Justin Martello, M.D.

Parkinson's and Movement Disorders Director ChristianaCare

  • Wilmington DE

Dr. Martello, Delaware's only Parkinson's and movement disorders specialist, has established a comprehensive Parkinson's disease program.

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First in Delaware to Offer MR-Guided Ultrasound for Treatment of Essential and Parkinson’s Tremor

Revolutionary technology gives patients immediate relief from debilitating tremors without the need for invasive surgery. ChristianaCare is the first health care provider in Delaware to offer FDA-approved focused ultrasound treatment for people suffering from essential tremor and Parkinson’s disease. The new option – called MR-guided focused ultrasound – uses sound wave energy to destroy precise areas of brain tissue that is the source of the tremor. No surgical incision or anesthesia is necessary, and many patients experience immediate and significant reduction in tremors, which can make daily activities challenging. Dr. Martello explains that the procedure involves the use of high-frequency sound waves directed with pinpoint precision by magnetic resonance imaging to ablate, or burn, the focal point deep within the brain that is causing tremors. “This minimally invasive technology dramatically improves the lives of patients with essential tremor and tremor-dominant Parkinson’s who haven’t fully responded to traditional treatments,’’ said Justin Martello, M.D., director of the Parkinson’s and Movement Disorders Programs, and Focused Ultrasound Program at ChristianaCare. What is tremor? Tremor is a neurological condition that includes involuntary shaking or trembling movements in one or more parts of the body. It most commonly affects the hands and can make daily tasks such as writing, eating and using a computer or phone extremely difficult. Tremor affects approximately 1% of the population overall and 5% of adults age 60+. It is expected to increasingly impact Delawareans as the state’s population ages. Essential tremor is the most common type of tremor. It can occur at any age but is most common in older adults. Tremor is also the most well-known symptom of Parkinson’s disease. An estimated 1.5 million Americans suffer from Parkinson’s disease, a progressive neurodegenerative disease that affects movement and can also affect speech, balance and cognitive function. A newer, better option for patients who don’t respond to medications The procedure of MR-guided focused ultrasound involves the use of high-frequency sound waves directed with pinpoint precision by magnetic resonance imaging to ablate, or burn, the focal point deep within the brain that is causing tremors. Patients are fitted with a frame affixed to a specialized helmet that combines the focused energy of more than 1,000 high-frequency sonic beams directed through the skull. The treatment does not require cutting through the skull, or radiation, as in gamma knife technology. “Today, there are basically three options for managing tremor,” said Pulak Ray, M.D., of Delaware Neurosurgical Group and associate director of the Focused Ultrasound program. “The first is medication, which is effective and affordable for many patients, but its effectiveness tends to diminish over time. The second is deep-brain stimulation, which is the most invasive and costly treatment option. The newest is MR-guided ultrasound, which tends to be the preferable option for most patients who do not respond well to medication, because it is a simple, non-invasive outpatient procedure that is highly effective, safe and produces instant results.” Benefits of MR-guided Focused Ultrasound MR-guided focused ultrasound reduces tremor immediately, with shorter recovery time, lower risk of side effects and lower associated health care expenses compared to surgical alternatives. This treatment dramatically improves patient experience and quality of life for people with Parkinson’s disease or essential tremor. For many patients, MR-guided ultrasound reduces their dependence on caregivers to assist with activities of daily living. Candidates must first undergo a CT scan to ensure a skull density sufficiently thick to accommodate the procedure. The patient is awake during the procedure and situated within an MRI machine for real-time imaging of the brain. The physician tests the precise location by heating the area, then ensuring the patient is able to control tremors by tracing lines on a spirograph. At that point, the physician then permanently ablates the focal point, usually a sphere a few millimeters in length. “Our team is very excited to bring this technology to Delaware and to open up access to potentially life-changing treatment that until now has required long wait times and significant travel for patients,” said Kim Gannon, M.D., Ph.D., medical director of the comprehensive stroke program and physician executive of Neuroscience Service Line at ChristianaCare. “Many tremor patients have suffered for years or even decades with this debilitating and progressive condition and helping them live a more active and independent lifestyle is extremely rewarding.” MR-guided focused ultrasound is covered by Medicare and most insurance plans.

Justin Martello, M.D.

Biography

Dr. Martello, is a board certified neurologist specializing in movement disorders and Parkinson’s Disease at ChristianaCare. He has developed Delaware's first and only comprehensive Parkinson's disease program.

Areas of Expertise

Quality Improvement
Parkinson's Disease
Neurology
Movement Disorders

Education

University of Maryland School of Medicine

M.D.

2011

Media Appearances

Does Bipolar Disorder Raise Risk of Parkinson's?

WebMD  online

2019-05-23

Those with bipolar who developed Parkinson's were nine years younger -- average age 64 -- than others who also developed Parkinson's, the study found.

"When you say there's seven times the risk, it gets scary. But it's still very few [bipolar] patients who get Parkinson's," said Dr. Justin Martello, who reviewed the findings. He's a neurologist specializing in movement disorders and Parkinson's disease at Christiana Care Health System in Wilmington, Del.

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Martello pointed out that while the study was large, it was limited by including only people in Taiwan.

"We don't know how this would apply more globally or broadly," Martello said. "I think it's more interesting for physicians to know this and be more aware of the association."

The study was published online May 22 in the journal Neurology.

Pontone, who cowrote an accompanying editorial, and Martello said scientists have many theories -- still unproven -- about how bipolar disorder might be connected to the development of Parkinson's.

"A depressive or manic episode may do something to the brain that renders it more vulnerable" to Parkinson's over time, Pontone said.

And Martello noted that many medications used to treat bipolar disorder can trigger Parkinson's-like symptoms.

Many experts think Parkinson's is active years or decades before movement problems show up, and mood disorders such as bipolar may actually be an early symptom of Parkinson's, Pontone and Martello said.

Much more research is still needed, they agreed.

"We definitely need to look more at a global population," Martello said. "The researchers here did follow patients for 10 years, but it needs to be extended longer to see how many of these patients convert to Parkinson's down the road."

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Neurosurgery in Parkinson Disease: A Brief History and Look Forward

Neurology Advisor  online

2018-04-11

Although DBS, similar to all PD therapies, cannot cure, modify, or slow progression of the disease, some recent research suggests that the symptom alleviation and quality-of-life improvement it provides might lead to mild improvements in longevity, noted Justin Martello, MD, a PD and movement disorders specialist from Christiana Care Neurology Specialists in Newark, Delaware.

“It does improve function, so it may improve morbidity over time,” Dr Martello told Neurology Advisor. “It can improve a patient’s life so they can be more active, and that can infer a longer life.”

Most research is therefore focusing on comparing different DBS targets, refining DBS methods and tools, and exploring other interventions only in early phase or preclinical trials.

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Selected Papers and Publications

Physical Therapist Management of Parkinson Disease: A Clinical Practice Guideline From the American Physical Therapy Association

American Physical Therapy Association

2022-04-01

A clinical practice guideline on Parkinson disease was developed by an American Physical Therapy Association volunteer guideline development group that consisted of physical therapists and a neurologist. The guideline was based on systematic reviews of current scientific and clinical information and accepted approaches for management of Parkinson disease.

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Dopaminergic Therapy for Motor Symptoms in Early Parkinson Disease Practice Guideline Summary: A Report of the AAN Guideline Subcommittee

Neurology

2021-11-16

A review of the current evidence on the options available for initiating dopaminergic treatment of motor symptoms in early-stage Parkinson disease with recommendations to clinicians.

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Quality Improvement in Neurology: 2020 Parkinson Disease Quality Measurement Set Update

Neurology

2021-08-03

The AAN initiates review of quality measures periodically to determine whether an update is warranted. Through implementation of the PD quality measures in the Axon Registrya nd in the Medicare Quality Payment Program (QPP) Merit-Based Incentive Payment System (MIPS) program, the AAN determined that an update was necessary to improve measure specifications for the PD quality Measurement Set.

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External Service & Affiliations

  • American Board of Psychiatry and Neurology