
Karelle Aiken
Associate Professor Georgia Southern University
Biography
Areas of Expertise
Education
University of New Hampshire
Ph.D.
2005
Williams College
B.S.
2000
Articles
A simple and effective 1,2,3-triazole based "turn-on" fluorescence sensor for the detection of anions
New J. of Chem.Ghosh, Debanjana; Rhodes, Shannon; Hawkins, Karena; Winder, Domonique; Atkinson, Austin; Ming, Weihua; Padgett, Clifford; Orvis, Jeffery; Aiken, Karelle; Landge, Shainaz.
2015
A novel and effective 1,2,3-triazole based fluorescence chemosensor has been synthesized for the specific detection of anions in homogeneous medium. Notably, the molecule, synthesized in one step using “Click chemistry”, is a simple 1,4-diaryl-1,2,3-triazole, containing a phenol moiety.
Hydration of 5-Oxo-1-Alkynes by a One-Pot Oxy-Iodination/Reduction Sequence: Synthesis of Methyl Ketones with Anchimeric Assistance
Curr. Org. Syn.Trossarello, Julia; Egunjobi, Adegboyega; Morgan, Whitney J.; Ahamed, Rayaj; Aiken, Karelle S.
2014
Methyl ketone derivatives can be accessed from 5-oxo-1-alkynes in an iodine-initiated hydration of the terminal alkynes. Use of molecular iodine in this manner is novel, inexpensive and a greener alternative to the traditional use of transition metal catalysts. Herein, we report the results of a methodology study which sheds light on the underlying mechanism of this new, metal-free reaction. Our findings indicate that the hydration of the alkyne proceeds via an important anchimeric assistance in which the neighboring keto group participates with a 5-exo-dig cyclization.
Solid-Phase Organic Synthesis and Combinatorial Chemistry: A Laboratory Preparation of Oligopeptides
J. Chem. Ed.Truran, George A.; Aiken, Karelle S.; Fleming, Thomas R.; Webb, Peter J.; Markgraf, J. Hodge
2002
The principles and practice of solid-phase organic synthesis and combinatorial chemistry are utilized in a laboratory preparation of oligopeptides. A parallel synthesis scheme is used to generate a series of tripeptides. A divergent synthesis scheme is used to prepare two pentapeptides, one of which is leucine enkephalin, a neurotransmitter known to be an analgesic agent.