hero image
Shannon Wallet - University of Florida. Gainesville, FL, US

Shannon Wallet

Professor/Chair | University of Florida

Gainesville, FL, UNITED STATES

Shannon Wallet focuses on mechanisms associated with altered innate immune functions which lead to dysregulated adaptive immunity.


Shannon Wallet's research interests are focused on mechanisms associated with altered innate immune functions, which lead to dysregulated adaptive immunity. Most recently, her research program has grown due to productive collaborations in pulmonary mucosal immunology. Wallet's laboratory focuses on the contribution of epithelial cell biology and signaling to innate and adaptive immune homeostasis and dysfunction. It studies the contribution of ‘epithelial cell innate immune (dys)function’ to five major disease conditions: SARS-CoV-2 infection, burn and inhalation injury, periodontal disease (autoinflammation), Type 1 diabetes (autoimmunity), and pancreatic cancer.

Areas of Expertise (5)

Burn and Inhalation Injury

Mechanisms Associated with Altered Immune Functions

Oral Biology

Periodontal diseases

Pulmonary Mucosal Immunology


Articles (3)

Involvement of extracellular vesicles in the progression, diagnosis, treatment, and prevention of whole-body ionizing radiation-induced immune dysfunction

Frontiers in Immunology

Roland F. Seim, et. al


Acute radiation syndrome (ARS) develops after exposure to high doses of ionizing radiation and features immune suppression and organ failure. Currently, there are no diagnostics to identify the occurrence or severity of exposure and there are limited treatments and preventative strategies to mitigate ARS. Extracellular vesicles (EVs) are mediators of intercellular communication that contribute to immune dysfunction across many diseases.

view more

Intra-articular delivery of AAV vectors encoding PD-L1 attenuates joint inflammation and tissue damage in a mouse model of rheumatoid arthritis

Frontiers in Immunology

Wenjun Li, et. al


Objective: Rheumatoid arthritis (RA) is the most common form of autoimmune inflammatory arthritis. Intra-articular gene delivery to block proinflammatory cytokines has been studied in pre-clinical models and human clinical trials. It has been demonstrated that the level of programmed death-ligand 1 (PD-L1) is associated with rheumatoid arthritis (RA). This study examined the therapeutic role of PD-L1 by intra-articular delivery via adeno-associated virus (AAV) vectors in the mouse collagen-induced arthritis (CIA) model.

view more

Extracellular Vesicles as Regulators of Immune Function in Traumatic Injuries and Sepsis


Roland F. Seim, et. al


Despite advancements in critical care and resuscitation, traumatic injuries are one of the leading causes of death around the world and can bring about long-term disabilities in survivors. One of the primary causes of death for trauma patients are secondary phase complications that can develop weeks or months after the initial insult.

view more





loading image