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M. Cristina Polidori - International Federation on Ageing. Köln, , DE

M. Cristina Polidori M. Cristina Polidori

Professor of Ageing Medicine and Geriatrics | University Hospital of Cologne

Köln, GERMANY

Dr. Polidori is the head of the Ageing Clinical Research Unit of the Dpt II of Internal Medicine at the University Hospital of Cologne

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Biography

M. Cristina Polidori is MD, Geriatrician and Gerontologist. She is the head of the Ageing Clinical Research Unit at the Dpt. II of Internal Medicine and Center for Molecular Medicine of the University Hospital of Cologne, Germany. Dr. Polidori's fields of expertise are 1) comprehensive geriatric assessment (CGA)-based prognosis and geriatric resource evaluation for personalized multidomain interventions in advanced age; 2) nutritional cognitive neuroscience; 3) translational challenges of bridging the gap between Geroscience and Geriatrics for healthy aging and 4) role of geriatric education for medical students and HealthCare professionals to improve the management of older adults. M. C. Polidori is Professor of Geriatrics, Professor of Physiological Chemistry and PI-Associate member of the Cluster of Excellence CECAD of the University of Cologne. She is author of over 130 peer-reviewed publications and co-editor of the first EuGMS textbook of Geriatrics Learning Geriatric Medicine. Dr. Polidori received numerous prestigious awards in the field of aging Research, is Honorary Fellow of the Royal College of Physicians and President of the German Association for Cognitive Training e.V.

Areas of Expertise (5)

Nutritional Cognitive Neuroscience

Healthy Ageing

Geriatrics and Gerontology

Ageing Medicine

Comprehensive Geriatric Assessment

Accomplishments (5)

Catherine Pasquier Award for Free Radical Research (professional)

2007

Schiffbauer Award for Geriatrics (professional)

2012

Award for Interdisciplinary Research on Ageing (professional)

2017

Umbria in Rosa Award for Research (professional)

2018

Award of the Wilhelm-Woort Foundation for Research on Aging (professional)

2019

Education (3)

Medical Faculty of the University of Perugia, Italy: MD Degree 1993

Harvard Medical School and Whitaker Cardiovascular Institute: Research Fellow, Neurology 1997

University of Perugia, Italy: Master, Philosophy 2005

Affiliations (3)

  • Cluster of Excellence CECAD of the University of Cologne : PI-Associate member
  • Royal College of Physicians : Honorary Fellow
  • German Association for Cognitive Training e.V. : President

Research Grants (8)

Young Investigator Grant

National Council of Research Italy 

1993-1995

Italian Centenarians Study

EU Marie-Curie Fellowship

EU Marie-Curie 

In the field Quality of life and Management of Living resources

Düsseldorf Research Commission

Heinrich-Heine University Düsseldorf Research Commission 

2004-2006

Robert-Bosch Foundation for Geriatrics

Robert-Bosch Foundation 

2008-2012

EU Executive Agency

EU Executive Agency for Health and Consumers 

In the frame of Active and Healthy Ageing 2nd-Health Programme, MPI_Age Study 2013-2017

EU JPND NeuroExercise Study

EU JPND NeuroExercise 

2015-2018

EuroSAF Study

EuroSAF 

2018-2020

Ageing Research

Wilhelm-Woort Foundation 

2019-2021

Featured Articles (5)

Using the Multidimensional Prognostic Index (MPI) to improve cost-effectiveness of interventions in multimorbid frail older persons: results and final recommendations from the MPI_AGE European Project Aging Clinical and Experimental Research

Alfonso J. Cruz-Jentoft, Julia Daragjati, Laura Fratiglioni, Stefania Maggi, Arduino A. Mangoni, Francesco Mattace-Raso, Marc Paccalin, Maria Cristina Polidori, Eva Topinkova, Luigi Ferrucci, Alberto Pilotto & on behalf of the MPI_AGE Investigators

2020-03-16

MPI_AGE is a European Union co-funded research project aimed to use the Multidimensional Prognostic Index (MPI), a validated Comprehensive Geriatric Assessment (CGA)-based prognostic tool, to develop predictive rules that guide clinical and management decisions in older people in different European countries. A series of international studies performed in different settings have shown that the MPI is useful to predict mortality and risk of hospitalization in community-dwelling older subjects at population level. Furthermore, studies performed in older people who underwent a CGA before admission to a nursing home or receiving homecare services showed that the MPI successfully identified groups of persons who could benefit, in terms of reduced mortality, of specific therapies such as statins in diabetes mellitus and coronary artery disease, anticoagulants in atrial fibrillation and antidementia drugs in cognitive decline. A prospective trial carried out in nine hospitals in Europe and Australia demonstrated that the MPI was able to predict not only in-hospital and long-term mortality, but also institutionalization, re-hospitalization and receiving homecare services during the one-year follow-up after hospital discharge. The project also explored the association between MPI and mortality in hospitalized older patients in need of complex procedures such as transcatheter aortic valve implantation or enteral tube feeding. Evidence from these studies has prompted the MPI_AGE Investigators to formulate recommendations for healthcare providers, policy makers and the general population which may help to improve the cost-effectiveness of appropriate health care interventions for older patients.

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A multidimensional approach to frailty in older people Ageing Research Reviews

Alberto Pilotto, Carlo Custodero, Stefania Maggi, Maria Cristina Polidori, Nicola Veronese, Luigi Ferrucci

2020-07-01

Frailty is an important factor determining a higher risk of adverse health outcomes in older adults. Although scientific community in the last two decades put a lot of effort for its definition, to date no consensus was reached on its assessment. The mainstream thinking describes frailty as a loss of physical functions or as accumulation of multiple deficits. Recently, a novel conceptual model of frailty has emerged based on the loss of harmonic interaction between multiple domains (also referred as dimensions) including genetic, biological, functional, cognitive, psychological and socio-economic domain that ultimately lead to homeostatic instability. Therefore, the multidimensional aspects of frailty condition could be captured by the comprehensive geriatric assessment (CGA) and its derived Multidimensional Prognostic Index (MPI). This instrument has been applied in different clinical settings and in several cohorts of older adults with specific acute and chronic diseases, showing always excellent accuracy in stratifying population according the mortality risk and other negative health outcomes, i.e. hospitalization, institutionalization or admission to homecare services. This MPI “plasticity” provides a single numerical prognostic index which could be helpful in clinical decision making for the management of frail older adults.

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Strategies to prevent age-related cognitive decline Dtsch Med Wochenschr

Meyer AM, Podolski N, Pickert L, Polidori MC

2020-02-01

The increasing aging demographics never seen before is associated with the enormous challenge of dementia epidemics which urgently needs a paradigm shift in the approach to cognitive functions in health and disease. If on one hand the achievement or maintenance of a healthy lifestyle should be a medical priority, the early recognition of cognitive disturbances is mandatory. Cognitive impairment is not only associated with disability and lack of compliance and adherence, but also with dangerous geriatric syndromes such as instability, falls, and delirium.

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Inflammation, Lipid (Per)oxidation, and Redox Regulation Antioxidants & Redox Signaling

Irundika H.K. Dias, Ivana Milic, Christian Heiss, Opeyemi S. Ademowo, Maria Cristina Polidori, Andrew Devitt, and Helen R. Griffiths

2020-02-28

Significance: Inflammation increases during the aging process. It is linked to mitochondrial dysfunction and increased reactive oxygen species (ROS) production. Mitochondrial macromolecules are critical targets of oxidative damage; they contribute to respiratory uncoupling with increased ROS production, redox stress, and a cycle of senescence, cytokine production, and impaired oxidative phosphorylation. Targeting the formation or accumulation of oxidized biomolecules, particularly oxidized lipids, in immune cells and mitochondria could be beneficial for age-related inflammation and comorbidities.

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Older women are frailer, but less often die than men: a prospective study of older hospitalized people Maturitas

Veronese N, Siri G, Cella A, Daragjati J, Cruz-Jentoft AJ, Polidori MC, Mattace-Raso F, Paccalin M, Topinkova E, Greco A, Mangoni AA, Maggi S, Ferrucci L, Pilotto A; MPI AGE Investigators.

2019-10-01

The association between frailty, mortality and sex is complex, but a limited literature is available on this topic, particularly for older hospitalized patients. Therefore, the objective of our study was to prospectively evaluate sex differences in frailty, assessed by the Multidimensional Prognostic Index (MPI) and mortality, institutionalization, and re-hospitalization in an international cohort of older people admitted to hospital.

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