Kayla Green
Professor | Texas Christian University
Fort Worth, TX, UNITED STATES
Chemistry, treatment of oxidative stress (neurodegeneration, Alzheimer's). History of Chemistry (gas, atomic bomb).
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Biography
Dr. Kayla N. Green is a native Texan, born and intellectually raised in the Lone Star State. Dr. Green obtained a Ph.D. in Inorganic Chemistry under the direction of Marcetta Darensbourg at Texas A&M University in 2007 studying resin bound synthetic models of Acetyl CoA Synthase and Hydrogenase enzymes. Her interests in applied inorganic chemistry led her to the Advanced Imaging Center where she completed post-doctoral studies under the direction of Dr. Dean Sherry at the UT Southwestern Medical Center in Dallas. In 2010, Dr. Green started her independent career at Texas Christian University in Fort Worth, and was promoted to the rank of associate professor in 2016 and full professor in 2022. Her research team focuses on the development of small molecules as therapeutics for diseases caused by oxidative stress, novel catalysts for challenging hydrocarbon transformations, and electrochemical biosensors. Her work has been supported by the National Institutes of Health, the Robert A. Welch Foundation, and ACS Petroleum Research Fund.
Areas of Expertise (8)
Oxidative Stress
Alzheimer's Disease
Parkinson's Disease
Cataracts and Macular Degeneration
History of Chemistry, War, Atomic Bomb, Gas
STEM Outreach
Synthetic Organic
Synthetic Inorganic
Accomplishments (5)
ACS Outreach Volunteer of the Year - DFW Section (professional)
2022
TCU Clark Society Endowed Faculty Award (professional)
2021-22
American Chemical Society, Women’s Chemist Committee Rising Star Award (professional)
2020
Tarleton Alumni Academic Forum Honoree for the College of Science and Technology (professional)
2020
U.S. Senator Phil Gramm Doctoral Fellowship Award (professional)
2007-01-01
Chemistry Biology Interface
Education (3)
UT Southwest Medical Center: Postdoctoral Research 2009
Texas A&M University: Ph.D., Chemistry 2007
Tarleton State University: B.S., Chemistry 2002
Affiliations (1)
- Director, The Green Research Group
Links (2)
Media Appearances (3)
Who Was The Real Oppenheimer?
Huffington Post online
2023-07-20
Still, while Oppenheimer unleashed the world’s deadliest weapon, it seems he was doing what he thought was necessary at the time. As Kayla Green, a chemistry professor at Texas Christian University in Fort Worth who recently taught a class called “How Chemists Win Wars,” put it: “Oppenheimer was human.”
Annual Campaign Supports Scholarships, Innovative Academics
TCU News online
2022-03-31
Last year, the Clark Society Board proudly announced the creation of the Clark Society Endowed Faculty Fund. As the inaugural recipient of this fund, Kayla Green, associate professor of chemistry and biochemistry, continues her research and creative activities as a teacher and a scholar.
The Neurobiology of Aging
TCU Magazine online
2015-09-23
Three professors in TCU’s College of Science and Engineering are using the tools of their respective academic disciplines to research the disease. Associate professor of biology Michael Chumley, assistant professor of chemistry Kayla Green and associate professor of psychology Gary Boehm formed the Neurobiology of Aging Collaborative to study the amyloid beta proteins associated with Alzheimer’s disease. They are researching how the proteins form and impair cognition as well as how that formation process might be interrupted.
Research Grants (7)
Mechanistic Insights and Therapeutic Potential of the Glutaredoxin (Grx) System in the Lens
National Institutes of Health $275,000
Period: 02/01/2023-01/31/2025
TCU eFROGS (Evaluating Female Resources and Opportunities for Growth in STEM)
National Science Foundation $300,001.26
[no period given]
Building Better Antioxidants: Virtual Screening, Synthesis, and Characterization of Multifunctional Small Molecules Combining Nrf2 Pathway Activation and Direct Antioxidant Activity
National Institutes of Health $379,063
Period: 02/01/2022-01/31/2025
Antioxidant Small Molecules Targeting Alzheimer’s Disease
Flatley Foundation through the TCU College of Science and Engineering $25,000
Period: 01/01/2022 – 06/30/2023
Stabilizing catalysts for HAT reactivity in pyridinophane metallopolymers
ACS-PRF $110,000
Period: 01/01/2022 – 08/31/2024
Building Better Molecules to Target Oxidative Stress
Robert A. Welch Foundation $240,000
Period: 06/01/2021 – 05/31/2025
Targeting oxidative stress in neurodegeneration using pyridol-derived small molecules
National Institutes of Health $378,914
Period: 06/01/2018-05/31/2021
Articles (5)
Nitrogen-doped graphene quantum dots: Optical properties modification and photovoltaic applications
Nano ResearchMd Tanvir Hasan, Roberto Gonzalez-Rodriguez, Conor Ryan, Kristof Pota, Kayla Green, Jeffery L Coffer, Anton V Naumov
2019 In this work, we utilize a bottom-up approach to synthesize nitrogen self-doped graphene quantum dots (NGQDs) from a single glucosamine precursor via an eco-friendly microwave-assisted hydrothermal method. Structural and optical properties of as-produced NGQDs are further modified using controlled ozone treatment. Ozone-treated NGQDs (Oz-NGQDs) are reduced in size to 5.5 nm with clear changes in the lattice structure and ID/IG Raman ratios due to the introduction/alteration of oxygen-containing functional groups detected by Fourier-transform infrared (FTIR) spectrometer and further verified by energy dispersive X-ray spectroscopy (EDX) showing increased atomic/weight percentage of oxygen atoms.
Crystallographic Characterization and Non‐Innocent Redox Activity of the Glycine Modified DOTA Scaffold and Its Impact on EuIII Electrochemistry
European journal of inorganic chemistry2018 EuDOTA‐glycine derivatives have been explored as alternatives to typical gadolinium‐containing complexes for MRI agents used in diagnostic imaging. Different imaging modalities can be accessed (T1 or PARACEST) dependent on the oxidation state of the europium ion. Throughout the past 30 years, there have been significant manipulations and additions made to the DOTA scaffold; yet, characterizations related to electrochemistry and structure determined through XRD analysis have not been fully analyzed. In this work, electrochemical analysis using cyclic voltammetry was carried out on EuDOTA derivatives, including the free ligand DOTAGly4 (4) and the complexes.
Increase of Direct C–C Coupling Reaction Yield by Identifying Structural and Electronic Properties of High-Spin Iron Tetra-azamacrocyclic Complexes
Inorganic chemistrySamantha M. BrewerKevin R. WilsonDonald G. JonesEric W. ReinheimerStephen J. ArchibaldTimothy J. PriorMegan A. AyalaAlexandria L. FosterTimothy J. Hubin*Kayla N. Green
2018 Macrocyclic ligands have been explored extensively as scaffolds for transition metal catalysts for oxygen and hydrogen atom transfer reactions. C–C reactions facilitated using earth abundant metals bound to macrocyclic ligands have not been well-understood but could be a green alternative to replacing the current expensive and toxic precious metal systems most commonly used for these processes.
Structural characterization of the aquaporin inhibitor 2-nicotinamido-1,3,4-thiadiazole
Acta crystallographica2015 Nicotinamides are a class of compounds with a wide variety of applications, from use as antimicrobial agents to inhibitors of biological processes. These compounds are also cofactors, which are necessary components of metabolic processes. Structural modification gives rise to the activities observed. Similarly, 1,3,4-thiadiazoles have been shown to possess antioxidant, antimicrobial, or anti-inflammatory biological activity. To take advantage of each of the inherent characteristics of the two aforementioned functional groups, 2-nicotinamido-1,3,4-thiadiazole, C 8 H 6 N 4 OS, was synthesized. Since defining chemical connectivity is paramount in understanding biological activity, in this report, the structural characterization of 2-nicotinamido-1,3,4-thiadiazole has been carried out using X-ray crystallographic methods. The NMR-derived assignments were made possible by utilizing one- (1D) and two-dimensional (2D) NMR techniques. In addition, UV–Visible and IR spectroscopies, and elemental analysis were used to fully characterize the product synthesized by the one-step reaction between nicotinoyl chloride hydrochloride and 2-amino-1,3,4-thiadiazole. Computational parameters related to blood–brain barrier permeability are also presented.
Synthetic Methodology for Asymmetric Ferrocene Derived Bio-conjugate Systems via Solid Phase Resin-based Methodology
Journal of Visualized Experiments2015 Early detection is a key to successful treatment of most diseases, and is particularly imperative for the diagnosis and treatment of many types of cancer. The most common techniques utilized are imaging modalities such as Magnetic Resonance Imaging (MRI), Positron Emission Topography (PET), and Computed Topography (CT) and are optimal for understanding the physical structure of the disease but can only be performed once every four to six weeks due to the use of imaging agents and overall cost. With this in mind, the development of "point of care" techniques, such as biosensors, which evaluate the stage of disease and/or efficacy of treatment in the clinician's office and do so in a timely manner, would revolutionize treatment protocols.1 As a means to exploring ferrocene based biosensors for the detection of biologically relevant molecules2, methods were developed to produce ferrocene-biotin bio-conjugates described herein. This report will focus on a biotin-ferrocene-cysteine system that can be immobilized on a gold surface.
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