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Rachael Seidler - University of Florida. Gainesville, FL, US

Rachael Seidler

Professor | University of Florida

Gainesville, FL, UNITED STATES

Rachael Seidler researches the neural control of movement in health and disease, with a specific focus on motor learning.


Rachael Seidler's research focuses on the neural control of movement in health and disease, with a specific focus on motor learning. She uses a range of neuroimaging and neuromodulation techniques coupled with precise measures of movement and cognitive function to determine the neurocognitive underpinnings of motor control. Rachael has expertise working with a variety of populations including healthy young and older adults, patients with Parkinson’s disease, and NASA astronauts in both basic science and intervention experiments. Her work has been supported by the NIH, the NSF, NASA, the National Space Biomedical Research Institute and a variety of private foundations. Active work in her lab includes investigation of human brain plasticity with spaceflight and experiments investigating which cognitive processes support skill acquisition and how they map onto underlying neural pathways.

Areas of Expertise (6)



Cognitive Ageing

Neuroscience and the Brain


Spaceflight Human Research

Media Appearances (5)

NASA Selects Proposals to Study Astronaut Health and Performance for Moon and Mars Missions

NASA  online


NASA's Human Research Program will fund seven proposals to help protect astronaut health and performance during future long-duration missions beyond low-Earth orbit. The selected proposals will investigate biological, physiological, and behavioral adaptations to spaceflight. The seven selected projects will contribute to NASA’s long-term plans, which include crewed missions to the Moon and Mars.

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Brains of Astronauts Show Deterioration Similar to Aging

Psychology Today  online


“The white matter changes were primarily in regions that control movement and process sensory inputs,” said Rachael Seidler, a professor of applied physiology and kinesiology at the University of Florida, and a coauthor of the study. When the human body is weightless in Earth orbit, the usual cues of gravity are missing, which could alter the typical inputs from senses. For example, the vestibular system provides people with a sense of balance and an awareness of how they are oriented in space. “A portion of the vestibular system also depends upon gravity for its signaling, so these inputs are also altered,” Seidler told Psychology Today.

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Spaceflight changes your brain pathways

UF News  online


The deterioration was the same type you’d expect to see with aging, but happened over a much shorter period of time. The findings could help explain why some astronauts have balance and coordination problems after returning to Earth, said Rachael Seidler, a professor with UF’s College of Health and Human Performance.

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Astronauts’ brains change shape during spaceflight

University of Michigan News  online


MRIs before and after space missions reveal that astronauts’ brains compress and expand during spaceflight, according to a University of Michigan study. The findings could have applications for treating other health conditions that affect brain function, says principal investigator Rachael Seidler, U-M professor of kinesiology and psychology.

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Brain connections break down as we age, study suggests

ScienceDaily  online


This slower reactivity is associated with an age-related breakdown in the corpus callosum, a part of the brain that acts as a dam during one-sided motor activities to prevent unwanted connectivity, or cross-talk, between the two halves of the brain, said Rachael Seidler, associate professor in the University of Michigan School of Kinesiology and Department of Psychology, and lead study author.

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Articles (5)

Brain activity during walking in older adults: Implications for compensatory versus dysfunctional accounts

Neurobiology of Aging

Tyler Fettrow, et al.


A prominent trend in the functional brain imaging literature is that older adults exhibit increased brain activity compared to young adults to perform a given task. This phenomenon has been extensively studied for cognitive tasks, with the field converging on interpretations described in two alternative accounts. One account interprets over-activation in older adults as reflecting neural dysfunction, whereas another interprets it as neural compensation.

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Visuomotor Adaptation Brain Changes During a Spaceflight Analog With Elevated Carbon Dioxide (CO2): A Pilot Study

Frontiers in Neural Circuits

Ana Paula Salazar, et al.


Astronauts on board the International Space Station (ISS) must adapt to several environmental challenges including microgravity, elevated carbon dioxide (CO2), and isolation while performing highly controlled movements with complex equipment. Head down tilt bed rest (HDBR) is an analog used to study spaceflight factors including body unloading and headward fluid shifts.

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GABA levels in ventral visual cortex decline with age and are associated with neural distinctiveness

Neurobiology of Aging

Jordan Chamberlain, et al.


Age-related neural dedifferentiation—a decline in the distinctiveness of neural representations in the aging brain—has been associated with age-related declines in cognitive abilities. But why does neural distinctiveness decline with age? Based on prior work in nonhuman primates and more recent work in humans, we hypothesized that the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) declines with age and is associated with neural dedifferentiation in older adults.

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Altered cerebral perfusion in response to chronic mild hypercapnia and head-down tilt Bed rest as an analog for Spaceflight

Functional Neuroradiology

Donna R. Roberts, et al.


Following prolonged stays on the International Space Station (ISS), some astronauts exhibit visual acuity changes, ophthalmological findings, and mildly elevated intracranial pressures as part of a novel process called spaceflight-associated neuro-ocular syndrome (SANS).

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The effects of a spaceflight analog with elevated CO2 on sensorimotor adaptation

Journal of Neurophysiology

Lauren A. Banker, et al.


Aboard the International Space Station, astronauts must adapt to altered vestibular and somatosensory inputs due to microgravity. Sensorimotor adaptation on Earth is often studied with a task that introduces visuomotor conflict. Retention of the adaptation process, known as savings, can be measured when subjects are exposed to the same adaptive task multiple times. It is unclear how adaptation demands found on the ISS might interfere with the ability to adapt to other sensory conflict at the same time.

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This is your brain in space with Rachael Seidler Rachael Seidler - 2016 HLKN Distinguished Lecture Series Prof. Rachael Seidler on satisfying curiosities Rachael Seidler Brain Research Documentary SMI 2018 Grand Guard 2020 webinar - Neuroscience and Aging Gracefully