Robert Quinn

Assistant Professor of Biochemistry Michigan State University

  • East Lansing MI

Robert Quinn's current research is on how the human microbiome is a consortium of microorganisms living on and in our bodies.

Contact

Michigan State University

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Biography

As an assistant professor at Michigan State University I use multi-omics methods including metagenomics, metabolomics and classic microbiology approaches to understand the causes of dysbiosis in host-associated microbial communities. I have studied the microbiome of everything from salmon, to lobsters, to corals, to lungs to guts, to….whatever is next. I’m a huge sports fan and spend some of my spare time trying figure out how to apply advanced baseball statistics to microbiome research.

I was raised in Bancroft, Ontario, Canada in close proximity to Algonquin Park which sparked my early interest in biology through constant interaction with the outdoors.

I received my undergraduate and Master degrees in microbiology at the University of Guelph in Ontario, Canada. I then completed a PhD with Dr. Andrei Chistoserdov at the University of Louisiana at Lafayette studying the microbiome of Epizootic Shell Disease in the American Lobster. I completed my postdoctoral studies with Dr. Forest Rohwer at San Diego State University and Pieter Dorrestein at UC San Diego studying the cystic fibrosis lung microbiome, coral reefs and other complex microbial systems.

Areas of Expertise

Microbiome
Cystic Fibrosis
Bile Acid
Metabolomics
Microorganisms
Microbiology
Environmental and Evolutionary Biology

Education

University of Louisiana at Lafayette

PhD

Environmental and Evolutionary Biology

2012

University of Guelph

MSc

Microbiology

2008

University of Guelph

BSc

Microbiology

2005

News

Scientists can tell how some corals survive climate-related coral bleaching events

CBC  online

2021-02-12

Increasing ocean temperatures due to climate warming are putting the world's coral reefs at risk of bleaching, a devastating process by which where once vibrant and colorful corals become a ghostly, skeletal white. Now scientists in Hawaii and Michigan think they know why some corals are susceptible to bleaching and others are not. Canadian scientist Robert Quinn, an assistant professor of microbiology at Michigan State University, spoke with Quirks & Quarks host Bob McDonald about what might be driving that crucial difference in how corals respond to the heat. Back in 2015, an extreme heating event that led to the bleaching of corals around the world created an opportunity for Quinn and his colleagues to study why some corals — even of the same species — turn white and others don't.

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How well antibiotics work for cystic fibrosis patients may be affected by PH, oxygen

MSU Today  online

2018-10-15

People living with cystic fibrosis spend their lives battling chronic lung infections resistant to antibiotic therapy. A one-size-fits all approach to wiping out the bacterium may not be the best approach for all patients with the disease, according to a new study led by Pieter Dorrestein, a professor at the University of California San Diego, and Robert Quinn, a Michigan State University researcher who conducted the research at UC San Diego.

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Journal Articles

Neutrophilic proteolysis in the cystic fibrosis lung correlates with a pathogenic microbiome

Microbiome

Robert A. Quinn, Sandeep Adem, Robert H. Mills, William Comstock, Lindsay DeRight Goldasich, Gregory Humphrey, Alexander A. Aksenov, Alexei V. Melnik, Ricardo da Silva, Gail Ackermann, Nuno Bandeira, David J. Gonzalez, Doug Conrad, Anthony J. O’Donoghue, Rob Knight & Pieter C. Dorrestein

2019

Studies of the cystic fibrosis (CF) lung microbiome have consistently shown that lung function decline is associated with decreased microbial diversity due to the dominance of opportunistic pathogens. However, how this phenomenon is reflected in the metabolites and chemical environment of lung secretions remains poorly understood.

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Microbial Transformations of Organically Fermented Foods

Metabolites

Ruma Raghuvanshi, Allyssa G. Grayson, Isabella Schena, Onyebuchi Amanze, Kezia Suwintono and Robert A. Quinn

2019

Fermenting food is an ancient form of preservation ingrained many in human societies around the world. Westernized diets have moved away from such practices, but even in these cultures, fermented foods are seeing a resurgent interested due to their believed health benefits. Here, we analyze the microbiome and metabolome of organically fermented vegetables, using a salt brine, which is a common ‘at-home’ method of food fermentation. We found that the natural microbial fermentation had a strong effect on the food metabolites, where all four foods (beet, carrot, peppers and radishes) changed through time, with a peak in molecular diversity after 2–3 days and a decrease in diversity during the final stages of the 4-day process. The microbiome of all foods showed a stark transition from one that resembled a soil community to one dominated by Enterobacteriaceae, such as Erwinia spp., within a single day of fermentation and increasing amounts of Lactobacillales through the fermentation process. With particular attention to plant natural products, we observed significant transformations of polyphenols, triterpenoids and anthocyanins, but the degree of this metabolism depended on the food type. Beets, radishes and peppers saw an increase in the abundance of these compounds as the fermentation proceeded, but carrots saw a decrease through time. This study showed that organically fermenting vegetables markedly changed their chemistry and microbiology but resulted in high abundance of Enterobacteriaceae which are not normally considered as probiotics. The release of beneficial plant specialized metabolites was observed, but this depended on the fermented vegetable.

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Cystic Fibrosis Rapid Response: Translating Multi-omics Data into Clinically Relevant Information

mBio

Ana Georgina Cobián Güemes, Yan Wei Lim, Robert A. Quinn, Douglas J. Conrad, Sean Benler, Heather Maughan, Rob Edwards, Thomas Brettin, Vito Adrian Cantú, Daniel Cuevas, Rohaum Hamidi, Pieter Dorrestein, Forest Rohwer

2019

Pulmonary exacerbations are the leading cause of death in cystic fibrosis (CF) patients. To track microbial dynamics during acute exacerbations, a CF rapid response (CFRR) strategy was developed. The CFRR relies on viromics, metagenomics, metatranscriptomics, and metabolomics data to rapidly monitor active members of the viral and microbial community during acute CF exacerbations. To highlight CFRR, a case study of a CF patient is presented, in which an abrupt decline in lung function characterized a fatal exacerbation. The microbial community in the patient’s lungs was closely monitored through the multi-omics strategy, which led to the identification of pathogenic shigatoxigenic Escherichia coli (STEC) expressing Shiga toxin. This case study illustrates the potential for the CFRR to deconstruct complicated disease dynamics and provide clinicians with alternative treatments to improve the outcomes of pulmonary exacerbations and expand the life spans of individuals with CF.

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