Professor Liu studies virus-host interactions, in particular how RNA viruses enter host cells and cause pathogenesis in humans and animals. While in the past the Liu lab has been mainly focusing on retroviruses, including HIV, current efforts also include some new human emerging and re-emerging infectious diseases, such as Ebola and Zika. Rotation and research projects include a better understanding the molecular process by which RNA viruses enter host cells or fuse with them, as well as developing effective ways to deliver human gene therapy. The Liu lab also studies some interferon-stimulated genes (ISGs), including IFITM, Viperin and Tetherin, with an ultimate goal of developing effective therapeutic strategies. Another aspect of Liu lab research is viral oncology, with major efforts in elucidating how some viral oncogenes induce oncogenic transformation leading to cancer as well as discovering new tumor viruses that could be associated with human lung and other epithelial cancers.
Industry Expertise (2)
Areas of Expertise (7)
University of Washington: Ph.D.
Zhengzhou University: M.D.
Media Appearances (5)
Ohio State lures Zika researcher to campus
That’s where you often can find Dr. Shan-Lu Liu, a virologist the university lured from the University of Missouri to join Ohio State’s Center for Retrovirus Research, as part of its Discovery Themes initiative to look at societal needs in fresh, creative ways.
Certain IFITM proteins block and inhibit cell-to-cell transmission of HIV
Human cells express Interferon Induced Transmembranes (IFITM) proteins that possess antiviral characteristics. These proteins have been shown to inhibit a number of viruses including influenza A, West Nile, Dengue fever and Ebola. In his study, Shan-Lu Liu, an associate professor in the Department of Molecular Microbiology and Immunology in the School of Medicine and an investigator in the Bond Life Sciences Center at MU, targeted IFITM proteins and their antiviral function...
The only thing you need to read about Ebola today: An expert Q&A
decoding science online
News headlines seem to feverishly spread as if they were a pandemic of the brain. Ebola hemorrhagic fever has been the most talked about disease of the year, appearing in thousands of headlines across the world since May. Through the noise of misinformation and sensationalism, fundamental information about the pandemic becomes harder to distinguish. In an interview with Decoding Science on Tuesday, Shan-Lu Liu, MD, PhD, a Bond Life Sciences Center investigator who studies Ebola, weighed in on the latest news. Liu, also an associate professor in the MU School of Medicine’s Department of Molecular Microbiology and Immunology, and his lab are particularly interested in the early behaviors of the virus in transmission and how it can navigate around the host immune response.
Protein tethers HIV and Ebola to cells
“This is a surprising finding that provides new insights into our understanding of not only HIV infection, but also that of Ebola and other viruses,” says Shan-Lu Liu, associate professor of molecular microbiology and immunology at University of Missouri...
Researchers discover protein's ability to inhibit HIV release
A family of proteins that promotes virus entry into cells also has the ability to block the release of HIV and other viruses, University of Missouri researchers have found. "This is a surprising finding that provides new insights into our understanding of not only HIV infection, but also that of Ebola and other viruses," said Shan-Lu Liu, M.D., Ph.D., associate professor in the MU School of Medicine's Department of Molecular Microbiology and Immunology. The study was recently published in the Proceedings of the National Academy of Sciences. Liu, the corresponding author of the study, is also an investigator with the Christopher S. Bond Life Sciences Center at MU. Read more at: https://medicalxpress.com/news/2014-08-protein-ability-inhibit-hiv.html#jCp
Recent Research (1)
University of Missouri-Columbia
A family of proteins that promotes virus entry into cells also has the ability to block the release of HIV and other viruses, University of Missouri researchers have found. "This is a surprising finding that provides new insights into our understanding of not only HIV infection, but also that of Ebola and other viruses," said Shan-Lu Liu, M.D., Ph.D., associate professor in the MU School of Medicine's Department of Molecular Microbiology and Immunology.