Matt Hitchings' research focuses on evaluating the effectiveness of interventions against infectious disease, including COVID-19, influenza and dengue virus. His areas of interest include clinical trials design and analysis, emerging infectious disease, infectious disease and vaccination.
Areas of Expertise (3)
Infectious Disease Epidemiology
Effectiveness of CoronaVac, ChAdOx1 nCoV-19, BNT162b2, and Ad26.COV2.S among individuals with previous SARS-CoV-2 infection in Brazil: a test-negative, case-control study.The Lancet Infectious Diseases
Thiago Cerqueira-Silva, et. al
COVID-19 vaccines have proven highly effective among individuals without a previous SARS-CoV-2 infection, but their effectiveness in preventing symptomatic infection and severe outcomes among individuals with previous infection is less clear. We aimed to estimate the effectiveness of four COVID-19 vaccines against symptomatic infection, hospitalization and death for individuals with laboratory-confirmed previous SARS-CoV-2 infection.
EVITA Dengue: a cluster-randomized controlled trial to EValuate the efficacy of Wolbachia-InfecTed Aedes aegypti mosquitoes in reducing the incidence of Arboviral infection in Brazil.Trials
Matthew H. Collins, et. al
Arboviruses transmitted by Aedes aegypti including dengue, Zika and chikungunya are a major global health problem, with over 2.5 billion at risk for dengue alone. There are no licensed antivirals for these infections, and safe and effective vaccines are not yet widely available. Thus, prevention of arbovirus transmission by vector modification is a novel approach being pursued by multiple researchers.
Effectiveness of a monthly schedule of follow-up for the treatment of uncomplicated severe acute malnutrition in Sokoto, Nigeria: A cluster randomized crossover trialPLOS Medicine
Matt D. T. Hitchings, et. al
Community-based management of severe acute malnutrition (SAM) involves weekly or biweekly outpatient clinic visits for clinical surveillance and distribution of therapeutic foods. Distance to outpatient clinics and high opportunity costs for caregivers can represent major barriers to access. Reducing the frequency of outpatient visits while providing training to caregivers to recognize clinical danger signs at home between outpatient visits may increase acceptability, coverage and public health impact of SAM treatment.
Structural factors contributing to SARS-CoV-2 infection risk in the urban slum setting.MedRxiv : The Preprint Server for Health Sciences.
Mariam O. Fofana, et. al
The structural environment of urban slums, including physical, demographic and socioeconomic attributes, renders inhabitants more vulnerable to SARS-CoV-2 infection. Yet, little is known about the specific determinants that contribute to high transmission within these communities. We performed a serosurvey of an established cohort of 2,035 urban slum residents from the city of Salvador, Brazil between November 2020 and February 2021, following the first COVID-19 pandemic wave in the country.