Matey Kaltchev, Ph.D.
Professor, Department Chair Milwaukee School of Engineering
- Milwaukee WI
Dr. Matey Kaltchev's areas of expertise include Physical Chemistry, Surface Science, Nanoengineering
Milwaukee School of Engineering
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Education, Licensure and Certification
Ph.D.
Physical Chemistry
University of Wisconsin-Milwaukee
1999
M.S.
Engineering Physics
Sofia University
1983
Biography
Areas of Expertise
Accomplishments
Invited as a Reviewer of Papers Submitted to the 2004 Hawaii International Conference on Science
Renaissance Ilikai Waikiki Hotel, Honolulu, Hawaii
Department of Chemistry Annual Peer Award
University of Wisconsin - Milwaukee
Affiliations
- American Chemical Society (ACS)
- American Society of Chemical Engineers (AIChE)
- Society for Biological Engineering (SBE)
- American Society of Engineering Education (ASEE)
Social
Research Grants
National Science Foundation Grant
Engineering Research center for Compact and Efficient Fluid Power
Lead Investigator in Thrust 1.
National Science Foundation Grant 0521612
Major Research Instrumentation
Acquisition of a Scanning Probe Microscope for research in wear and failure analysis of metal composites.
Birnschein Foundation Grant
MSOE Development Office
Grant for the acquisition
of instrumentation to be used in the chemistry laboratory.
Bradley Foundation Grant
MSOE Development Office
Grant for remodeling the general chemistry laboratory classrooms.
Selected Publications
Development of a microscale red blood cell-shaped pectin-oligochitosan hydrogel system using an electrospray-vibration method: preparation and characterization
Journal of Applied Biomaterials & Functional MaterialsCrouse, J.Z., Mahuta, K.M., Mikulski, B.A., Harvestine, J.N., Guo, X., Lee, J.C., Kaltchev, M.G., Midelfort, K.S., Tritt, C.S., Chen, J., Zhang, W.
2015
To develop and characterize a microscale pectin-oligochitosan hydrogel microcapsule system that could be applied in such biological fields as drug delivery, cell immobilization/encapsulation, and tissue engineering.
Novel pectin-based carriers for colonic drug delivery
Pharmaceutical Development and TechnologyZhang, W., Mahuta, K.M., Mikulski, B.A., Harvestine, J.N., Crouse, J.Z., Lee, J.C., Kaltchev, M.G., Tritt, C.S.
2016
Pectin-based hydrogel carriers have been studied and shown to have promising applications for drug delivery to the lower GI tract, especially to the colonic region. However, making sure these hydrogel carriers can pass through the upper GI tract and reach the targeted regions, after oral administration, still remains a challenge to overcome. A solution to this problem is to promote stronger cross-linking interactions within the pectin-based hydrogel network. The combined usage of a divalent cation (Ca2+) and the cationic biopolymer oligochitosan has shown to improve the stability of pectin-based hydrogel systems – suggesting that these two cross-linkers may be used to eventually help improve pectin-based hydrogel systems for colonic drug delivery methods.
Design of artificial red blood cells using polymeric hydrogel microcapsules: hydrogel stability improvement and polymer selection
The International Journal of Artificial OrgansZhang, W., Bissen, M.J., Savela, E.S., Clausen, J.N., Fredricks, S.J., Guo, X., Paquin, Z.R., Dohn, R.P., Pavelich, I.J., Polovchak, A.L., Wedemeyer, M.J.
2016
To improve the stability of pectin-oligochitosan hydrogel microcapsules under physiological conditions.
Electrospinning pectin-based nanofibers: a parametric and cross-linker study
Applied NanoscienceMcCune, D., Guo, X., Shi, T., Stealey, S., Antrobus, R., Kaltchev, M., Chen, J., Kumpaty, S., Hua, X., Ren, W., Zhang, W.
2018
Pectin, a natural biopolymer mainly derived from citrus fruits and apple peels, shows excellent biodegradable and biocompatible properties. This study investigated the electrospinning of pectin-based nanofibers. The parameters, pectin:PEO (polyethylene oxide) ratio, surfactant concentration, voltage, and flow rate, were studied to optimize the electrospinning process for generating the pectin-based nanofibers. Oligochitosan, as a novel and nonionic cross-liker of pectin, was also researched. Nanofibers were characterized by using AFM, SEM, and FTIR spectroscopy. The results showed that oligochitosan was preferred over Ca2+ because it cross-linked pectin molecules without negatively affecting the nanofiber morphology. Moreover, oligochitosan treatment produced a positive surface charge of nanofibers, determined by zeta potential measurement, which is desired for tissue engineering applications.
Stability improvement and characterization of bioprinted pectin-based scaffold
Journal of Applied Biomaterials & Functional MaterialsStealey, S., Guo, X., Ren, L., Bryant, E., Kaltchev, M., Chen, J., Kumpaty, S., Hua, X., Zhang, W.
2019
Bioprinting is an alternative method for constructing tissues/organs for transplantation. This study investigated the cross-linker influence and post-printing modification using oligochitosan and chitosan for stability improvement.
