Seidler's research focuses on the neural control of movement in health and disease, with a specific focus on motor learning. She uses a range of neuroimaging and neuromodulation techniques coupled with precise measures of movement and cognitive function to determine the neurocognitive underpinnings of motor control. Seidler has expertise working with a variety of populations including healthy young and older adults, patients with Parkinson’s disease, and NASA astronauts in both basic science and intervention experiments. Her work has been supported by the NIH, the NSF, NASA, the National Space Biomedical Research Institute (NSBRI), and a variety of private foundations. Active work in her lab includes investigation of human brain plasticity with spaceflight and experiments investigating which cognitive processes support skill acquisition and how they map onto underlying neural pathways.
Industry Expertise (2)
Health and Wellness
Areas of Expertise (5)
Spaceflight Human Research
Neuroscience and the Brain
Media Appearances (5)
NASA Selects Proposals to Study Astronaut Health and Performance for Moon and Mars Missions
NASA's Human Research Program will fund seven proposals to help protect astronaut health and performance during future long-duration missions beyond low-Earth orbit. The selected proposals will investigate biological, physiological, and behavioral adaptations to spaceflight. The seven selected projects will contribute to NASA’s long-term plans, which include crewed missions to the Moon and Mars.
Brains of Astronauts Show Deterioration Similar to Aging
Psychology Today online
“The white matter changes were primarily in regions that control movement and process sensory inputs,” said Rachael Seidler, a professor of applied physiology and kinesiology at the University of Florida, and a coauthor of the study. When the human body is weightless in Earth orbit, the usual cues of gravity are missing, which could alter the typical inputs from senses. For example, the vestibular system provides people with a sense of balance and an awareness of how they are oriented in space. “A portion of the vestibular system also depends upon gravity for its signaling, so these inputs are also altered,” Seidler told Psychology Today.
Spaceflight changes your brain pathways
UF News online
The deterioration was the same type you’d expect to see with aging, but happened over a much shorter period of time. The findings could help explain why some astronauts have balance and coordination problems after returning to Earth, said Rachael Seidler, a professor with UF’s College of Health and Human Performance.
Astronauts’ brains change shape during spaceflight
University of Michigan News online
MRIs before and after space missions reveal that astronauts’ brains compress and expand during spaceflight, according to a University of Michigan study. The findings could have applications for treating other health conditions that affect brain function, says principal investigator Rachael Seidler, U-M professor of kinesiology and psychology.
Brain connections break down as we age, study suggests
This slower reactivity is associated with an age-related breakdown in the corpus callosum, a part of the brain that acts as a dam during one-sided motor activities to prevent unwanted connectivity, or cross-talk, between the two halves of the brain, said Rachael Seidler, associate professor in the University of Michigan School of Kinesiology and Department of Psychology, and lead study author.
Visuomotor Adaptation Brain Changes During a Spaceflight Analog With Elevated Carbon Dioxide (CO2): A Pilot StudyFrontiers in Neural Circuits
Astronauts on board the International Space Station (ISS) must adapt to several environmental challenges including microgravity, elevated carbon dioxide (CO2), and isolation while performing highly controlled movements with complex equipment. Head down tilt bed rest (HDBR) is an analog used to study spaceflight factors including body unloading and headward fluid shifts. We recently reported how HDBR with elevated CO2 (HDBR+CO2) affects visuomotor adaptation. Here we expand upon this work and examine the effects of HDBR+CO2 on brain activity during visuomotor adaptation.
Brain activity during walking in older adults: Implications for compensatory versus dysfunctional accountsNeurobiology of Aging
A prominent trend in the functional brain imaging literature is that older adults exhibit increased brain activity compared to young adults to perform a given task. This phenomenon has been extensively studied for cognitive tasks, with the field converging on interpretations described in two alternative accounts. One account interprets over-activation in older adults as reflecting neural dysfunction (increased brain activity – indicates poorer performance), whereas another interprets it as neural compensation (increased brain activity - supports better performance).
GABA levels in ventral visual cortex decline with age and are associated with neural distinctivenessNeurobiology of Aging
Age-related neural dedifferentiation—a decline in the distinctiveness of neural representations in the aging brain—has been associated with age-related declines in cognitive abilities. But why does neural distinctiveness decline with age? Based on prior work in nonhuman primates and more recent work in humans, we hypothesized that the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) declines with age and is associated with neural dedifferentiation in older adults.
Altered cerebral perfusion in response to chronic mild hypercapnia and head-down tilt Bed rest as an analog for SpaceflightFunctional Neuroradiology
Following prolonged stays on the International Space Station (ISS), some astronauts exhibit visual acuity changes, ophthalmological findings, and mildly elevated intracranial pressures as part of a novel process called spaceflight-associated neuro-ocular syndrome (SANS). To determine the pathophysiology of SANS, NASA conducted a multi-investigator study in which 11 healthy participants underwent head-down tilt bed rest, mimicking microgravity-induced cephalad fluid shifts, combined with elevated ambient CO2 levels similar to those on the ISS (HDT+CO2). As part of that study, we examined the effects of HDT+CO2 on cerebral perfusion.
The effects of a spaceflight analog with elevated CO2 on sensorimotor adaptationJournal of Neurophysiology
Aboard the International Space Station (ISS), astronauts must adapt to altered vestibular and somatosensory inputs due to microgravity. Sensorimotor adaptation on Earth is often studied with a task that introduces visuomotor conflict. Retention of the adaptation process, known as savings, can be measured when subjects are exposed to the same adaptive task multiple times. It is unclear how adaptation demands found on the ISS might interfere with the ability to adapt to other sensory conflict at the same time. In the present study, we investigated the impact of 30 days’ head-down tilt bed rest combined with elevated carbon dioxide (HDBR + CO2) as a spaceflight analog on sensorimotor adaptation.
- Frontiers in Human Neuroscience : Associate Editor
- Journal of Motor Behavior : Executive Editor
- ISRN Rehabilitation : Editorial Board
- Frontiers in Cognition : Review Editor