Juliet Daniel
Professor of Biology McMaster University
- Hamilton ON
Dr. Daniel is a Cancer Biologist with expertise in breast cancer, racial disparities in cancer, and diversity issues in higher education.
Media
Social
Biography
Areas of Expertise
Accomplishments
Black Arts and Innovation Expo Trailblazer Award 2016
Excelovate and First Book Canada, Toronto, ON
Gordon and Jean Southam Fellowship 2014
Association of Commonwealth Universities (ACU) Titular Fellowship, UK
YWCA Hamilton – Woman of Distinction Award 2014
Hamilton, ON
Honorary Inductee International Golden Key Society 2013
McMaster University
Nominee, President’s Award of Excellence for Graduate Supervision 2013
McMaster University
17th Annual Black History Month Celebration- Actions Speak Louder than Words 2011
Toronto Police Service, Toronto, ON
Outstanding Community Service Award 2011
The Afro-Canadian Caribbean Association of Hamilton & District Inc., ON
Gold Crown of Merit for Cancer Research 2009
Barbados National Honor, Barbados
Errol Walton Barrow Award of Excellence 2009
Barbados Ball Canada Aid, Toronto, ON
Collaborative Conference Community Service Award 2008
Collaborative Conference of Barbadian Associations, Barbados
African Canadian Achievement Award of Excellence in Science 2008
African Canadian Achievement Awards of Excellence, Toronto, ON
Scientific Achievement Award 2006
Barbados American Cancer Association, New York, NY
Professional Achievement Award 2005
John C. Holland Black History Month Award, Hamilton, ON
AACR Minority Scholar in Cancer Research Travel Award 2004, 2005
American Association for Cancer Research, Orlando, FL
Ontario Premier’s Research Excellence Award (PREA) 2001-2006
Ministry of Economic Development and Trade, Toronto, ON
Education
Queen's University
B.Sc. Hons
Life Sciences
1987
University of British Columbia
Ph.D.
Microbiology
1993
Affiliations
- Associate Member, Dept. of Oncology, McMaster University
- Associate Member, Farncombe Family Digestive Health Research Institute, McMaster University
- Member, American Association for Cancer Research (AACR)
- Member, Canadian Society for Molecular Biosciences
- Member, American Society for Cell Biology (ASCB)
- Member, American Society for Microbiology
- Co-founder, Academic Women's Success and Mentorship (AWSM) Lecture Series
Languages
- English
Media Appearances
Breast Cancer Researchers Are Zeroing in On Inventive Solutions To Breast Cancer
Personal Health News
2015
IDENTIFICATION OF UNIQUE TRIPLE NEGATIVE BREAST CANCER (TNBC) BIOMARKERS IN WOMEN OF AFRICAN ANCESTRY (WAA
CBCF
2015
Event Appearances
Think Beyond Love Pink Breast Cancer Awareness
Think Beyond Love Pink Breast Cancer Awareness Campaign G98.7 FM, The Way We Groove
2016-10-30
Think Beyond Love Pink Breast Cancer Awareness
Think Beyond Love Pink Breast Cancer Awareness Interview ROGERS TV Daytime, Durham, Ontario
2016-11-01
Research Grants
Identification of unique triple negative breast cancer (TNBC) biomarkers in Women of African Ancestry (WAA)
CBCF
2015-2018
POZ-ZF transcription factors in signaling and development.
NSERC (Operating)
2015-2020
Identification of a TNBC Signature in a Unique Cohort of Women of African Ancestry (WAA)
JHCCF (Operating)
2014-2015
Role of Kaiso in HIF-1α expression and function in hypoxia and tumorigenesis.
JCCF (Operating)
2011-2012
POZ-ZF transcription factors in cell adhesion and development.
NSERC
2010-2015
Roles of the bimodal transcription repressor Kaiso in cell proliferation & Wnt signaling.
CIHR (Operating)
2007-2012
The bimodal transcriptional repressor Kaiso: mechanisms of gene regulation.
CIHR (Operating)
2004-2007
The catenin p120ctn as an importin for the transcription factor Kaiso: novel regulators of cell adhesion and tumourigenesis?
DOD IDEA Award (Operating)
2002-2005
Defining the role of Kaiso, a POZ-zinc finger transcription factor and p120ctn- binding protein in cadherin-mediated cell adhesion and signalling.
CIHR (Operating)
2000-2003
Articles
Kaiso depletion attenuates transforming growth factor-β signaling and metastatic activity of triple negative breast cancer cells.
Oncogenesis2016-03-21
Bassey-Archibong BI, Kwacien JM, Milosavljevic S, Hallett RM, Rayner LGA, Erb MJ, Crawford-Brown CJ*, Stephenson KB, Bedard P-A, Hassell JA and Daniel JM. Kaiso depletion attenuates transforming growth factor-β signaling and metastatic activity of triple negative breast cancer cells. (2016) NPG-Oncogenesis 5, e208 Published online 21st March 2016
Kaiso, a transcriptional repressor, promotes cell migration and invasion of prostate cancer cells through regulation of miR-31 expression.
OncotargetWang H, Liu W, Black S, Turner O, Daniel JM, Dean-Colomb W, He QP, Davis M and Yates C. Kaiso, a transcriptional repressor, promotes cell migration and invasion of prostate cancer cells through regulation of miR-31 expression. (2016) Oncotarget, 7(5): 5677-5689
Methylation-dependent regulation of hypoxia inducible factor-1 alpha gene expression by the transcription factor Kaiso.
BBA- Gene Regulatory MechanismsPierre CC, Longo J*, Hallett RM, Milosavljevic S, Bassey BI, Beatty L*, Hassell JA and Daniel JM. Methylation-dependent regulation of hypoxia inducible factor-1 alpha gene expression by the transcription factor Kaiso. (2015) BBA- Gene Regulatory Mechanisms 1849(12):1432-1441
Kaiso overexpression promotes intestinal inflammation and potentiates intestinal tumorigenesis in ApcMin/+ mice
BBA- Molecular Basis of DiseasePierre CC, Longo J*, Mavor M*, Milosavljevic S, Chaudhary R, Gilbreath E, Yates C and Daniel JM. Kaiso overexpression promotes intestinal inflammation and potentiates intestinal tumorigenesis in ApcMin/+ mice (2015) BBA- Molecular Basis of Disease 1842(9): 1846-1855
The POZ‐ZF transcription factor Kaiso (ZBTB33) induces inflammation and progenitor cell differentiation in the murine intestine.
PLoS ONEChaudhary R, Pierre CC, Nanan K, Wojtal D*, Morone S, Pinelli C, Wood GM, Robine S and Daniel JM. The POZ‐ZF transcription factor Kaiso (ZBTB33) induces inflammation and progenitor cell differentiation in the murine intestine. (2013) PLoS ONE 8(9): e74160.
Kaiso represses the cell cycle gene cyclin D1 via sequence-specific and methyl-CpG-dependent mechanisms.
PLoS ONEDonaldson NS, Pierre CC, Anstey MI, Robinson SC, Weerawardane S and Daniel JM. Kaiso represses the cell cycle gene cyclin D1 via sequence-specific and methyl-CpG-dependent mechanisms. (2012) PLoS ONE 7(11): e50398.
Nuclear Kaiso Expression is associated with High Grade and Triple-Negative Invasive Breast Cancer.
PLoS ONEVermeulen JF, van de Ven RAH, Ercan C, van der Groep P, van der Wall E, Bult P, Christgen M, Lehmann U, Daniel JM, van Diest PJ and Derksen PWB. Nuclear Kaiso Expression is associated with High Grade and Triple-Negative Invasive Breast Cancer. (2012) PLoS ONE 7(5): e37864.
ZBTB33 (Mus musculus).
Transcription Factor EncyclopediaNanan KK and Daniel JM. ZBTB33 (Mus musculus). (2010) Transcription Factor Encyclopedia. 13 (3)
Kaiso regulates Znf131-mediated transcriptional activation.
Experimental Cell ResearchDonaldson NS, Nordgaard CL, Pierre CC, Kelly KF, Robinson S, Swystun L*, Henriquez R*, Graham M and Daniel JM. Kaiso regulates Znf131-mediated transcriptional activation. (2010) Exp. Cell Res. 316: 1692-1705.
Hypoxia inducible factor (HIF)-2α is required for the development of the catecholaminergic phenotype of sympathoadrenal cells.
Journal of NeurochemistryBrown ST, Kelly KF, Daniel JM and Nurse CA. Hypoxia inducible factor (HIF)-2α is required for the development of the catecholaminergic phenotype of sympathoadrenal cells. (2009) J. Neurochem. 110: 622-630.
A role for the cleaved cytoplasmic domain of E-cadherin in the nucleus
The Journal of Biological Chemistryerber EC, Kajita M, Wadlow A, Tobiansky L, Niessen C, Ariga H, Daniel J, Fujita Y. A role for the cleaved cytoplasmic domain of E-cadherin in the nucleus. (2008) J. Biol. Chem. 283:12691-12700.
Nuclear trafficking of the novel POZ-ZF protein Znf131.
Molecular Cell ResearchDonaldson NS, Daniel Y*, Kelly KF, Graham M and Daniel JM. Nuclear trafficking of the novel POZ-ZF protein Znf131. (2007) BBA- Mol. Cell Res.1773: 546-555.
Dancing in and out of the nucleus: p120ctn and the transcription factor Kaiso. (2007) BBA- Molecular Cell Research Special issue “The p120-Catenin Protein Family”
Molecular Cell Research Special IssueDaniel JM. Dancing in and out of the nucleus: p120ctn and the transcription factor Kaiso. (2007) BBA- Molecular Cell Research Special issue “The p120-Catenin Protein Family”. 1773: 59-68. (Guest Co-editor with Dr. Alpha Yap).
POZ for Effect – POZ-ZF Transcription Factors in Cancer and Development
Trends Cell BiologyKelly KF and Daniel JM. POZ for Effect – POZ-ZF Transcription Factors in Cancer and Development. (2006) Trends Cell Biol. 16: 578-587.
The human enhancer-blocker CTCF interacts with the transcription factor Kaiso.
Journal Biology ChemistryDefossez PA, Kelly KF, Filion G, Magdinier F, Menoni H, Nordgaard CL, Daniel JM and Gilson E. The human enhancer-blocker CTCF interacts with the transcription factor Kaiso. (2005) J. Biol. Chem. 280:43017-43023.
The catenin p120ctn inhibits Kaiso-mediated Transcriptional Repression of the β-catenin/TCF target gene matrilysin
Experimental Cell ResearchSpring CM, Kelly KF, O’Kelly I, Graham M, Crawford HC and Daniel JM. The catenin p120ctn inhibits Kaiso-mediated Transcriptional Repression of the β-catenin/TCF target gene matrilysin. (2005) Exp. Cell Res. 305:253- 265.
Non-Canonical Wnt signals are modulated by the Kaiso transcriptional repressor and p120-catenin
Nature Cell BiologyKim SW, Park JI, Spring CM, Sater AK, Ji H, Otchere AA, Daniel JM and McCrea PD. Non-Canonical Wnt signals are modulated by the Kaiso transcriptional repressor and p120-catenin. (2004) Nat. Cell Biol. 6: 1212-1220.
Nuclear Import of the BTB/POZ Transcriptional Regulator Kaiso.
Journal of Cell ScienceKelly KF, Otchere AA, Graham M and Daniel JM. Nuclear Import of the BTB/POZ Transcriptional Regulator Kaiso. (2004) J. Cell Sci. 117: 6143-6152.
Regulation of the Rapsyn promoter by Kaiso and δ-catenin.
Journal of Molecular Cell BiologyRodova M, Kelly KF, VanSaun M, Daniel JM and Werle MJ. Regulation of the Rapsyn promoter by Kaiso and δ-catenin. (2004) Mol. Cell. Biol. 24: 7188-7196.
NLS-dependent nuclear localization of p120ctn is necessary to relieve Kaiso-mediated transcriptional repression.
Journal of Cell ScienceKelly KF, Spring CM, Otchere AA and Daniel JM. NLS-dependent nuclear localization of p120ctn is necessary to relieve Kaiso-mediated transcriptional repression. (2004) J. Cell Sci. 117: 2675-2686.
The p120ctn-binding partner Kaiso is a bi-modal DNA-binding protein that recognizes both a sequence-specific consensus and methylated CpG dinucleotides.
Nucleic Acid ResearchDaniel JM, Spring CM, Reynolds AB, Crawford HC and Baig A. The p120ctn-binding partner Kaiso is a bi-modal DNA-binding protein that recognizes both a sequence-specific consensus and methylated CpG dinucleotides. (2002) Nucleic Acids Res. 30: 2911-2919.
Isolation and characterization of XKaiso, a transcriptional repressor that associates with the catenin Xp120ctn in Xenopus laevis
Journal of Biological ChemistryKim SW, Fang X, Ji L, Paulson AF, Daniel JM, Ciesiolka M, van Roy F and McCrea PD. Isolation and characterization of XKaiso, a transcriptional repressor that associates with the catenin Xp120ctn in Xenopus laevis. (2002) J. Biol. Chem. 277: 8202-8208.
Monoclonal antibodies to Kaiso, a novel transcription factor and p120ctn-binding protein.
HybridomaDaniel JM, Ireton RC and Reynolds AB. Monoclonal antibodies to Kaiso, a novel transcription factor and p120ctn-binding protein. (2001) Hybridoma 20: 159-166.
Selective uncoupling of p120ctn from E-cadherin disrupts strong adhesion.
Journal of Cell BiologyThoreson MA, Anastasiadis PZ, Daniel JM, Ireton RC, Wheelock MJ, Johnson KR, Hummingbird DK and Reynolds AB. Selective uncoupling of p120ctn from E-cadherin disrupts strong adhesion. (2000) J. Cell Biol. 148: 189-201.
Production and characterization of monoclonal antibodies to ARVCF
HybridomaMariner DJ, Sirotkin H, Daniel JM, Lindman BR, Mernaugh RL, Patten AK, Thoreson MA, Kucherlapati R and Reynolds AB. Production and characterization of monoclonal antibodies to ARVCF. (1999) Hybridoma 18: 343-349.
The catenin p120ctn interacts with Kaiso, a novel BTB/POZ domain zinc finger transcription factor
Journal of Molecular BiologyDaniel JM and Reynolds AB. The catenin p120ctn interacts with Kaiso, a novel BTB/POZ domain zinc finger transcription factor. (1999) Mol. Cell. Biol. 19: 3614-3623.
Tyrosine phosphorylation and cadherin/catenin function.
BioessaysDaniel JM and Reynolds AB. Tyrosine phosphorylation and cadherin/catenin function. (1997) Bioessays 19: 883-891.
The gene encoding p120cas, a novel catenin, localizes on human chromosome 11q11 (CTNND) and mouse chromosome 2 (Catns)
GenomicsReynolds AB, Jenkins NA, Gilbert DJ, Copeland NG, Shapiro DN, Wu J and Daniel JM. The gene encoding p120cas, a novel catenin, localizes on human chromosome 11q11 (CTNND) and mouse chromosome 2 (Catns). (1996) Genomics 31: 127-129.
The novel catenin p120cas binds classical cadherins and induces an unusual morphological phenotype in NIH 3T3 fibroblasts
Experimental Cell ResearchReynolds AB, Zhang Z, Wu J, Daniel JM and Mo Y-Y. The novel catenin p120cas binds classical cadherins and induces an unusual morphological phenotype in NIH 3T3 fibroblasts. (1996) Exp. Cell Res. 225: 328-337.
The tyrosine kinase substrate p120cas binds directly to E-cadherin but not APC or α-catenin
Journal of Molecular Cell BiologyDaniel JM and Reynolds AB. The tyrosine kinase substrate p120cas binds directly to E-cadherin but not APC or α-catenin. (1995) Mol. Cell. Biol. 15: 4819-4824.
Identification of a new catenin: The tyrosine kinase substrate p120cas associates with E-cadherin complexes
Journal of Molecular Cell BiologyReynolds AB, Daniel J, McCrea PD, Wheelock MT, Wu J and Zhang Z. Identification of a new catenin: The tyrosine kinase substrate p120cas associates with E-cadherin complexes. (1994) Mol. Cell. Biol. 14: 8333-8342.
Isolation of two novel ras genes in Dictyostelium discoideum; evidence for a complex, developmentally regulated ras gene subfamily.
OncogeneDaniel J, Bush J, Cardelli J, Spiegelman GB and Weeks G. Isolation of two novel ras genes in Dictyostelium discoideum; evidence for a complex, developmentally regulated ras gene subfamily. (1994) Oncogene 9: 501-508.
Cloning and characterization of 5 novel Dictyostelium discoideum rab-related genes.
GeneBush J, Franek K, Daniel J, Spiegelman GB, Weeks G and Cardelli J. Cloning and characterization of 5 novel Dictyostelium discoideum rab-related genes. (1993) Gene 136: 55-60.
Characterization of a third ras gene, rasB, that is expressed throughout the growth and development of Dictyostelium discoideum.
OncogeneDaniel J, Spiegelman GB and Weeks G. Characterization of a third ras gene, rasB, that is expressed throughout the growth and development of Dictyostelium discoideum. (1993) Oncogene 8: 1041-1047.
A Dictyostelium morphogen that is essential for stalk cell formation is generated by a subpopulation of pre-stalk cells
DevelopmentKwong L, Xie Y, Daniel J, Robbins SM and Weeks G. A Dictyostelium morphogen that is essential for stalk cell formation is generated by a subpopulation of pre-stalk cells. (1990) Development 110: 303-310.
