Meera Sitharam
Professor University of Florida
- Gainesville FL
Meera Sitharam's expertise is in discrete and computational geometry with research in algorithms, bioinformatics and machine learning.
Biography
Areas of Expertise
Articles
A new discrete-geometry approach for integrative docking of proteins using chemical crosslinks
PubMed CentralZhang, et al.
2024-10-29
We develop a new discrete geometry-based method, wall-EASAL, for integrative rigid docking of protein pairs given the structures of the constituent proteins and chemical crosslinks.
Characterizing graph-non edge pairs with single interval Cayley configuration spaces in 3-dimension
arXivSims & Sitharam
2024-09-21
For d≤3, we characterize pairs (G,f), where f is a nonedge of G, such that, for any squared edge-length map ℓ, there is a single interval of attained distance values between the endpoints of f over all d-realizations of (G,ℓ), answering a question posed a decade ago, which gave an equivalent characterization for d≤2 that does not generalize to d≥3.
Best of two worlds: Cartesian sampling and volume computation for distance-constrained configuration spaces using Cayley coordinates
arXivZhang & Sitharam
2024-08-29
In this article, we present our sampling-based volume computation method using distance-based Cayley coordinate, mitigating drawbacks: our method guarantees that the sampling procedure stays in lower-dimensional coordinate space (instead of higher-dimensional Cartesian space) throughout the whole process; and our mapping function, utilizing Cayley parameterization, can be applied in both directions with low computational cost.
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