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Noelle Comolli, PhD - Villanova University. Villanova, PA, US

Noelle Comolli, PhD

Associate Professor of Chemical Engineering; Associate Dean for Faculty Affairs | College of Engineering | Villanova University


Noelle Comolli, PhD, researches the use of different polymers for either novel biomaterials or controlled release delivery vehicles





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Arkema plant fires from Harvey flooding (August 2017)



Areas of Expertise (6)


Polymer Chemistry


Chemical Engineering

Drug Delivery

Spinal Cord Research


Noelle Comolli, PhD, is Chair of the Department of Chemical Engineering and Director of the Biomaterials and Drug Delivery Laboratory at Villanova College of Engineering. Her research has included nanoparticles for axonal guidance after spinal cord injury, thin film delivery of anti-inflammatory agents, development of novel microparticles for tumor targeting, and nanoparticles for inhaled drug delivery.

Education (2)

Drexel University: PhD

University of Delaware: BS

Select Media Appearances (1)

Nanoparticle Platform Delivers Drugs Across Blood-Brain Barrier in Mice

Medscape (Reuters Health)  print


NEW YORK (Reuters Health) - A novel nanoparticle drug delivery system had a therapeutic effect in a mouse model of traumatic brain injury (TBI), regardless of whether the blood-brain barrier (BBB) was physically breached or intact, researchers say. ... Dr. Noelle Comolli, Chair of Chemical Engineering at Villanova University in Pennsylvania, commented by email, "These nanoparticle platforms are becoming increasingly common, and similar to the lipid nanoparticle coating used in the new mRNA vaccines for COVID. These show great promise, since the increased permeability can be used in so many applications, not just TBI." "The polymer (PLGA) and varying coatings are not new, and have been used in many applications already, which makes this even more promising," said Dr. Comolli, who was not involved in the study. "What is new is the very small size and study on the exact effect of surface coating and density of surface coating on crossing the BBB." "Because this is a similar design to many other nanoparticle designs that may NOT be intended to cross the BBB, we may want to be more cautious from now on about checking that our designs do not unintentionally cross the BBB," she added.

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Select Academic Articles (5)

MATLAB-based Teaching Modules in Biochemical Engineering

Chemical Engineering Education

Kilho Lee, Noelle K Comolli, William J Kelly, Zuyi Jacky Huang


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Polymeric Microparticles

Engineering Polymer Systems for Improved Drug Delivery

Noelle K Comolli, Colleen E Clark


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Teaching Tip: Results of a Survey on MATLAB & MathCAD Education in Bio-Chemical Engineering

Chemical Engineering Education

Kilho Lee, Noelle Comolli, Vito Punzi, William J Kelly, Zuyi Jacky Huang


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An Integrated Experimental and Modeling Approach to Propose Biotinylated PLGA Microparticles as Versatile Targeting Vehicles for Drug Delivery

Progress in Biomaterials

Olivia Donaldson, Zuyi Jacky Huang, Noelle Comolli


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Polyvinyl Alcohol–polyvinyl Pyrrolidone Thin Films Provide Local Short‐term Release of Anti‐inflammatory Agents Post Spinal Cord Injury

Journal of Biomedical Materials Research Part B: Applied Biomaterials

Noelle Comolli, Olivia Donaldson, Nathan Grantier, Victoria Zhukareva, Veronica J Tom


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