Noelle Comolli, PhD

Professor of Chemical and Biological Engineering; Associate Dean for Faculty Affairs | College of Engineering | Villanova University

Villanova, PA, UNITED STATES

Noelle Comolli, PhD, researches the use of different polymers for either novel biomaterials or controlled release delivery vehicles

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Areas of Expertise (6)

Biomaterials

Chemical Engineering

Drug Delivery

Nanoparticles

Polymer Chemistry

Spinal Cord Research

Biography

Noelle Comolli, PhD, is an Associate Professor of Chemical and Biological Engineering and Director of the Polymeric Biomaterials Laboratory at Villanova College of Engineering. Her research has included nanoparticles for axonal guidance after spinal cord injury, thin film delivery of anti-inflammatory agents, development of novel microparticles for tumor targeting, and nanoparticles for inhaled drug delivery.

Education (2)

Drexel University: PhD

University of Delaware: BS

Links (1)

Polymeric Biomaterials Lab

Select Media Appearances (1)

Nanoparticle Platform Delivers Drugs Across Blood-Brain Barrier in Mice

Medscape (Reuters Health) print

2021-01-15

NEW YORK (Reuters Health) - A novel nanoparticle drug delivery system had a therapeutic effect in a mouse model of traumatic brain injury (TBI), regardless of whether the blood-brain barrier (BBB) was physically breached or intact, researchers say. ... Dr. Noelle Comolli, Chair of Chemical Engineering at Villanova University in Pennsylvania, commented by email, "These nanoparticle platforms are becoming increasingly common, and similar to the lipid nanoparticle coating used in the new mRNA vaccines for COVID. These show great promise, since the increased permeability can be used in so many applications, not just TBI." "The polymer (PLGA) and varying coatings are not new, and have been used in many applications already, which makes this even more promising," said Dr. Comolli, who was not involved in the study. "What is new is the very small size and study on the exact effect of surface coating and density of surface coating on crossing the BBB." "Because this is a similar design to many other nanoparticle designs that may NOT be intended to cross the BBB, we may want to be more cautious from now on about checking that our designs do not unintentionally cross the BBB," she added.

Select Academic Articles (7)

Synthesis and characterization of multi-targeted polymeric antibody-microparticle conjugates with controlled drug release

International Journal of Polymeric Materials and Polymeric Biomaterials

Lucia Fernandez, Shannon Oakes, John Cipullo, Cole Moros, Jenna Hofman & Noelle Comolli

2024

Chemotherapeutic loading via tailoring of drug-carrier interactions in poly (sialic acid) micelles

AIMS Bioengineering

Gerald Pawlish, Kyle Spivack, Adam Gabriel, Zuyi Huang, Noelle Comolli

2018

MATLAB-Based Teaching Modules in Biochemical Engineering

Chemical Engineering Education

Kilho Lee, Noelle K Comolli, William J Kelly, Zuyi Jacky Huang

2015

Polymeric Microparticles

Engineering Polymer Systems for Improved Drug Delivery

Noelle K Comolli, Colleen E Clark

2014

Teaching tip: results of a survey on MATLAB & MathCAD education in bio-chemical engineering