Kayla N. Green received her BS degree from Tarleton State University in 2003. In 2007, she obtained her Ph.D. in Inorganic Chemistry from Texas A&M University under the direction of Marcetta Y. Darensbourg where she studied immobilized biomimetic complexes of metalloenzymes such as Acetyl CoA Synthase. While there she was honored with the U.S. Senator Phil Gramm Doctoral Fellowship Award (2007) and a Chemistry Biology Interface – NIH Training Grant (2004). In 2008 she began her postdoctoral work at UT Southwestern Medical Center, Advanced Imaging Research Center for A. Dean Sherry. Her research focused on the synthesis of lanthanide complexes for molecular imaging using novel NMR techniques and the development of computational methods for the evaluation of these complexes. Kayla joined the faculty at TCU in the Fall of 2010.
Areas of Expertise (6)
Chemistry of Alzheimer's Disease
Organic and Solid-phase Syntheses
Neurobiology of Aging
Applications at the Interface of Chemistry and Biology
U.S. Senator Phil Gramm Doctoral Fellowship Award (professional)
Chemistry Biology Interface
Texas A&M University: PhD, Chemistry
Tarleton State University: BS, Chemistry
- Director, The Green Research Group
Md Tanvir Hasan, Roberto Gonzalez-Rodriguez, Conor Ryan, Kristof Pota, Kayla Green, Jeffery L Coffer, Anton V Naumov
In this work, we utilize a bottom-up approach to synthesize nitrogen self-doped graphene quantum dots (NGQDs) from a single glucosamine precursor via an eco-friendly microwave-assisted hydrothermal method. Structural and optical properties of as-produced NGQDs are further modified using controlled ozone treatment. Ozone-treated NGQDs (Oz-NGQDs) are reduced in size to 5.5 nm with clear changes in the lattice structure and ID/IG Raman ratios due to the introduction/alteration of oxygen-containing functional groups detected by Fourier-transform infrared (FTIR) spectrometer and further verified by energy dispersive X-ray spectroscopy (EDX) showing increased atomic/weight percentage of oxygen atoms.
EuDOTA‐glycine derivatives have been explored as alternatives to typical gadolinium‐containing complexes for MRI agents used in diagnostic imaging. Different imaging modalities can be accessed (T1 or PARACEST) dependent on the oxidation state of the europium ion. Throughout the past 30 years, there have been significant manipulations and additions made to the DOTA scaffold; yet, characterizations related to electrochemistry and structure determined through XRD analysis have not been fully analyzed. In this work, electrochemical analysis using cyclic voltammetry was carried out on EuDOTA derivatives, including the free ligand DOTAGly4 (4) and the complexes.
Samantha M. BrewerKevin R. WilsonDonald G. JonesEric W. ReinheimerStephen J. ArchibaldTimothy J. PriorMegan A. AyalaAlexandria L. FosterTimothy J. Hubin*Kayla N. Green
Macrocyclic ligands have been explored extensively as scaffolds for transition metal catalysts for oxygen and hydrogen atom transfer reactions. C–C reactions facilitated using earth abundant metals bound to macrocyclic ligands have not been well-understood but could be a green alternative to replacing the current expensive and toxic precious metal systems most commonly used for these processes.
Nicotinamides are a class of compounds with a wide variety of applications, from use as antimicrobial agents to inhibitors of biological processes. These compounds are also cofactors, which are necessary components of metabolic processes. Structural modification gives rise to the activities observed. Similarly, 1,3,4-thiadiazoles have been shown to possess antioxidant, antimicrobial, or anti-inflammatory biological activity. To take advantage of each of the inherent characteristics of the two aforementioned functional groups, 2-nicotinamido-1,3,4-thiadiazole, C 8 H 6 N 4 OS, was synthesized. Since defining chemical connectivity is paramount in understanding biological activity, in this report, the structural characterization of 2-nicotinamido-1,3,4-thiadiazole has been carried out using X-ray crystallographic methods. The NMR-derived assignments were made possible by utilizing one- (1D) and two-dimensional (2D) NMR techniques. In addition, UV–Visible and IR spectroscopies, and elemental analysis were used to fully characterize the product synthesized by the one-step reaction between nicotinoyl chloride hydrochloride and 2-amino-1,3,4-thiadiazole. Computational parameters related to blood–brain barrier permeability are also presented.
Early detection is a key to successful treatment of most diseases, and is particularly imperative for the diagnosis and treatment of many types of cancer. The most common techniques utilized are imaging modalities such as Magnetic Resonance Imaging (MRI), Positron Emission Topography (PET), and Computed Topography (CT) and are optimal for understanding the physical structure of the disease but can only be performed once every four to six weeks due to the use of imaging agents and overall cost. With this in mind, the development of "point of care" techniques, such as biosensors, which evaluate the stage of disease and/or efficacy of treatment in the clinician's office and do so in a timely manner, would revolutionize treatment protocols.1 As a means to exploring ferrocene based biosensors for the detection of biologically relevant molecules2, methods were developed to produce ferrocene-biotin bio-conjugates described herein. This report will focus on a biotin-ferrocene-cysteine system that can be immobilized on a gold surface.