Paola Marignani PhD, MBA

Professor Dalhousie University, Faculty of Medicine

  • Halifax, Canada Area NS

Dr. Paola Marignani is a scientist dedicated to developing personalized precision medicine that will improve human health.

Contact

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Areas of Expertise

Breast Cancer Research
Lung cancer Research
Gene Editing
CRISPR-Cas9
Transgenic mouse models of cancer
Cancer Metabolism
Epigenetics
Signal Trasnduction
Signalling networks
Neurodegenerative Disorders Related to Ageing
Alzheimer's Disease Spectrum
tumor suppressors and oncogenes
DNA stability and damage

Education

Ivey School of Business

MBA

Executive MBA

2013

Ontario Cancer Institute

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Cancer

2002

Samuel Lunenfeld Research Institute- Mount Sinai Hospital

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Mass Spectrometry

2001

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Languages

  • English
  • Italian
  • French
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Media Appearances

House hold chemicals

Global News  tv

Dr. Marignani and colleagues report on how low-dose exposure to common chemicals may contribute to the development of cancers and other diseases.

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Low dose chronic exposure to chemical mixtures

CTV  tv

Dr. Marignani, a member of the Halifax Project reports on how low-dose chronic exposure to common chemicals may contribute to the development of diseases.

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New Drug combination halts HER2+ breast cancer in mice engineered to develop cancer

Radio Canada  radio

Dr. Paola Marignani and her team of scientists have discovered a new drug combination that halts HER2+ breast cancer from developing in mice re-engineered to develop breast cancer. The new drugs; AZD8055 and 2-DG when administered alone, significantly inhibited tumour growth, however when combined, tumour growth was halted and pro-survival pathways that contribute to recurrence, were blocked.

Dr. Marignani is the first to combine treatments that attack two different molecular mechanisms; mTOR and glycolyisis.

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