Roy Curtiss is a professor in the College of Veterinary Medicine's Department of Infectious Diseases and Immunology. Roy has expertise in genetics, microbiology, biomedical sciences and vaccinology, and he has worked in microbial pathogenesis, genetic manipulation and vaccine development.
Areas of Expertise (9)
Design, Construction and Evaluation of Vaccines
Gene Flow and Evolution
Genetic Manipulation of Bacteria and Their Viruses
Protective immunity enhanced Salmonella vaccine vectors delivering Helicobacter pylori antigens reduce H. pylori stomach colonization in miceFrontiers in Immunology
Amir Ghasemi, et. al
Helicobacter pylori is a major cause of gastric mucosal inflammation, peptic ulcers and gastric cancer. Emerging antimicrobial-resistant H. pylori has hampered the effective eradication of frequent chronic infections. Moreover, a safe vaccine is highly demanded due to the absence of effective vaccines against H. pylori. In this study, we employed a new innovative Protective Immunity Enhanced Salmonella Vaccine (PIESV) vector strain to deliver and express multiple H. pylori antigen genes.
Remodeling Yersinia pseudotuberculosis to generate a highly immunogenic outer membrane vesicle vaccine against pneumonic plaguePNAS
Xiuran Wang, et. al
SignificanceYersinia pestis, the etiologic agent of plague, has been responsible for high mortality in several epidemics throughout human history. This plague bacillus has been used as a biological weapon during human history and is currently one of the deadliest biological threats. Currently, no licensed plague vaccines are available in the Western world.
A triple-sugar regulated Salmonella vaccine protects against Clostridium perfringens-induced necrotic enteritis in broiler chickensPoultry Science
Shifeng Wang, et. al
Gram-positive Clostridium perfringens type G, the causative agent of necrotic enteritis (NE), has gained more attention in the poultry industry due to governmental restrictions on the use of growth-promoting antibiotics in poultry feed. Our previous work has proved that regulated delayed lysis Salmonella vaccines delivering a plasmid encoding an operon fusion of the nontoxic C-terminal adhesive part of alpha toxin and a GST-NetB toxin fusion were able to elicit significant protective immunity in broilers against C. perfringens challenge.