Shannon Wallet
Professor/Chair | University of Florida
Gainesville, FL, UNITED STATES
Shannon Wallet focuses on mechanisms associated with altered innate immune functions which lead to dysregulated adaptive immunity.
Biography
Shannon Wallet's research interests are focused on mechanisms associated with altered innate immune functions, which lead to dysregulated adaptive immunity. Most recently, her research program has grown due to productive collaborations in pulmonary mucosal immunology. Wallet's laboratory focuses on the contribution of epithelial cell biology and signaling to innate and adaptive immune homeostasis and dysfunction. It studies the contribution of ‘epithelial cell innate immune (dys)function’ to five major disease conditions: SARS-CoV-2 infection, burn and inhalation injury, periodontal disease (autoinflammation), Type 1 diabetes (autoimmunity), and pancreatic cancer.
Areas of Expertise (5)
Burn and Inhalation Injury
Mechanisms Associated with Altered Immune Functions
Oral Biology
Periodontal diseases
Pulmonary Mucosal Immunology
Articles (3)
Involvement of extracellular vesicles in the progression, diagnosis, treatment, and prevention of whole-body ionizing radiation-induced immune dysfunction
Frontiers in ImmunologyRoland F. Seim, et. al
2023-06-15
Acute radiation syndrome (ARS) develops after exposure to high doses of ionizing radiation and features immune suppression and organ failure. Currently, there are no diagnostics to identify the occurrence or severity of exposure and there are limited treatments and preventative strategies to mitigate ARS. Extracellular vesicles (EVs) are mediators of intercellular communication that contribute to immune dysfunction across many diseases.
Intra-articular delivery of AAV vectors encoding PD-L1 attenuates joint inflammation and tissue damage in a mouse model of rheumatoid arthritis
Frontiers in ImmunologyWenjun Li, et. al
2023-03-03
Objective: Rheumatoid arthritis (RA) is the most common form of autoimmune inflammatory arthritis. Intra-articular gene delivery to block proinflammatory cytokines has been studied in pre-clinical models and human clinical trials. It has been demonstrated that the level of programmed death-ligand 1 (PD-L1) is associated with rheumatoid arthritis (RA). This study examined the therapeutic role of PD-L1 by intra-articular delivery via adeno-associated virus (AAV) vectors in the mouse collagen-induced arthritis (CIA) model.
Extracellular Vesicles as Regulators of Immune Function in Traumatic Injuries and Sepsis
ShockRoland F. Seim, et. al
2023-02-01
Despite advancements in critical care and resuscitation, traumatic injuries are one of the leading causes of death around the world and can bring about long-term disabilities in survivors. One of the primary causes of death for trauma patients are secondary phase complications that can develop weeks or months after the initial insult.
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