Lisa Holle, Pharm.D., BCOP, FHOPA

University of Wisconsin-Madison

PharmD

Pharmacy

1995

University of Wisconsin-Madison

BA

Pharmacy

1993

Improving P1 Student Pharmacist Readiness for Introductory Community Pharmacy Practice Experience

UConn Center for Excellence in Education and Learning

Principal Investigators: Fitzgerald J, Holle LM.

Can Spinners Improve Understanding of Adverse Events in Patients with Cancer?

International Society of Oncology Pharmacy Practitioners Research Grant

Principal Investigator: Holle LM; Co-Investigators: Eyler, R, Dixon J, Fraenkel, L, White C.

Daniel E. Buffington Guest Professorship

Daniel E. Buffington Guest Professorship

Holle LH, Buckley T, Chamberlin K, Fitzgerald J, Smith MA, White CM

Implementation of a virtual dispensing simulator to support US pharmacy education.

Ferrone M., Kebodeaux C., Fitzgerald J., & Holle L.

2017-05-30

A key element for pharmacy practice defined by the Accreditation Council for Pharmacy Education (ACPE) is medication use systems management. A web-based community pharmacy simulation originally created for Australian pharmacy students was adapted for pharmacy students in the United States (US). The objective of this study was to collaboratively adapt an existing international simulation program for utility in the US and measure student perceptions of a web-based community pharmacy simulation program in three US schools of pharmacy.

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Safe Administration of Intracerebral Spinal Fluid Chemotherapy: Time for Guidelines.

Clement JM., & Holle L.

2017-11-13

Intracerebral spinal fluid chemotherapy (ICC), administered by injection through lumbar puncture (intrathecal [IT]) or intraventricular Ommaya reservoir, is a therapy mainstay for prevention and/or treatment of leptomeningeal metastases. Administration techniques (eg, appropriate position, lack of trauma) play a role in optimal drug distribution after ICC.1-6 The antineoplastic drugs used in ICC have narrow therapeutic indices and high likelihood of systemic toxicity if improperly prepared or administered.7 Consequently, ICC administration is a complex procedure that may influence treatment decisions and outcomes, and has the potential for errors, some possibly fatal.

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Subcutaneous metastasis from recurrent basaloid squamous cell carcinoma of the esophagus.

Puri S., Holle L., Forouhar FA., & Clement JM.

2017-01-01

Background Esophageal cancer is the 11th most common cause of cancer mortality in the United States. It is aggressive in nature and has an ability to spread rapidly through direct extension, lymphatic spread, or hematogenously. With an estimated incidence of 1%, cutaneous metastases from esophageal cancer are extremely rare. Case presentation In this case study and review, we describe a case of recurrent esophageal basaloid squamous cell carcinoma presenting as multiple, rapidly progressing and tender subcutaneous nodules. A 69-year-old male with history of basaloid squamous cell carcinoma of the esophagus treated with concurrent chemoradiation, presented to his oncologist with complaints of a large, painful nodule at the nape of his neck approximately two years after completing treatment. On further examination, he was noted to have multiple, well circumscribed, solid, tender nodules on his abdominal wall along with a painful nodule on the pulp of his index finger. Histopathology from all sites revealed skin infiltration by high-grade invasive basaloid subtype of squamous cell carcinoma, similar to patient's prior known and treated primary esophageal cancer. Further imaging work up showed extensive metastatic disease involving lung, liver, and brain. Conclusion Esophageal squamous cell carcinoma rarely metastasize to the skin. Subcutaneous nodules can be the first presentation of recurrent disease. The lesions are commonly confused with skin infections and treated inappropriately with antibiotics, leading to delay in diagnosis of recurrent disease. Early biopsy of suspicious lesions should be performed, especially in patients with history of cancer, such that prompt diagnosis and treatment can occur to maximize patient outcomes.

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