Matthew Gentry is a prominent brain metabolism scientist who has made seminal discoveries regarding brain glycogen and glucose metabolism and how perturbations in these pathways impact neuro-centric diseases. Matthew has nearly 20 years of experience working on glycogen storage diseases and is director of the NIH-funded Lafora Epilepsy Cure Initiative. He is a professor and chair of the Department of Biochemistry and Molecular Biology in the College of Medicine.
Areas of Expertise (5)
Glycogen Storage Diseases
Media Appearances (5)
University of Kentucky researchers discover fundamental roles of glucosamine in brain
University of Kentucky News online
Using novel imaging methods for studying brain metabolism, University of Kentucky researchers have identified the reservoir for a necessary sugar in the brain. Glycogen serves as a storage depot for the sugar glucose.
An unprecedented impact: a series of fact sheets on COVID-19 and biomedical research
United for Medical Research online
We must maintain and strengthen our nation’s investment in medical research through the National Institutes of Health.
The coronavirus pandemic claims another victim: Medical research for deadly rare diseases
The Washington Post online
Anissa Merriam was a vibrant teenager, a talented artist who loved anime and excelled in difficult classes. But at 14, she started dropping her pencil and her hairbrush, and struggled with her studies.
NINDS announces 20 new recipients of Research Program Award
National Institute of Neurological Disorders and Stroke online
The National Institute of Neurological Disorders and Stroke, part of the National Institutes of Health, announced the latest recipients of the R35 Research Program Award (RPA).
Preclinical study of therapeutic strategy for lafora disease shows promise
When it comes to medical breakthroughs, sometimes one can never know when basic and rudimentary research might bear fruit. That’s certainly the case with the person you’re about to meet and the specific type of disease he’s been working to cure.
In situ mass spectrometry imaging reveals heterogeneous glycogen stores in human normal and cancerous tissuesEMBO Molecular Medicine
Lyndsay E A Young, et. al
Glycogen dysregulation is a hallmark of aging, and aberrant glycogen drives metabolic reprogramming and pathogenesis in multiple diseases. However, glycogen heterogeneity in healthy and diseased tissues remains largely unknown. Herein, we describe a method to define spatial glycogen architecture in mouse and human tissues using matrix-assisted laser desorption/ionization mass spectrometry imaging.
High-dimensionality reduction clustering of complex carbohydrates to study lung cancer metabolic heterogeneityHigh-dimensionality reduction clustering of complex carbohydrates to study lung cancer metabolic heterogeneity.
Lindsey R.Conroy, et. al
The tumor microenvironment contains a heterogeneous population of stromal and cancer cells that engage in metabolic crosstalk to ultimately promote tumor growth and contribute to progression. Due to heterogeneity within solid tumors, pooled mass spectrometry workflows are less sensitive at delineating unique metabolic perturbations between stromal and immune cell populations. Two critical, but understudied, facets of glucose metabolism are anabolic pathways for glycogen and N-linked glycan biosynthesis.
Activation of Drp1 promotes fatty acids-induced metabolic reprograming to potentiate Wnt signaling in colon cancerCell Death & Differentiation
Xiaopeng Xiong, et. al
Cancer cells are known for their ability to adapt variable metabolic programs depending on the availability of specific nutrients. Our previous studies have shown that uptake of fatty acids alters cellular metabolic pathways in colon cancer cells to favor fatty acid oxidation. Here, we show that fatty acids activate Drp1 to promote metabolic plasticity in cancer cells. Uptake of fatty acids (FAs) induces mitochondrial fragmentation by promoting ERK-dependent phosphorylation of Drp1 at the S616 site.
Analysis of circulating metabolites to differentiate Parkinson’s disease and essential tremorNeuroscience Letters
Elena A. Ostrakhovitch, et. al
Parkinson’s disease (PD) and essential tremor (ET) are two common adult-onset tremor disorders in which prevalence increases with age. PD is a neurodegenerative condition with progressive disability. In ET, neurodegeneration is not an established etiology. We sought to determine whether an underlying metabolic pattern may differentiate ET from PD.