Linda Mansfield
University Distinguished Professor, Albert C and Lois E. Dehn Endowed Chair in Veterinary Medicine Michigan State University
- East Lansing MI
Linda Mansfield investigates enteric pathogens that cause gastrointestinal disease and explores new therapies for Inflammatory Bowel Disease
Biography
Industry Expertise
Areas of Expertise
Accomplishments
University Distinguished Professor
2015-06-21
Michigan State University
Education
University of Pennsylvania,
Ph.D.
Parasitology/Microbiology
1990
University of Pennsylvania
V.M.D.
Veterinary Medicine
1986
University of Delaware
M.S.
Virology
1980
University of Delaware
B.S.
Biology
1975
Affiliations
- American Academy of Microbiology, Fellow
News
DOD-funded research could lead to diagnostics, therapies for rare neurological disorder
MSU Today online
2020-11-23
Most of the time, food poisoning is just that — we eat something rotten or contaminated, we get sick, we get better and we move on. But in the case of Campylobacter jejuni, the world’s most common food poisoning-inducing pathogen, a rare neurological disorder called Guillain-Barré Syndrome can be provoked.
Mansfield, Collaborators Awarded DOD Grant to Study Guillain Barré Syndrome
MSU Today online
2020-01-10
University Distinguished Professor Dr. Linda Mansfield and four other scientists were awarded funding from the United States Department of Defense to examine the contribution of the human gut microbiota and carbohydrate-mediated immune response to the development and severity of Guillain Barré Syndrome (GBS).
“GBS is the world’s leading cause of acute neuromuscular paralysis and it occurs after food poisoning with the bacterium Campylobacter jejuni,” says Mansfield. According to a 2009 case-control study, Military personnel have an incidence of GBS that is more than double that seen in the general United States population.
Linda Mansfield - University Distinguished Professor
PBS tv
2015-11-24
Linda Mansfield, College of Veterinary Medicine, Large Animal Clinical Sciences, Microbiology and Molecular Genetics, named University Distinguished Professor in 2015. The title is conferred on selected MSU faculty members to recognize distinguished achievement in teaching, research and public service.
Journal Articles
Campylobacter jejuni induces autoimmune peripheral neuropathy via Sialoadhesin and Interleukin-4 axes
Gut MicrobesAnkit Malik, Jean M Brudvig, Barbie J Gadsden, Alexander D Ethridge, Linda S Mansfield
2022-04-20
Campylobacter jejuni is a leading cause of gastroenteritis that has been causally linked with development of the autoimmune peripheral neuropathy Guillain Barré Syndrome (GBS). Previously, we showed that C. jejuni isolates from human enteritis patients induced Type1/17-cytokine dependent colitis in interleukin-10 (IL-10)−/− mice, while isolates from GBS patients colonized these mice without colitis but instead induced autoantibodies that cross-reacted with the sialylated oligosaccharide motifs on the LOS of GBS-associated C. jejuni and the peripheral nerve gangliosides.
We show here that infection of IL-10−/− mice with the GBS but not the colitis isolate led to sciatic nerve inflammation and abnormal gait and hind limb movements, with character and timing consistent with this syndrome in humans.
Conjugative RP4 Plasmid-Mediated Transfer of Antibiotic Resistance Genes to Commensal and Multidrug-Resistant Enteric Bacteria In Vitro
MicroorganismsAzam A. Sher, Mia E. VanAllen, Husnain Ahmed, Charles Whitehead-Tillery, Sonia Rafique, Julia A. Bell, Lixin Zhang, Linda S. Mansfield
2023-01-12
Many antibiotic-resistant bacteria carry resistance genes on conjugative plasmids that are transferable to commensals and pathogens. We determined the ability of multiple enteric bacteria to acquire and retransfer a broad-host-range plasmid RP4.
