Darragh Devine investigates the neurobiological basis of pathological behaviors that are co-morbid in autism and other neurodevelopmental disorders, including self-injury, sensory processing disorder and elevated anxiety. He is a professor of behavioral and cognitive neuroscience in the Department of Psychology and Neuroscience in the College of Liberal Arts and Sciences.
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Health and Wellness
Areas of Expertise (6)
Neurobiology of Self Injury
Neuroscience and the Brain
The Pemoline Model of Self-Injurious Behavior: An UpdatePsychiatric Disorders
Neurodevelopmental disorders typically comprise a complex constellation of behavioral symptoms and neurochemical abnormalities. However, many of the symptoms are inconsistently expressed within any one particular patient group or overlap between patient groups. In other words, there is usually heterogeneity of symptoms between diagnostic groups, and there is often partial homogeneity of symptoms across these groups.
Animal Models of Self-Injurious Behavior: An UpdatePsychiatric Disorders
Although self-injurious behavior is a common comorbid behavior problem among individuals with neurodevelopmental disorders, little is known about its etiology and underlying neurobiology. Interestingly, it shows up in various forms across patient groups with distinct genetic errors and diagnostic categories. This suggests that there may be shared neuropathology that confers vulnerability in these disparate groups.
Non-Suicidal Self-Injury: Neurobiological Findings From Animal ModelsBiological Psychiatry
Neuropsychiatric disorders are broadly defined and categorized according to clusters of behavioural symptoms. However, symptom expression can be heterogeneous within diagnostic categories and homogeneous across diagnostic categories. Accordingly, many recent investigations have focused upon identification and treatment of specific behavioural phenotypes. Non-suicidal self-injury (NSSI) is a phenotype that is highly prevalent in neuropsychiatric disorders, including Borderline Personality Disorder.
The role of neurotensin in vulnerability for self-injurious behaviour: studies in a rodent modelJournal of Intellectual Disability Research
A.M. Muehlmann, et al.
Self-injurious behaviour is a debilitating characteristic that is commonly expressed in people with autism and other neurodevelopmental disorders, but the neurobiological basis of this maladaptive behaviour is not understood. Abnormal dopaminergic and glutamatergic neurotransmission has been implicated, especially in relation to basal ganglia and mesocorticolimbic circuits.