific therapies. Intriguingly, young pre-menopausal women of African ancestry have a higher TNBC prevalence and mortality compared to other ethnicities despite a lower incidence and lifetime risk of breast cancer. Since socio-economic status does not fully explain the racial disparity in TNBC prevalence and mortality, Dr. Daniel's research team seeks to identify unique biomarkers or gene mutations that may explain this racial disparity. Her team will utilize genetic, genomic, molecular and cell biology techniques to analyze TNBC tissues from populations of shared African ancestry (Caribbean and West Africa) to identify genetic risk factors that can be used as biomarkers to diagnose or develop therapies for TNBC patients worldwide.

Areas of Expertise (7)

Breast Cancer Research

Colon Cancer Research

Cadherin-mediated cell adhesion

Cell & Molecular Biology

Developmental Biology

Kaiso and transcription factors

Women in Science and Engineering

Accomplishments (15)

Black Arts and Innovation Expo Trailblazer Award 2016 (professional)

Excelovate and First Book Canada, Toronto, ON

Gordon and Jean Southam Fellowship 2014 (professional)

Association of Commonwealth Universities (ACU) Titular Fellowship, UK

YWCA Hamilton – Woman of Distinction Award 2014

Hamilton, ON

Honorary Inductee International Golden Key Society 2013 (professional)

McMaster University

Nominee, President’s Award of Excellence for Graduate Supervision 2013 (professional)

McMaster University

17th Annual Black History Month Celebration- Actions Speak Louder than Words 2011

Toronto Police Service, Toronto, ON

Outstanding Community Service Award 2011

The Afro-Canadian Caribbean Association of Hamilton & District Inc., ON

Gold Crown of Merit for Cancer Research 2009 (professional)

Barbados National Honor, Barbados

Errol Walton Barrow Award of Excellence 2009

Barbados Ball Canada Aid, Toronto, ON

Collaborative Conference Community Service Award 2008

Collaborative Conference of Barbadian Associations, Barbados

African Canadian Achievement Award of Excellence in Science 2008 (professional)

African Canadian Achievement Awards of Excellence, Toronto, ON

Scientific Achievement Award 2006 (professional)

Barbados American Cancer Association, New York, NY

Professional Achievement Award 2005 (professional)

John C. Holland Black History Month Award, Hamilton, ON

AACR Minority Scholar in Cancer Research Travel Award 2004, 2005 (professional)

American Association for Cancer Research, Orlando, FL

Ontario Premier’s Research Excellence Award (PREA) 2001-2006 (professional)

Ministry of Economic Development and Trade, Toronto, ON

Education (2)

Queen's University: B.Sc. Hons, Life Sciences 1987

University of British Columbia: Ph.D., Microbiology 1993

Affiliations (7)

• Associate Member, Dept. of Oncology, McMaster University
• Associate Member, Farncombe Family Digestive Health Research Institute, McMaster University
• Member, American Association for Cancer Research (AACR)
• Member, Canadian Society for Molecular Biosciences
• Member, American Society for Cell Biology (ASCB)
• Member, American Society for Microbiology
• Co-founder, Academic Women's Success and Mentorship (AWSM) Lecture Series

Links (2)

• McMaster University Juliet M. Daniel
• Daniel Lab Website

Languages (1)

• English

Media Appearances (3)

Breast Cancer Researchers Are Zeroing in On Inventive Solutions To Breast Cancer

Personal Health News  

2015

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IDENTIFICATION OF UNIQUE TRIPLE NEGATIVE BREAST CANCER (TNBC) BIOMARKERS IN WOMEN OF AFRICAN ANCESTRY (WAA

CBCF  

2015

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Targeted Research Helps Change the Breast Cancer Landscape

Market Wired  

2015

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Event Appearances (2)

Think Beyond Love Pink Breast Cancer Awareness

Think Beyond Love Pink Breast Cancer Awareness Campaign  G98.7 FM, The Way We Groove

2016-10-30

Think Beyond Love Pink Breast Cancer Awareness

Think Beyond Love Pink Breast Cancer Awareness Interview  ROGERS TV Daytime, Durham, Ontario

2016-11-01

Research Grants (9)

Identification of unique triple negative breast cancer (TNBC) biomarkers in Women of African Ancestry (WAA)

CBCF 

2015-2018

POZ-ZF transcription factors in signaling and development.

NSERC (Operating) 

2015-2020

Identification of a TNBC Signature in a Unique Cohort of Women of African Ancestry (WAA)

JHCCF (Operating) 

2014-2015

Role of Kaiso in HIF-1α expression and function in hypoxia and tumorigenesis.

JCCF (Operating) 

2011-2012

POZ-ZF transcription factors in cell adhesion and development.

NSERC 

2010-2015

Roles of the bimodal transcription repressor Kaiso in cell proliferation & Wnt signaling.

CIHR (Operating) 

2007-2012

The bimodal transcriptional repressor Kaiso: mechanisms of gene regulation.

CIHR (Operating) 

2004-2007

The catenin p120ctn as an importin for the transcription factor Kaiso: novel regulators of cell adhesion and tumourigenesis?

DOD IDEA Award (Operating) 

2002-2005

Defining the role of Kaiso, a POZ-zinc finger transcription factor and p120ctn- binding protein in cadherin-mediated cell adhesion and signalling.

CIHR (Operating) 

2000-2003

Articles (35)

Kaiso depletion attenuates transforming growth factor-β signaling and metastatic activity of triple negative breast cancer cells.

Oncogenesis

2016-03-21

Bassey-Archibong BI, Kwacien JM, Milosavljevic S, Hallett RM, Rayner LGA, Erb MJ, Crawford-Brown CJ*, Stephenson KB, Bedard P-A, Hassell JA and Daniel JM. Kaiso depletion attenuates transforming growth factor-β signaling and metastatic activity of triple negative breast cancer cells. (2016) NPG-Oncogenesis 5, e208 Published online 21st March 2016

Kaiso, a transcriptional repressor, promotes cell migration and invasion of prostate cancer cells through regulation of miR-31 expression.

Oncotarget

Wang H, Liu W, Black S, Turner O, Daniel JM, Dean-Colomb W, He QP, Davis M and Yates C. 
Kaiso, a transcriptional repressor, promotes cell migration and invasion of prostate cancer cells through regulation of miR-31 expression. (2016) Oncotarget, 7(5): 5677-5689

Methylation-dependent regulation of hypoxia inducible factor-1 alpha gene expression by the transcription factor Kaiso.

BBA- Gene Regulatory Mechanisms

Pierre CC, Longo J*, Hallett RM, Milosavljevic S, Bassey BI, Beatty L*, Hassell JA and Daniel JM. Methylation-dependent regulation of hypoxia inducible factor-1 alpha gene expression by the transcription factor Kaiso. (2015) BBA- Gene Regulatory Mechanisms 1849(12):1432-1441

Kaiso overexpression promotes intestinal inflammation and potentiates intestinal tumorigenesis in ApcMin/+ mice

BBA- Molecular Basis of Disease

Pierre CC, Longo J*, Mavor M*, Milosavljevic S, Chaudhary R, Gilbreath E, Yates C and Daniel JM. Kaiso overexpression promotes intestinal inflammation and potentiates intestinal tumorigenesis in ApcMin/+ mice (2015) BBA- Molecular Basis of Disease 1842(9): 1846-1855

The POZ‐ZF transcription factor Kaiso (ZBTB33) induces inflammation and progenitor cell differentiation in the murine intestine.

PLoS ONE

Chaudhary R, Pierre CC, Nanan K, Wojtal D*, Morone S, Pinelli C, Wood GM, Robine S and Daniel JM. The POZ‐ZF transcription factor Kaiso (ZBTB33) induces inflammation and progenitor cell differentiation in the murine intestine. (2013) PLoS ONE 8(9): e74160.

Kaiso represses the cell cycle gene cyclin D1 via sequence-specific and methyl-CpG-dependent mechanisms.

PLoS ONE

Donaldson NS, Pierre CC, Anstey MI, Robinson SC, Weerawardane S and Daniel JM. Kaiso represses the cell cycle gene cyclin D1 via sequence-specific and methyl-CpG-dependent mechanisms. (2012) PLoS ONE 7(11): e50398.

Nuclear Kaiso Expression is associated with High Grade and Triple-Negative Invasive Breast Cancer.

PLoS ONE

Vermeulen JF, van de Ven RAH, Ercan C, van der Groep P, van der Wall E, Bult P, Christgen M, Lehmann U, Daniel JM, van Diest PJ and Derksen PWB. Nuclear Kaiso Expression is associated with High Grade and Triple-Negative Invasive Breast Cancer. (2012) PLoS ONE 7(5): e37864.

ZBTB33 (Mus musculus).

Transcription Factor Encyclopedia

Nanan KK and Daniel JM.  ZBTB33 (Mus musculus).  (2010) Transcription Factor Encyclopedia. 13 (3)

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Kaiso regulates Znf131-mediated transcriptional activation.

Experimental Cell Research

Donaldson NS, Nordgaard CL, Pierre CC, Kelly KF, Robinson S, Swystun L*, Henriquez R*, Graham M and Daniel JM. Kaiso regulates Znf131-mediated transcriptional activation. (2010) Exp. Cell Res. 316: 1692-1705.

Hypoxia inducible factor (HIF)-2α is required for the development of the catecholaminergic phenotype of sympathoadrenal cells.

Journal of Neurochemistry

Brown ST, Kelly KF, Daniel JM and Nurse CA. Hypoxia inducible factor (HIF)-2α is required for the development of the catecholaminergic phenotype of sympathoadrenal cells. (2009) J. Neurochem. 110: 622-630.

A role for the cleaved cytoplasmic domain of E-cadherin in the nucleus

The Journal of Biological Chemistry

erber EC, Kajita M, Wadlow A, Tobiansky L, Niessen C, Ariga H, Daniel J, Fujita Y. A role for the cleaved cytoplasmic domain of E-cadherin in the nucleus. (2008) J. Biol. Chem. 283:12691-12700.

Nuclear trafficking of the novel POZ-ZF protein Znf131.

Molecular Cell Research

Donaldson NS, Daniel Y*, Kelly KF, Graham M and Daniel JM. Nuclear trafficking of the novel POZ-ZF protein Znf131. (2007) BBA- Mol. Cell Res.1773: 546-555.

Dancing in and out of the nucleus: p120ctn and the transcription factor Kaiso. (2007) BBA- Molecular Cell Research Special issue “The p120-Catenin Protein Family”

Molecular Cell Research Special Issue

Daniel JM. Dancing in and out of the nucleus: p120ctn and the transcription factor Kaiso. (2007) BBA- Molecular Cell Research Special issue “The p120-Catenin Protein Family”. 1773: 59-68. (Guest Co-editor with Dr. Alpha Yap).

POZ for Effect – POZ-ZF Transcription Factors in Cancer and Development

Trends Cell Biology

Kelly KF and Daniel JM. POZ for Effect – POZ-ZF Transcription Factors in Cancer and Development. (2006) Trends Cell Biol. 16: 578-587.

The human enhancer-blocker CTCF interacts with the transcription factor Kaiso.

Journal Biology Chemistry

Defossez PA, Kelly KF, Filion G, Magdinier F, Menoni H, Nordgaard CL, Daniel JM and Gilson E. The human enhancer-blocker CTCF interacts with the transcription factor Kaiso. (2005) J. Biol. Chem. 280:43017-43023.

The catenin p120ctn inhibits Kaiso-mediated Transcriptional Repression of the β-catenin/TCF target gene matrilysin

Experimental Cell Research

Spring CM, Kelly KF, O’Kelly I, Graham M, Crawford HC and Daniel JM. The catenin p120ctn inhibits Kaiso-mediated Transcriptional Repression of the β-catenin/TCF target gene matrilysin. (2005) Exp. Cell Res. 305:253- 265.

Non-Canonical Wnt signals are modulated by the Kaiso transcriptional repressor and p120-catenin

Nature Cell Biology

Kim SW, Park JI, Spring CM, Sater AK, Ji H, Otchere AA, Daniel JM and McCrea PD. Non-Canonical Wnt signals are modulated by the Kaiso transcriptional repressor and p120-catenin. (2004) Nat. Cell Biol. 6: 1212-1220.

Nuclear Import of the BTB/POZ Transcriptional Regulator Kaiso.

Journal of Cell Science

Kelly KF, Otchere AA, Graham M and Daniel JM. Nuclear Import of the BTB/POZ Transcriptional Regulator Kaiso. (2004) J. Cell Sci. 117: 6143-6152.

Regulation of the Rapsyn promoter by Kaiso and δ-catenin.

Journal of Molecular Cell Biology

Rodova M, Kelly KF, VanSaun M, Daniel JM and Werle MJ. Regulation of the Rapsyn promoter by Kaiso and δ-catenin. (2004) Mol. Cell. Biol. 24: 7188-7196.

NLS-dependent nuclear localization of p120ctn is necessary to relieve Kaiso-mediated transcriptional repression.

Journal of Cell Science

Kelly KF, Spring CM, Otchere AA and Daniel JM. NLS-dependent nuclear localization of p120ctn is necessary to relieve Kaiso-mediated transcriptional repression. (2004) J. Cell Sci. 117: 2675-2686.

The p120ctn-binding partner Kaiso is a bi-modal DNA-binding protein that recognizes both a sequence-specific consensus and methylated CpG dinucleotides.

Nucleic Acid Research

Daniel JM, Spring CM, Reynolds AB, Crawford HC and Baig A. The p120ctn-binding partner Kaiso is a bi-modal DNA-binding protein that recognizes both a sequence-specific consensus and methylated CpG dinucleotides. (2002) Nucleic Acids Res. 30: 2911-2919.

Isolation and characterization of XKaiso, a transcriptional repressor that associates with the catenin Xp120ctn in Xenopus laevis

Journal of Biological Chemistry

Kim SW, Fang X, Ji L, Paulson AF, Daniel JM, Ciesiolka M, van Roy F and McCrea PD. Isolation and characterization of XKaiso, a transcriptional repressor that associates with the catenin Xp120ctn in Xenopus laevis. (2002) J. Biol. Chem. 277: 8202-8208.

Monoclonal antibodies to Kaiso, a novel transcription factor and p120ctn-binding protein.

Hybridoma

Daniel JM, Ireton RC and Reynolds AB. Monoclonal antibodies to Kaiso, a novel transcription factor and p120ctn-binding protein. (2001) Hybridoma 20: 159-166.

Selective uncoupling of p120ctn from E-cadherin disrupts strong adhesion.

Journal of Cell Biology

Thoreson MA, Anastasiadis PZ, Daniel JM, Ireton RC, Wheelock MJ, Johnson KR, Hummingbird DK and Reynolds AB. Selective uncoupling of p120ctn from E-cadherin disrupts strong adhesion. (2000) J. Cell Biol. 148: 189-201.

Production and characterization of monoclonal antibodies to ARVCF

Hybridoma

Mariner DJ, Sirotkin H, Daniel JM, Lindman BR, Mernaugh RL, Patten AK, Thoreson MA, Kucherlapati R and Reynolds AB. Production and characterization of monoclonal antibodies to ARVCF. (1999) Hybridoma 18: 343-349.

The catenin p120ctn interacts with Kaiso, a novel BTB/POZ domain zinc finger transcription factor

Journal of Molecular Biology

Daniel JM and Reynolds AB. The catenin p120ctn interacts with Kaiso, a novel BTB/POZ domain zinc finger transcription factor. (1999) Mol. Cell. Biol. 19: 3614-3623.

Tyrosine phosphorylation and cadherin/catenin function.

Bioessays

Daniel JM and Reynolds AB. Tyrosine phosphorylation and cadherin/catenin function. (1997) Bioessays 19: 883-891.

The gene encoding p120cas, a novel catenin, localizes on human chromosome 11q11 (CTNND) and mouse chromosome 2 (Catns)

Genomics

Reynolds AB, Jenkins NA, Gilbert DJ, Copeland NG, Shapiro DN, Wu J and Daniel JM. The gene encoding p120cas, a novel catenin, localizes on human chromosome 11q11 (CTNND) and mouse chromosome 2 (Catns). (1996) Genomics 31: 127-129.

The novel catenin p120cas binds classical cadherins and induces an unusual morphological phenotype in NIH 3T3 fibroblasts

Experimental Cell Research

Reynolds AB, Zhang Z, Wu J, Daniel JM and Mo Y-Y. The novel catenin p120cas binds classical cadherins and induces an unusual morphological phenotype in NIH 3T3 fibroblasts. (1996) Exp. Cell Res. 225: 328-337.

The tyrosine kinase substrate p120cas binds directly to E-cadherin but not APC or α-catenin

Journal of Molecular Cell Biology

Daniel JM and Reynolds AB. The tyrosine kinase substrate p120cas binds directly to E-cadherin but not APC or α-catenin. (1995) Mol. Cell. Biol. 15: 4819-4824.

Identification of a new catenin: The tyrosine kinase substrate p120cas associates with E-cadherin complexes

Journal of Molecular Cell Biology

Reynolds AB, Daniel J, McCrea PD, Wheelock MT, Wu J and Zhang Z. Identification of a new catenin: The tyrosine kinase substrate p120cas associates with E-cadherin complexes. (1994) Mol. Cell. Biol. 14: 8333-8342.

Isolation of two novel ras genes in Dictyostelium discoideum; evidence for a complex, developmentally regulated ras gene subfamily.

Oncogene

Daniel J, Bush J, Cardelli J, Spiegelman GB and Weeks G. Isolation of two novel ras genes in Dictyostelium discoideum; evidence for a complex, developmentally regulated ras gene subfamily. (1994) Oncogene 9: 501-508.

Cloning and characterization of 5 novel Dictyostelium discoideum rab-related genes.

Gene

Bush J, Franek K, Daniel J, Spiegelman GB, Weeks G and Cardelli J. Cloning and characterization of 5 novel Dictyostelium discoideum rab-related genes. (1993) Gene 136: 55-60.

Characterization of a third ras gene, rasB, that is expressed throughout the growth and development of Dictyostelium discoideum.

Oncogene

Daniel J, Spiegelman GB and Weeks G. Characterization of a third ras gene, rasB, that is expressed throughout the growth and development of Dictyostelium discoideum. (1993) Oncogene 8: 1041-1047.

A Dictyostelium morphogen that is essential for stalk cell formation is generated by a subpopulation of pre-stalk cells

Development

Kwong L, Xie Y, Daniel J, Robbins SM and Weeks G. A Dictyostelium morphogen that is essential for stalk cell formation is generated by a subpopulation of pre-stalk cells. (1990) Development 110: 303-310.